Cited by 3,128Venous Thromboembolism Diagnosis and ManagementCardiovascular and Diving-Related ComplicationsAcute Myocardial Infarction Research

2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism

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Authors/Task Force Members, Konstantinides, Stavros V., Torbicki, Adam, Agnelli, Giancarlo, Danchin, Nicolas, Fitzmaurice, David, Galiè, Nazzareno, Gibbs, J. Simon R. +68 more·2014·European Heart Journal

Abstract

Association (HFA), ESC Councils: Council on Cardiovascular Nursing and Allied Professions (CCNAP), Council for Cardiology Practice (CCP), Council on Cardiovascular Primary Care (CCPC) ESC Working Groups:

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Registry

Crossref · 10.1093/eurheartj/ehu283

Cites

493 of 493 references verified0 citation errors · 0 not checkable

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  • Current guidelines suggest extended (ie, indefinite) anticoagulation in patients with unprovoked proximal deep vein thrombosis or pulmonary embolism who have a non-high bleeding risk.

    “current guidelines suggest extended (ie, indefinite) anticoagulation in patients with unprovoked proximal deep vein thrombosis or pulmonary embolism who have a non-high bleeding risk.6 7 8”

    From Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: systematic review and meta-analysis (2019) · cites this paper as [7]

    Section 6 (page not available in our copy) says indefinite anticoagulation should be considered after a first unprovoked proximal DVT or PE, but specifies low bleeding risk, not the broader category of non-high bleeding risk. It also conditions the decision on patient preference and calls for periodic reassessment; ‘indefinite’ does not necessarily mean lifelong treatment. (LLM, conf=0.88)

    Experimental — accuracy not yet measured
  • It is unlikely that patients with a major bleeding risk that exceeds 3% a year would ever experience a net long term mortality benefit from indefinite anticoagulation.

    “as suggested by current guidelines,6 7 it is unlikely that patients with a major bleeding risk that exceeds 3% a year would ever experience a net long term mortality benefit from indefinite anticoagulation.”

    From Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: systematic review and meta-analysis (2019) · cites this paper as [7]

    Section 6 (Duration of anticoagulation; page unavailable) says the decision to continue anticoagulation depends on the balance between recurrent VTE and bleeding risk, and recommends considering indefinite treatment after a first unprovoked PE when bleeding risk is low. It does not give a 3%-per-year cutoff or conclude that patients above it are unlikely to gain a long-term mortality benefit. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

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Authors
Authors/Task Force Members, Konstantinides, S. V., Torbicki, A., Agnelli, G., Danchin, N., Fitzmaurice, D., Galiè, N., Gibbs, J. S. R., Huisman, M. V., Humbert, M., Kucher, N., Lang, I., Lankeit, M., Lekakis, J., Maack, C., Mayer, E., Meneveau, N., Perrier, A., Pruszczyk, P., Rasmussen, L. H., Schindler, T. H., Svitil, P., Vonk Noordegraaf, A., Zamorano, J. L., Zompatori, M., ESC Committee for Practice Guidelines (CPG), Zamorano, J. L., Achenbach, S., Baumgartner, H., Bax, J. J., Bueno, H., Dean, V., Deaton, C., Erol, Ç., Fagard, R., Ferrari, R., Hasdai, D., Hoes, A., Kirchhof, P., Knuuti, J., Kolh, P., Lancellotti, P., Linhart, A., Nihoyannopoulos, P., Piepoli, M. F., Ponikowski, P., Sirnes, P. A., Tamargo, J. L., Tendera, M., Torbicki, A., Wijns, W., Windecker, S., Reviewers, D., Erol, Ç., Jimenez, D., Ageno, W., Agewall, S., Asteggiano, R., Bauersachs, R., Becattini, C., Bounameaux, H., Büller, H. R., Davos, C. H., Deaton, C., Geersing, G.-J., Sanchez, M. A. G., Hendriks, J., Hoes, A., Kilickap, M., Mareev, V., Monreal, M., Morais, J., Nihoyannopoulos, P., Popescu, B. A., Sanchez, O., & Spyropoulos, A. C.
Affiliations
Ferrari (Italy) (IT)
Venue
European Heart Journal
Published
2014-08-29
Volume
35
Issue
43
Pages
3033-3069k
ISSN
  • 0195-668X (ISSN-L)
  • 1522-9645
OpenAlex
W2120203545
Cited by
3,128
References
493
Citations by year
2026: 42 · 2025: 76 · 2024: 107 · 2023: 144 · 2022: 141 · 2021: 228 · 2020: 323 · 2019: 487 · 2018: 453 · 2017: 423 · 2016: 370 · 2015: 297 · 2014: 32 · 2013: 2
FWCI
292.74
Type
journal article
Language
en
Open access
Locations
  • European Heart Journal (publishedVersion)
  • PubMed (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • SZTE Publicatio Repozitórium (University of Szeged) (acceptedVersion, other-oa)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Leiden Repository (Leiden University) (submittedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
  • IrInSubria (University of Insubria) (submittedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
  • ORBi (University of Liège) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
  • VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
  • Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
  • Padua Research Archive (University of Padova) (submittedVersion)
Funders
  • Sociedad Española de Cardiología
  • British Cardiovascular Society
  • Société Française de Cardiologie
  • Hellenic Cardiological Society
  • Türk Kardiyoloji Derneği
  • Deutsche Gesellschaft für Kardiologie-Herz und Kreislaufforschung.
  • Slovenská Kardiologická Spoločnost
  • Österreichische Kardiologische Gesellschaft
  • Sociedade Portuguesa de Cardiologia
  • Suomen Kardiologinen Seura
Topics
  • Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Keywords
acute pulmonary embolism, diagnosis, management, venous thromboembolism
MeSH terms
Administration, Oral, Algorithms, Anticoagulants, Chronic Disease, Diagnostic Imaging, Female, Fibrin Fibrinogen Degradation Products, Fibrinolytic Agents, Heart Failure, Home Care Services, Humans, Hypertension, Pulmonary, Long-Term Care, Neoplasms, Pregnancy, Pregnancy Complications, Cardiovascular, Prognosis, Pulmonary Embolism, Risk Factors, Vasoconstrictor Agents, Vasodilator Agents, Vitamin K, Biomarkers, Embolectomy, Clinical Laboratory Techniques, Endovascular Procedures

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