2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism
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Association (HFA), ESC Councils: Council on Cardiovascular Nursing and Allied Professions (CCNAP), Council for Cardiology Practice (CCP), Council on Cardiovascular Primary Care (CCPC) ESC Working Groups:
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Current guidelines suggest extended (ie, indefinite) anticoagulation in patients with unprovoked proximal deep vein thrombosis or pulmonary embolism who have a non-high bleeding risk.
“current guidelines suggest extended (ie, indefinite) anticoagulation in patients with unprovoked proximal deep vein thrombosis or pulmonary embolism who have a non-high bleeding risk.6 7 8”
From Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: systematic review and meta-analysis (2019) · cites this paper as [7]
Section 6 (page not available in our copy) says indefinite anticoagulation should be considered after a first unprovoked proximal DVT or PE, but specifies low bleeding risk, not the broader category of non-high bleeding risk. It also conditions the decision on patient preference and calls for periodic reassessment; ‘indefinite’ does not necessarily mean lifelong treatment. (LLM, conf=0.88)
Experimental — accuracy not yet measuredIt is unlikely that patients with a major bleeding risk that exceeds 3% a year would ever experience a net long term mortality benefit from indefinite anticoagulation.
“as suggested by current guidelines,6 7 it is unlikely that patients with a major bleeding risk that exceeds 3% a year would ever experience a net long term mortality benefit from indefinite anticoagulation.”
From Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: systematic review and meta-analysis (2019) · cites this paper as [7]
Section 6 (Duration of anticoagulation; page unavailable) says the decision to continue anticoagulation depends on the balance between recurrent VTE and bleeding risk, and recommends considering indefinite treatment after a first unprovoked PE when bleeding risk is low. It does not give a 3%-per-year cutoff or conclude that patients above it are unlikely to gain a long-term mortality benefit. (LLM, conf=0.85)
Experimental — accuracy not yet measured
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Self-citationDuration of anticoagulant therapy for deep vein thrombosis and pulmonary embolism
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Thrombolytic Therapy for Pulmonary Embolism
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Thrombolytic therapy in pregnancy
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The relationship between inflammation and venous thrombosis
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Pulmonary tumor embolism: a review of the literature
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Self-citationRisk assessment for recurrent venous thrombosis
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Performance of 4 Clinical Decision Rules in the Diagnostic Management of Acute Pulmonary Embolism
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POTASSIUM CHLORIDE AND INTESTINAL ULCERATION.
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Flagged first, then by citations
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2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429 · see citing works
Self-citation2016 ESC Guidelines for the Diagnosis and Treatment of Acute and Chronic Heart Failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.592 · Cited by 5,866 · see citing works
Self-citationCollet, J.-P., Thiele, H., Barbato, E., Barthélémy, O., Bauersachs, J., Bhatt, D. L., Dendale, P., Dorobantu, M., Edvardsen, T., Folliguet, T., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehaa575 · Cited by 5,037 · see citing works
Self-citationAntithrombotic Therapy for VTE Disease
Kearon, C., Akl, E. A., Ornelas, J., Blaivas, A., Jimenez, D., Bounameaux, H., Huisman, M., King, C. S., Morris, T. A., Sood, N., et al. (2016) · Chest · doi:10.1016/j.chest.2015.11.026 · Cited by 4,830 · see citing works
Self-citation2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy
Regitz-Zagrosek, V., Roos-Hesselink, J. W., Bauersachs, J., Blomström-Lundqvist, C., Cífková, R., De Bonis, M., Iung, B., Johnson, M. R., Kintscher, U., Kranke, P., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy340 · Cited by 2,292 · see citing works
Self-citationBates, S. M., Rajasekhar, A., Middeldorp, S., McLintock, C., Rodger, M. A., James, A. H., Vazquez, S. R., Greer, I. A., Riva, J. J., Bhatt, M., et al. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018024802 · Cited by 625 · see citing works
Mehta, L. S., Warnes, C. A., Bradley, E., Burton, T., Economy, K., Mehran, R., Safdar, B., Sharma, G., Wood, M., Valente, A. M., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000772 · Cited by 464 · see citing works
Guidance for the treatment and prevention of obstetric-associated venous thromboembolism
Bates, S. M., Middeldorp, S., Rodger, M., James, A. H., & Greer, I. (2016) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-015-1309-0 · Cited by 441 · see citing works
Mazzolai, L., Aboyans, V., Ageno, W., Agnelli, G., Alatri, A., Bauersachs, R., Brekelmans, M. P. A., Büller, H. R., Elias, A., Farge, D., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehx003 · Cited by 402 · see citing works
Self-citationKhan, F., Rahman, A., Carrier, M., Kearon, C., Weitz, J. I., Schulman, S., Couturaud, F., Eichinger, S., Kyrle, P. A., Becattini, C., et al. (2019) · BMJ · doi:10.1136/bmj.l4363 · Cited by 328 · see citing works
Self-citationCouturaud, F., Sanchez, O., Pernod, G., Mismetti, P., Jego, P., Duhamel, E., Provost, K., dit Sollier, C. B., Presles, E., Castellant, P., et al. (2015) · JAMA · doi:10.1001/jama.2015.7046 · Cited by 249 · see citing works
Self-citationA Multidisciplinary Pulmonary Embolism Response Team
Kabrhel, C., Rosovsky, R., Channick, R., Jaff, M. R., Weinberg, I., Sundt, T., Dudzinski, D. M., Rodriguez-Lopez, J., Parry, B. A., Harshbarger, S., et al. (2016) · CHEST · doi:10.1016/j.chest.2016.03.011 · Cited by 245 · see citing works
Rodger, M. A., Le Gal, G., Anderson, D. R., Schmidt, J., Pernod, G., Kahn, S. R., Righini, M., Mismetti, P., Kearon, C., Meyer, G., et al. (2017) · BMJ · doi:10.1136/bmj.j1065 · Cited by 238 · see citing works
Self-citationFanaroff, A. C., Califf, R. M., Windecker, S., Smith, S. C., & Lopes, R. D. (2019) · JAMA · doi:10.1001/jama.2019.1122 · Cited by 228 · see citing works
Self-citationHigh-sensitivity assays for troponin in patients with cardiac disease
Westermann, D., Neumann, J. T., Sörensen, N. A., & Blankenberg, S. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.48 · Cited by 222 · see citing works
Florkowski, C., Don-Wauchope, A., Gimenez, N., Rodriguez-Capote, K., Wils, J., & Zemlin, A. (2017) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2017.1399336 · Cited by 189 · see citing works
Rosovsky, R., Chang, Y., Rosenfield, K., Channick, R., Jaff, M. R., Weinberg, I., Sundt, T., Witkin, A., Rodriguez-Lopez, J., Parry, B. A., et al. (2019) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-018-1737-8 · Cited by 168 · see citing works
Xenos, E. S., Davis, G. A., He, Q., Green, A., & Smyth, S. S. (2019) · Journal of Vascular Surgery: Venous and Lymphatic Disorders · doi:10.1016/j.jvsv.2018.11.014 · Cited by 85 · see citing works
Agarwal, S., Clark, D., Sud, K., Jaber, W. A., Cho, L., & Menon, V. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2015.07.048 · Cited by 79 · see citing works
Integrated diagnostics: the future of laboratory medicine?
Lippi, G., & Plebani, M. (2020) · Biochemia medica · doi:10.11613/bm.2020.010501 · Cited by 64 · see citing works
Reducing the hospital burden associated with the treatment of pulmonary embolism
Peacock, W. F., & Singer, A. J. (2019) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14423 · Cited by 37 · see citing works
Keller, K., Schmitt, V. H., Vosseler, M., Brochhausen, C., Münzel, T., Hobohm, L., & Espinola-Klein, C. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10215033 · Cited by 31 · see citing works
Liang, N. L., Avgerinos, E. D., Singh, M. J., Makaroun, M. S., & Chaer, R. A. (2017) · Journal of Vascular Surgery: Venous and Lymphatic Disorders · doi:10.1016/j.jvsv.2016.11.005 · Cited by 29 · see citing works
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Self-citation
- Authors
- Authors/Task Force Members, Konstantinides, S. V., Torbicki, A., Agnelli, G., Danchin, N., Fitzmaurice, D., Galiè, N., Gibbs, J. S. R., Huisman, M. V., Humbert, M., Kucher, N., Lang, I., Lankeit, M., Lekakis, J., Maack, C., Mayer, E., Meneveau, N., Perrier, A., Pruszczyk, P., Rasmussen, L. H., Schindler, T. H., Svitil, P., Vonk Noordegraaf, A., Zamorano, J. L., Zompatori, M., ESC Committee for Practice Guidelines (CPG), Zamorano, J. L., Achenbach, S., Baumgartner, H., Bax, J. J., Bueno, H., Dean, V., Deaton, C., Erol, Ç., Fagard, R., Ferrari, R., Hasdai, D., Hoes, A., Kirchhof, P., Knuuti, J., Kolh, P., Lancellotti, P., Linhart, A., Nihoyannopoulos, P., Piepoli, M. F., Ponikowski, P., Sirnes, P. A., Tamargo, J. L., Tendera, M., Torbicki, A., Wijns, W., Windecker, S., Reviewers, D., Erol, Ç., Jimenez, D., Ageno, W., Agewall, S., Asteggiano, R., Bauersachs, R., Becattini, C., Bounameaux, H., Büller, H. R., Davos, C. H., Deaton, C., Geersing, G.-J., Sanchez, M. A. G., Hendriks, J., Hoes, A., Kilickap, M., Mareev, V., Monreal, M., Morais, J., Nihoyannopoulos, P., Popescu, B. A., Sanchez, O., & Spyropoulos, A. C.
- Affiliations
- Ferrari (Italy) (IT)
- ORCID
- Konstantinides, Stavros V.
- Agnelli, Giancarlo
- Danchin, Nicolas
- Fitzmaurice, David
- Galiè, Nazzareno
- Gibbs, J. Simon R.
- Huisman, Menno V.
- Humbert, Marc
- Kucher, Nils
- Lang, Irene
- Lankeit, Mareike
- Maack, Christoph
- Meneveau, Nicolas
- Perrier, Arnaud
- Pruszczyk, Piotr
- Schindler, Thomas H.
- Zompatori, Maurizio
- Bax, Jeroen J.
- Ferrari, Roberto
- Hasdai, David
- Kirchhof, Paulus
- Knuuti, Juhani
- Kolh, Philippe
- Lancellotti, Patrizio
- Piepoli, Massimo F.
- Ponikowski, Piotr
- Sirnes, Per Anton
- Tamargo, Juan Luis
- Wijns, William
- Windecker, Stephan
- Ageno, Walter
- Agewall, Stefan
- Asteggiano, Riccardo
- Bauersachs, Rupert
- Becattini, Cecilia
- Davos, Constantinos H.
- Geersing, Geert-Jan
- Hendriks, Jeroen
- Popescu, Bogdan A.
- Sanchez, Olivier
- Spyropoulos, Alex C.
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-08-29
- Volume
- 35
- Issue
- 43
- Pages
- 3033-3069k
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- OpenAlex
- W2120203545
- Cited by
- 3,128
- References
- 493
- Citations by year
- 2026: 42 · 2025: 76 · 2024: 107 · 2023: 144 · 2022: 141 · 2021: 228 · 2020: 323 · 2019: 487 · 2018: 453 · 2017: 423 · 2016: 370 · 2015: 297 · 2014: 32 · 2013: 2
- FWCI
- 292.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Heart Journal (publishedVersion)
- PubMed (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- IrInSubria (University of Insubria) (submittedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- ORBi (University of Liège) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Funders
- Sociedad Española de Cardiología
- British Cardiovascular Society
- Société Française de Cardiologie
- Hellenic Cardiological Society
- Türk Kardiyoloji Derneği
- Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.
- Slovenská Kardiologická Spoločnost
- Österreichische Kardiologische Gesellschaft
- Sociedade Portuguesa de Cardiologia
- Suomen Kardiologinen Seura
- Topics
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Keywords
- acute pulmonary embolism, diagnosis, management, venous thromboembolism
- MeSH terms
- Administration, Oral, Algorithms, Anticoagulants, Chronic Disease, Diagnostic Imaging, Female, Fibrin Fibrinogen Degradation Products, Fibrinolytic Agents, Heart Failure, Home Care Services, Humans, Hypertension, Pulmonary, Long-Term Care, Neoplasms, Pregnancy, Pregnancy Complications, Cardiovascular, Prognosis, Pulmonary Embolism, Risk Factors, Vasoconstrictor Agents, Vasodilator Agents, Vitamin K, Biomarkers, Embolectomy, Clinical Laboratory Techniques, Endovascular Procedures
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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