The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Anxiety caused by a short-life hypnotic.
Open accessAbstract
A comprehensive understanding of the changes in gene expression in cell types involved in idiopathic pulmonary fibrosis (IPF) will shed light on the mechanisms underlying the loss of alveolar epithelial cells, and development of honeycomb cysts and fibroblastic foci. We sought to understand changes in IPF lung cell transcriptomes and gain insight into innate immune aspects of pathogenesis. We investigated IPF pathogenesis using single cell RNA-sequencing of fresh lung explants, comparing human IPF fibrotic lower lobes reflecting late disease, upper lobes reflecting early disease and normal lungs. IPF lower lobes showed increased fibroblasts, and basal, ciliated, goblet and club cells, but decreased alveolar epithelial cells, and marked alterations in inflammatory cells. We found three discrete macrophage subpopulations in normal and fibrotic lungs, one expressing monocyte markers, one highly expressing FABP4 and INHBA (FABP4hi), and one highly expressing SPP1 and MERTK (SPP1hi). SPP1hi macrophages in fibrotic lower lobes showed highly upregulated SPP1 and MERTK expression. Low-level local proliferation of SPP1hi macrophages in normal lungs was strikingly increased in IPF lungs. Co-localisation and causal modelling supported the role for these highly proliferative SPP1hi macrophages in activation of IPF myofibroblasts in lung fibrosis. These data suggest SPP1hi macrophages contribute importantly to lung fibrosis in IPF, and that therapeutic strategies targeting MERTK and macrophage proliferation may show promise for treatment of this disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These symptoms are more severe following withdrawal from short rather than long half-life BZDs [39,40,41,42,43].”
From Cognitive behavioral therapy and acceptance and commitment therapy for the discontinuation of long-term benzodiazepine use in insomnia and anxiety disorders (2021) · cites this paper as [40]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The prevalence of rebound insomnia was found to be significantly lower in all benzodiazepines compared to triazolam [52, 60-69] and was lower than that with triazolam.”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [63]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Dexamethasone Proves Deleterious in Cerebral Malaria
Warrell, D. A., Looareesuwan, S., Warrell, M. J., Kasemsarn, P., Intaraprasert, R., BUNNAG, D., & Harinasuta, T. (1982) · New England Journal of Medicine · doi:10.1056/nejm198202113060601 · Cited by 485
Withdrawal from long-term benzodiazepine treatment
Petursson, H., & Lader, M. H. (1981) · BMJ · doi:10.1136/bmj.283.6292.643 · Cited by 367
van der Kroef, C. (1979) · The Lancet · doi:10.1016/s0140-6736(79)91578-2 · Cited by 95
Anxiety and sleep after fosazepam.
Allen, S., & Oswald, I. (1976) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1976.tb00584.x · Cited by 43
Self-citationTwo Anti-anxiety Drugs: A Psychoneuroendocrine Study
Ogunremi, O. O., Adamson, L., Březinová, V., Hunter, W. M., Maclean, A. W., Oswald, I., & PERCY-ROBB, I. W. (1973) · BMJ · doi:10.1136/bmj.2.5860.202 · Cited by 41
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–137 of 137
Nutley, P. G. (1983) · BMJ · doi:10.1136/bmj.287.6387.290 · Cited by 2
Managing Double Binds in the Pharmaceutical Prescription Market: The Case of Halcion
Pieters, T., & Snelders, S. (2013) · Palgrave Macmillan UK eBooks · doi:10.1057/9781137291523_12 · Cited by 2
Oswald, I. (1984) · Psychopharmacology series · doi:10.1007/978-3-642-69659-6_7 · Cited by 2
Self-citationReflexions sur la place des enregistrements polygraphiques dans l'etude des hypnotiques
Goldenberg, F. (1988) · Neurophysiologie Clinique · doi:10.1016/s0987-7053(88)80027-3 · Cited by 2
Triazolam. Triazolam condemned by misinformation...
Jonas, J. M. (1993) · BMJ · doi:10.1136/bmj.306.6890.1476 · Cited by 2
Sleep disorders. Consider nocturnal paroxysmal dystonia.
Borrow, S., Tattersall, M. L., Hartman, D. L., Oakey, M., Sedgwick, P. M., & Crisp, A. H. (1993) · BMJ · doi:10.1136/bmj.306.6890.1476-c · Cited by 1
Johnson, R. E., McFarland, B. H., & Woodson, G. T. (1997) · Medical Care · doi:10.1097/00005650-199704000-00002 · Cited by 1
Cormack, M. A. (1986) · Springer eBooks · doi:10.1007/978-1-4615-6775-2_21 · Cited by 1
Brotizolam versus triazolam for the treatment of insomnia in anxious patients
Smirne, S., Cassano, G., Ferrillo, F., Maggini, C., Puca, F., Scarone, S., Terzano, M. G., & Moroni, M. (1993) · Current Therapeutic Research · doi:10.1016/s0011-393x(05)80149-3 · Cited by 1
Risks of dependence on benzodiazepine drugs
Cohen, S. I. (1989) · BMJ · doi:10.1136/bmj.298.6671.456-c · Cited by 1
A Possible Cause of Benzodiazepine Tolerance
Petersen, E. N. (1989) · Nordic Journal of Psychiatry · doi:10.3109/08039488909101969 · Cited by 1
Kriterien für die Auswahl eines Schlafmittels
Oswald, I., & Adám, K. (1988) · Vieweg+Teubner eBooks · doi:10.1007/978-3-663-20215-8_5 · Cited by 1
Self-citationMechanisms of Benzodiazepine Drug Dependence
Vgontzas, A. N., & Kales, A. (1995) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57836-6_19 · Cited by 1
Effect of Triazolam on Pilot Performance.
Caldwell, J. L., Caldwell, J. A., Sprenger, W. D., Woodrum, L. C., & Jones, H. D. (1996) · Cited by 1
Kales, A., Vgontzas, A. N., & Bixler, E. O. (1995) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57836-6_13 · Cited by 1
Jerram, T. C. (1983) · Side effects of drugs annual · doi:10.1016/s0378-6080(83)80009-9 · Cited by 1
Kales, A. (1983) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1983.tb03241.x · Cited by 1
Risks of dependence on benzodiazepine drugs.
(1989) · BMJ · doi:10.1136/bmj.298.6671.456-b · Cited by 1
Hockings, N. (1983) · BMJ · doi:10.1136/bmj.287.6387.290-a · Cited by 1
TREATMENT OF BENZODIAZEPINE DEPENDENCE
(1987) · The Lancet · doi:10.1016/s0140-6736(87)91913-1 · Cited by 1
Therapeutic focus: Management of insomnia
LADER, M. H. (1990) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.1990.tb10758.x · Cited by 1
Dr. Hudson and Associates Reply
Hudson, J. I., Hudson, M., Pliner, L. F., Goldenberg, D. L., & Pope, H. G. (1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.6.813
Sleep disorders. Epilepsy a differential diagnosis in children.
Staufenberg, E. F. A. (1993) · BMJ · doi:10.1136/bmj.306.6890.1476-b
Triazolam. ...and selective referencing.
Burton, G., & Carter, C. (1993) · BMJ · doi:10.1136/bmj.306.6890.1476-a
What do psychiatric inpatients really want?
White, A., & Jones, E. (1989) · BMJ · doi:10.1136/bmj.298.6671.456-a
Which is more dangerous—cycling or flying?
Forrester, J. (1983) · BMJ · doi:10.1136/bmj.287.6387.290-c
Oswald, I. (1984) · Irish Journal of Medical Science (1971 -) · doi:10.1007/bf02939899
Self-citationWhat Caused the Mania in Two Sisters?
KRASNOW, C. G. (1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.6.814-a
The Future of Anxiolytic Drug Therapy
Ayd, F. J. (1990) · International Review of Psychiatry · doi:10.3109/09540269009026608
Louden, G. (2016) · Biographies | United Kingdom Encyclopedia of Law
Jerram, T. C. (1992) · Side effects of drugs annual · doi:10.1016/s0378-6080(05)80485-4
Lemoine, P. (2004) · Encyclopédie médico-chirurgicale. Psychiatrie · doi:10.1016/s0246-1072(02)00084-6
Bretland, P. M. (1989) · BMJ · doi:10.1136/bmj.298.6671.456
(1989) · BMJ · doi:10.1136/bmj.298.6671.455-b
Bliwise, D. L. (1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.6.814
Benzodiazepines: half-life and daytime hyperarousal
(1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.6.aj1436813
Hypnotics and CNS Function in the Aged Patient
Swift, C. G. (1987) · Vieweg+Teubner eBooks · doi:10.1007/978-3-322-89728-2_16
Metadata
- Authors
- Morgan, K., & Oswald, I.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1982-03-27
- Volume
- 284
- Issue
- 6320
- Pages
- 942-942
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W2150408288
- Cited by
- 137
- References
- 5
- Citations by year
- 2023: 1 · 2021: 1 · 2020: 1 · 2016: 1 · 2013: 1
- FWCI
- 26.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Keywords
- idiopathic pulmonary fibrosis, pulmonary fibrosis, MERTK, macrophage proliferation, myofibroblast activation, alveolar epithelial cells, macrophage subpopulations, innate immunity, gene expression, single-cell transcriptomics, honeycomb cysts
- MeSH terms
- Anxiety Disorders, Benzodiazepines, Benzodiazepinones, Clinical Trials as Topic, Double-Blind Method, Female, Half-Life, Humans, Male, Middle Aged, Substance Withdrawal Syndrome, Anti-Anxiety Agents, Triazolam
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
