The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Anxiety caused by a short-life hypnotic.
Open accessAbstract
A comprehensive understanding of the changes in gene expression in cell types involved in idiopathic pulmonary fibrosis (IPF) will shed light on the mechanisms underlying the loss of alveolar epithelial cells, and development of honeycomb cysts and fibroblastic foci. We sought to understand changes in IPF lung cell transcriptomes and gain insight into innate immune aspects of pathogenesis. We investigated IPF pathogenesis using single cell RNA-sequencing of fresh lung explants, comparing human IPF fibrotic lower lobes reflecting late disease, upper lobes reflecting early disease and normal lungs. IPF lower lobes showed increased fibroblasts, and basal, ciliated, goblet and club cells, but decreased alveolar epithelial cells, and marked alterations in inflammatory cells. We found three discrete macrophage subpopulations in normal and fibrotic lungs, one expressing monocyte markers, one highly expressing FABP4 and INHBA (FABP4hi), and one highly expressing SPP1 and MERTK (SPP1hi). SPP1hi macrophages in fibrotic lower lobes showed highly upregulated SPP1 and MERTK expression. Low-level local proliferation of SPP1hi macrophages in normal lungs was strikingly increased in IPF lungs. Co-localisation and causal modelling supported the role for these highly proliferative SPP1hi macrophages in activation of IPF myofibroblasts in lung fibrosis. These data suggest SPP1hi macrophages contribute importantly to lung fibrosis in IPF, and that therapeutic strategies targeting MERTK and macrophage proliferation may show promise for treatment of this disease.
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“These symptoms are more severe following withdrawal from short rather than long half-life BZDs [39,40,41,42,43].”
From Cognitive behavioral therapy and acceptance and commitment therapy for the discontinuation of long-term benzodiazepine use in insomnia and anxiety disorders (2021) · cites this paper as [40]
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“The prevalence of rebound insomnia was found to be significantly lower in all benzodiazepines compared to triazolam [52, 60-69] and was lower than that with triazolam.”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [63]
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Cites
Dexamethasone Proves Deleterious in Cerebral Malaria
Warrell, D. A., Looareesuwan, S., Warrell, M. J., Kasemsarn, P., Intaraprasert, R., BUNNAG, D., & Harinasuta, T. (1982) · New England Journal of Medicine · doi:10.1056/nejm198202113060601 · Cited by 485
Withdrawal from long-term benzodiazepine treatment
Petursson, H., & Lader, M. H. (1981) · BMJ · doi:10.1136/bmj.283.6292.643 · Cited by 367
van der Kroef, C. (1979) · The Lancet · doi:10.1016/s0140-6736(79)91578-2 · Cited by 95
Anxiety and sleep after fosazepam.
Allen, S., & Oswald, I. (1976) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.1976.tb00584.x · Cited by 43
Self-citationTwo Anti-anxiety Drugs: A Psychoneuroendocrine Study
Ogunremi, O. O., Adamson, L., Březinová, V., Hunter, W. M., Maclean, A. W., Oswald, I., & PERCY-ROBB, I. W. (1973) · BMJ · doi:10.1136/bmj.2.5860.202 · Cited by 41
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Jerram, T. C. (1981) · Side effects of drugs annual · doi:10.1016/s0378-6080(81)80009-8 · Cited by 695
Meta-analysis of benzodiazepine use in the treatment of insomnia.
(2000) · PubMed Central · Cited by 613
Guidelines for the Rational Use of Benzodiazepines: When and What to Use
Ashton, H. (1994) · Drugs · doi:10.2165/00003495-199448010-00004 · Cited by 593
Midazolam A Review of its Pharmacological Properties and Therapeutic Use
DUNDEE, J. W., Halliday, N. J., Harper, K. W., & Brogden, R. N. (1984) · Drugs · doi:10.2165/00003495-198428060-00002 · Cited by 357
Benzodiazepine Dependence A Review of the Evidence
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Metadata
- Authors
- Morgan, K., & Oswald, I.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1982-03-27
- Volume
- 284
- Issue
- 6320
- Pages
- 942-942
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W2150408288
- Cited by
- 137
- References
- 5
- Citations by year
- 2023: 1 · 2021: 1 · 2020: 1 · 2016: 1 · 2013: 1
- FWCI
- 26.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Keywords
- idiopathic pulmonary fibrosis, pulmonary fibrosis, MERTK, macrophage proliferation, myofibroblast activation, alveolar epithelial cells, macrophage subpopulations, innate immunity, gene expression, single-cell transcriptomics, honeycomb cysts
- MeSH terms
- Anxiety Disorders, Benzodiazepines, Benzodiazepinones, Clinical Trials as Topic, Double-Blind Method, Female, Half-Life, Humans, Male, Middle Aged, Substance Withdrawal Syndrome, Anti-Anxiety Agents, Triazolam
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