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Comparison of Streptokinase and Heparin in Treatment of Isolated Acute Massive Pulmonary Embolism
Open accessAbstract
Massive pulmonary embolism was confirmed by pulmonary arteriography in 23 patients. All were seen between 2 and 48 hours after the onset of embolism and none had pre-existing cardiorespiratory disease. Fifteen were treated with streptokinase and eight with heparin. Factors which might influence prognosis and rate of resolution were similar in the patients in each group, and there was no significant difference between the groups in terms of pretreatment haemodynamic or arteriographic findings. Haemodynamic and arteriographic findings after treatment for 72 hours provided an objective measurement of resolution, which was significantly greater in the streptokinase-treated patients. There was no mortality in either group, but treatment had to be changed in two heparin-treated patients because of clinical deterioration. The principal complication of treatment, seen more often in the streptokinase-treated patients, was bleeding from cut-down or operation sites.
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Cited by
2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism
Authors/Task Force Members, Konstantinides, S. V., Torbicki, A., Agnelli, G., Danchin, N., Fitzmaurice, D., Galiè, N., Gibbs, J. S. R., Huisman, M. V., Humbert, M., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu283 · Cited by 3,128
Incidence of Chronic Thromboembolic Pulmonary Hypertension after Pulmonary Embolism
Pengo, V., Lensing, A. W. A., Prins, M. H., Marchiori, A., Davidson, B. L., Tiozzo, F., Albanese, P., Biasiolo, A., Pegoraro, C., Iliceto, S., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032274 · Cited by 1,828
Wan, S., Quinlan, D. J., Agnelli, G., & Eikelboom, J. W. (2004) · Circulation · doi:10.1161/01.cir.0000137826.09715.9c · Cited by 616
Ghaye, B., Ghuysen, A., Willems, V., Lambermont, B., Gerard, P., D'Orio, V., Gevenois, P. A., & Dondelinger, R. F. (2006) · Radiology · doi:10.1148/radiol.2392050075 · Cited by 263
Metadata
- Authors
- Miller, G. A. H., Sutton, G. C., Kerr, I. H., Gibson, R. V., & Honey, M.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1971-06-19
- Volume
- 2
- Issue
- 5763
- Pages
- 681-684
- ISSN
- 0007-1447 (ISSN-L)
- 1468-5833
- OpenAlex
- W2060548555
- Cited by
- 402
- References
- 0
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Miller, G. A. H., Sutton, G. C., Kerr, I. H., Gibson, R. V., & Honey, M. (1971). Comparison of Streptokinase and Heparin in Treatment of Isolated Acute Massive Pulmonary Embolism. BMJ. https://doi.org/10.1136/bmj.2.5763.681
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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