Joseph Lister, 1827-1912.
Open accessAbstract
Modern surgery began one hundred years ago, when the first of Joseph Lister's articles, entitled "A New Method of Treating Compound Fractures," appeared in the Lancet of 16 March 1867.The first published account of the application of the new system to operation wounds appeared in an article entitled " The Antiseptic Principle in the Practice of Surgery " in the British Medical 7ournal of 10 August that same year.These contrihutions opened a campaign that was destined to revolu- tionize surgery.Joseph Lister's education and upbringing prepared him for a life of scientific research.Born on 5 April 1827 at Upton, then near but now in London, he was the son of Joseph Jackson Lister, a prosperous city merchant whose spare time was devoted to study and research, especially optical research, in which he distinguished himself by discovering the best method of correct- ing chromatic aberration; for this and other work he was elected a Fellow of the Royal Society of London.The family were devout members of the Society of Friends, and Joseph was brought up to regard useful work almost as a sacred duty.At two private schools he had a good grounding in the classics, modern languages, mathematics, and natural history.Even as a schoolboy he performed some dissections, and at an early age he expressed a wish to become a surgeon.Owing to the religious tests he was not able to go to either Oxford or Cambridge University, but he was trained at Uni- versity College, London, and took his B.A. at London University in 1847.He then had an attack of smallpox that left him in a depressed state and compelled him to take a long holiday.His father wrote him a letter of encouragement saying: " It is indeed a mistake to believe thyself required to bear burthens on account of the states of others, whilst in fact thou hast to suspend even the pursuit of thine own avocation."Fortunately he soon recovered his mental poise, but all through his life he retained that same deep pity for human ills.In his medical course at University College he came under the influence of several distinguished men-William Sharpey, Wharton Jones, John Erichsen, R. E. Grant, Thomas Graham, and Viner Ellis -and he passed the M.B.London, with honours, in 1852.In the same year he obtained the F.R.C.S. England.Towards the end of his time at University College he carried out an excellent microscopical research on the involuntary muscles of the iris and skin.
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TL;DR
This biographical article recounts Joseph Lister’s life and the development of antiseptic surgery, from his education and 1867 publications to his later honors. It describes his carbolic acid method, its mixed reception, and his acknowledged debt to Pasteur.
Key findings
- In Lister’s first critical test, between 1865 and 1867 he treated 11 compound fracture cases with carbolic acid and block tin; 9 healed without suppuration, while 2 failed—one required amputation and one patient died from secondary haemorrhage.
- On 20 April 1867 he used carbolic acid as a lotion and antiseptic paste for removal of a tumour from a man’s arm; over the next four months he used the method for several amputations and a large ventral hernia, reporting these cases to the BMA in Dublin in August 1867.
- His technique included washing skin with 1 in 20 carbolic lotion rather than soap and water, soaking instruments in similar solution for 15 minutes, and soaking hands; from 1871 to 1887 he also used a spray of 1 in 100 carbolic lotion, later found unnecessary.
- Reception was mixed: junior British surgeons welcomed the system, seniors tried it half-heartedly, and German surgeons such as Thiersch, von Volkmann, von Nussbaum, and von Bergmann praised it; by 1890 nearly the whole surgical world had accepted it.
Methods
- This is a biographical/historical narrative, not an empirical study; no sample, data collection, or statistical analysis is stated.
- It draws on Lister’s publications, addresses, letters, and reminiscences to trace his education, appointments, antiseptic cases, technique changes, reception, and honors.
- The main approach is chronological description rather than systematic analysis.
Limitations
- Not stated in the paper.
- Evident from the text: it is a celebratory biographical account without formal methods or systematic source appraisal, relying on selected cases, anecdotes, and secondary summaries.
- Evident from the text: some details are inconsistent, such as the Royal Society presidency given as 1895 in the main text but as 1894–1900 in the additional information.
Model-written summary. Check it against the paper before relying on it.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
0 of 6 cited sources checked · 0 supported · 0 flagged
- Findingnone given§ Antiseptic Method
During the succeeding four months, Lister successfully used the antiseptic method for several amputations and for a large ventral hernia that required removal of a great deal of omental fat.
“During the succeeding four months Lister successfully used the antiseptic method for several amputations, and for a large ventral hernia that required removal of a great deal of omental fat.”
Quote in the paperNot a substantial claim - Findingreasoning§ Abstract
Lister became unhappy because so many of his surgical cases developed serious or even fatal septic complications.
“Yet he became unhappy because so many of his surgical cases developed serious or even fatal septic complications.”
Quote in the paperNot a substantial claim - Interpretationreasoning§ Abstract
Lister recognized that microbic infection from the air was the main point.
“Lister at once saw the main point-microbic infection from the air”
Quote in the paperSubstantial claim - Premisecitation§ Abstract
In 1865, during a talk with Professor Thomas Anderson, Lister learned that in France Louis Pasteur had proved that fermentation and putrefaction did not occur in susceptible fluids kept free from contact with air.
“The illuminating idea came in 1865 during a talk with Professor Thomas Anderson, who mentioned that in France the famous chemist Louis Pasteur had proved that fermentation and putrefaction did not occur in susceptible fluids that had been kept free from contact with air”
Quote in the paperSubstantial claim0 of 2 sources checked- cites Professor Thomas Anderson
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- cites Louis Pasteur
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Interpretationown data§ Antiseptic Method
Compared with the usual course of events, the results of the compound fracture series were remarkable.
“Compared with the usual course of events these results were remarkable”
Quote in the paperSubstantial claim- Rests on an assumption: Compound fractures were notoriously subject to serious septic complications, so a high proportion would not heal without suppuration under the usual care.
- Classified as probably not a substantial claim. 22
- May combine two claims. 15
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based). May combine two claims.
Findingnone given§ Debt to PasteurLister was the first surgeon in Britain to use a rubber drainage-tube, and the patient on this occasion was Queen Victoria.
“it was Lister who was the first surgeon in Britain to use a rubber drainage-tube, and the patient on this occasion was none other than Queen Victoria.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingnone given§ Mixed ReceptionIn Britain, the new system was chiefly welcomed by junior surgeons; seniors tried it half-heartedly, if at all.
“In Britain it was chiefly the junior surgeons who welcomed the new system ; the seniors tried it half-heartedly, if at all.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Findingnone given§ Debt to PasteurBy 1890 nearly the whole surgical world had accepted Lister's great innovation.
“By 1890 nearly the whole surgical world had accepted Lister's great innovation”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown data§ Mixed ReceptionAt a meeting of the South London Division of the British Medical Association held at St. Thomas's Hospital in 1879, many surgeons expressed agreement with Lister's views.
“at a meeting of the South London Division of the British Medical Association held at St. Thomas's Hospital in 1879 (at which Lister was present and spoke) many surgeons expressed agreement with his views.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingnone given§ Debt to PasteurLister always acknowledged his great debt to Pasteur, and Pasteur greatly admired Lister's surgical application of his work.
“Lister always acknowledged his great debt to Pasteur, and, on his part, Pasteur greatly admired Lister's surgical application of his work”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown data§ Antiseptic MethodBetween 1865 and 1867, a series of eleven cases of compound fracture were treated with Lister's carbolic acid antiseptic method, of which nine healed without suppuration.
“By this means between 1865 and 1867 a series of eleven cases of com- pound fracture were treated, of which nine healed without suppuration.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingnone given§ Debt to PasteurLister introduced sterilized hardened catgut as suture or ligature material.
“To him we owe the introduction of sterilized hardened catgut as suture or ligature material.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingnone given§ Antiseptic MethodFrom 1871 to 1887 Lister made use of a spray of 1 in 100 carbolic lotion intended to purify the air over the area of operation, but it was found to be unnecessary.
“From 1871 to 1887 Lister also made use of a spray of 1 in 100 carbolic lotion that was intended to purify the air over the area of operation, but it was found to be unnecessary.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown data§ Antiseptic MethodOf the two failures in the compound fracture series, one needed amputation and the other patient died from secondary haemorrhage.
“Of the two failures one needed amputation and the other patient died from secondary haemorrhage.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingreasoning§ Debt to PasteurMany surgeons had adopted the aseptic technique, which, as Lister pointed out, was but a modification of the antiseptic method and sometimes needed antiseptic support.
“Many surgeons had adopted the aseptic technique, which, as Lister pointed out, was but a modification of the antiseptic method and sometimes needed antiseptic support.”
Quote in the paperNot a substantial claim- Rests on an assumption: The microbes that caused sepsis had been identified and cultured by 1890.
Probably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Findingnone given§ Debt to PasteurIn most countries those who tried the antiseptic method valued it.
“In most countries those who tried it valued it.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing), S4 (based).
Findingnone given§ Debt to PasteurLister was probably the first ever to treat varicose veins by the injection of carbolic acid.
“He was probably the first ever to treat varicose veins by the injec- tion of carbolic acid”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingnone given§ Mixed ReceptionLondon was still neutral, if not antagonistic, but in 1877 Lister accepted the invitation to become Professor of Clinical Surgery at King's College Hospital.
“However, London was still neutral, if not antagonistic, but in 1877 Lister accepted the invitation to become Professor of Clinical Surgery at King's College Hospital.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingnone given§ Mixed ReceptionIn 1875 Lister gave a most impressive demonstration of some of his cases before the members of the British Medical Association in Edinburgh.
“In 1875 he gave a most impressive demonstration of some of his cases before the members of the British Medical Association in Edinburgh.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingnone given§ Mixed ReceptionIn 1883, at the meeting of the Medical Society of London, Lister showed six patients on each of whom he had successfully operated for fracture of the patella.
“when in 1883, at the meeting of the Medical Society of London, Lister showed six patients on each of whom he had successfully operated for fracture of the patella”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingnone given§ Mixed ReceptionIn 1869 Lister left Glasgow to succeed Syme as Professor of Clinical Surgery at Edinburgh, and there for eight years he lectured to large classes of students, demonstrated his principles to many visitors from all parts of the world, and practised many operations that had previously been unsafe to attempt.
“In 1869 Lister left Glasgow to succeed Syme as Professor of Clinical Surgery at Edinburgh, and there for eight years he lectured to large classes of students, demonstrated his principles to the many visitors from all parts of the world, and practised many operations that had previously been unsafe to attempt.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingnone given§ Mixed ReceptionIn Germany, many distinguished surgeons-Thiersch, von Volkmann, von Nussbaum, von Bergmann-were loud in their praise of the new technique, and hospitals that had been hotbeds of sepsis were converted.
“In Germany, however, many dis- tinguished surgeons-Thiersch, von Volkmann, von Nussbaum, von Bergmann-were loud in their praise of the new technique, and hospitals that had been hotbeds of sepsis were converted”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Findingnone given§ Debt to PasteurLister devised several useful surgical instruments and invented an aortic tourniquet.
“He also devised several useful surgical instruments and invented an aortic tourniquet.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingnone given§ Antiseptic MethodOn 20 April 1867, Lister operated for removal of a tumour from a man's arm, using carbolic acid as a lotion for the raw wound and applying an antiseptic carbolic paste to the sutured wound; the result was excellent.
“On 20 April 1867 he operated for the removal of a tumour from a man's arm, usingfoot_1 infoot_2 carbolic acid as a lotion for the raw wound, and applying an antiseptic carbolic paste to the sutured wound.The result was excellent.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Premisecitation§ AbstractLockjaw, erysipelas, blood-poisoning of various kinds, and hospital gangrene were never absent from the hospital wards at any one time, and repeatedly gangrene and pyaemia-a most fatal form of blood-poisoning-became alarmingly epidemic.
“Lockjaw, erysipelas, blood-poisoning of various kinds, and hospital gangrene were never absent from the hospital wards at any one time, and repeatedly gangrene and pyaemia-a most fatal form of blood-poisoning-became alarmingly epidemic.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Hector Cameron
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Probably not a substantial claim: may not pass S3 (load-bearing).
Interpretationreasoning§ AbstractJoseph Lister's education and upbringing prepared him for a life of scientific research.
“Joseph Lister's education and upbringing prepared him for a life of scientific research.”
Quote in the paperNot a substantial claimMay combine two claims.
Premisecitation§ AbstractAs early as 1855 Lister had shown Batty Tuke a wound that was healing without suppuration, and had said that the main object of his life was to find out how to procure this result in all wounds.
“Lister had worried about hospital sepsis at Edinburgh, and Godlee relates that as early as 1855 Lister had shown Batty Tuke a wound that was healing without suppuration”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Godlee
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Probably not a substantial claim: may not pass S3 (load-bearing).
Premisecitation§ Additional informationLister founded the antiseptic treatment of wounds in surgery on the basis of the germ theory.
“The philosophical investigations of Pasteur long since made me a convert to the Germ Theory, and it was on the basis of that theory that I founded the antiseptic treatment of wounds in surgery.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Lister, J., Trans.roy.Soc.Edinb., 1875, Vol.27.
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Probably not a substantial claim: may not pass S3 (load-bearing).
Interpretationreasoning§ Mixed ReceptionThe new doctrine met with a mixed reception.
“The new doctrine met with a mixed reception.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Interpretationreasoning§ Mixed ReceptionLister was now world-renowned, and a visit he paid to some of the German universities developed into a triumphal progress.
“He was now world-renowned, and a visit he paid to some of the German universities developed into a triumphal progress.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Premisecitation§ AbstractPasteur had shown that the common souring of milk and the fermentation of grape-juice were caused by the growth and action of minute living particles (microbes) that could be carried in the air.
“moreover, he had shown that the common souring of milk and the fermentation of grape-juice were caused by the growth and action of minute living particles (microbes) that could be carried in the air.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Pasteur
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
The paper relies on this without support.
Compound fractures were notoriously subject to serious septic complications, so a high proportion would not heal without suppuration under the usual care.
“As a critical test he tried it first on a series of cases of compound fracture, which were notoriously subject to serious septic complications.”
The paper relies on this without support.
Carbolic acid, or its impure form creosote, had been successful in purifying and deodorizing the sewage of Carlisle.
“As an antiseptic shield he chose carbolic acid, of which an impure form (creosote) had been successful in purifying and deodorizing the sewage of Carlisle.”
The paper relies on this without support.
The microbes that caused sepsis had been identified and cultured by 1890.
“by this time the microbes that caused sepsis had been identified and cultured.”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Conflicting dates for the start of Lister's Royal Society presidency
MinorThe main text says Lister became President of the Royal Society in 1895, while the additional information dates his presidency from 1894 to 1900.
“In 1895 he became President of the Royal Society”
“he was the President from 1894 to 1900”
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- Authors
- Cope, Z.
- Corresponding author
- Cope, Z.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1967-04-01
- Volume
- 2
- Issue
- 5543
- Pages
- 7-8
- ISSN
- 0007-1447 (ISSN-L)
- 1468-5833
- PMC
- PMC1841130
- OpenAlex
- W2077445477
- Semantic Scholar
- 26d5a65aa909e54f82fcc7298952860316fced0a
- Cited by
- 13
- References
- 0
- Citations by year
- 2025: 1 · 2022: 3 · 2018: 1 · 2017: 1 · 2012: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
- Locations
- BMJ (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Arts and Humanities › History › Medical History and Innovations
- Health Sciences › Medicine › Neurology › History of Medical Practice
- Social Sciences › Arts and Humanities › History and Philosophy of Science › History of Science and Medicine
- Keywords
- Joseph Lister, history of surgery, antiseptic surgery, open fractures, surgical site infection, University College London, Quakers, 19th-century surgery, surgical training, chromatic aberration correction, Thomas Graham
- MeSH terms
- Antisepsis, United Kingdom, Surgical Wound Infection, History, 19th Century
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