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Cited by 44Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryThyroid Cancer Diagnosis and Treatment

Combined Thyroxine and Triiodothyronine for Thyroid Replacement Therapy

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Taylor, Selwyn, Kapur, M., Adie, Ross·1970·BMJ
DOI 10.1136/bmj.2.5704.270PMC PMC1700438
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Abstract

Tablets containing 50μg. of thyroxine and 15μg. of triiodothyronine have been used to treat patients with hypothyroidism of varied aetiology. Following total thyroidectomy a daily dose of three tablets—that is, 150μg. of thyroxine and 45μg. of triiodothyronine—maintained patients in a euthyroid state and produced a protein-bound iodine level within the normal range. The preparation is preferable to dried thyroid because of uniformity of activity and speed of action, and when the patient is clinically euthyroid the P.B.I. falls within the normal range.

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  • Physicians in the United Kingdom and the United States concluded in the 1960s that only treatment with LT4+LT3 was able to resolve symptoms and restore thyroid hormone levels as assessed through protein-bound iodine levels.

    “Indeed, physicians in the United Kingdom and the United States concluded back in the 1960s that only treatment with LT4+LT3 was able to resolve symptoms and restore TH levels (as assessed through protein-bound iodine levels) (12–14).”

    From Emerging Therapies in Hypothyroidism (2024) · cites this paper as [12]

    The Abstract reports that combined T4/T3 treatment maintained patients after total thyroidectomy in a euthyroid state with protein-bound iodine in the normal range. The Introduction and discussion support its value for some patients, but not the claim that it was the only treatment able to resolve symptoms; the discussion limits the problem with T4 alone to a very small group. This paper also does not establish a conclusion by physicians in both the United Kingdom and the United States in the 1960s. (LLM, conf=0.88)

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Research works printed but not linked: 2

  1. Braverman, L. E., and Ingbar, S. H. (1964). New England journal of Medicine, 270, 439.
  2. Gonorrhoea with Skin and Joint Manifestations C. B. WOLFF,* M.B., M.R.C.P.; HELENA V. GOODMAN,t D.M., F.R.C.S., D.PHYS.MED.; J. VAHRMAN,t M.B., M.R.C.P.ED., C.P.H. British Medical 7ournal, 1970, 2, 271-274 Summary: Three cases of gonorrhoea with pyrexia and lesions of the skin and joints (benign gonococcaemia) seen in one hospital group in 1969 within four months of one another are described. All three patients improved rapidly with penicillin therapy. This syndrome is com- moner than is usually thought. It must therefore be borne in mind when a diagnosis is in doubt in a patient with unusual skin lesions and joint involvement. Thorough bacteriological investigation is necessary before starting treatment. The relevant literature is reviewed.

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Authors
Taylor, S., Kapur, M., & Adie, R.
Venue
BMJ
Publisher
BMJ
Published
1970-05-02
Volume
2
Issue
5704
Pages
270-271
ISSN
  • 0007-1447 (ISSN-L)
  • 1468-5833
DOI
10.1136/bmj.2.5704.270
PMC
PMC1700438
OpenAlex
W2033265097
Cited by
44
References
5
Citations by year
2025: 1 · 2023: 2 · 2022: 2 · 2021: 5 · 2019: 3 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 1
FWCI
4.16
Type
journal article
Language
en
Open access
Licence
www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
Locations
  • BMJ (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
thyroxine, triiodothyronine, hypothyroidism, total thyroidectomy, protein-bound iodine
MeSH terms
Blood Proteins, Humans, Hypothyroidism, Iodine, Protein Binding, Thyroidectomy, Thyroxine, Triiodothyronine

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