Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis
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Abstract
Human lung single-cell atlas reveals the complexity and diversity of aberrant cellular populations in pulmonary fibrosis.
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Profibrotic macrophage populations dominate the immune cell landscape in IPF.
“In terms of the IPF immune cell compartment, profibrotic macrophage populations dominate the immune cell landscape in IPF (Adams et al., 2020; Habermann et al., 2020).”
From Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies (2023) · cites this paper as Adams et al., 2020
Aberrant basaloid cells are a unique epithelial feature of IPF (and COPD) expressing basal cell, senescence and EMT markers, and appear to overlay fibrotic foci.
“Aberrant basaloid cells have recently been identified as a unique epithelial feature of IPF (and chronic obstructive pulmonary disease) expressing basal cell, senescence and epithelial to mesenchymal transdifferentiation (EMT) markers and appear to overlay fibrotic foci (also known as fibroblastic foci), the histological hallmark of the disease (Adams et al., 2020).”
From Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies (2023) · cites this paper as Adams et al., 2020
Peribronchial vascular endothelial cells, normally restricted to the bronchial circulation, are observed in areas of remodelling and aberrant angiogenesis in IPF.
“Peribronchial vascular endothelial cells, normally restricted to the bronchial circulation, are observed in areas of remodelling and aberrant angiogenesis (Adams et al., 2020).”
From Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies (2023) · cites this paper as Adams et al., 2020
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Self-citation
- Authors
- Adams, T. S., Schupp, J. C., Poli, S., Ayaub, E. A., Neumark, N., Ahangari, F., Chu, S. G., Raby, B. A., DeIuliis, G., Januszyk, M., Duan, Q., Arnett, H. A., Siddiqui, A., Washko, G. R., Homer, R., Yan, X., Rosas, I. O., & Kaminski, N.
- Affiliations
- Yale University (US)
- Brigham and Women's Hospital (US)
- NuMedii, Inc., San Mateo, CA, USA.
- Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.
- Corresponding author
- Kaminski, Naftali
- ORCID
- Venue
- Science Advances
- Published
- 2020-07-10
- Volume
- 6
- Issue
- 28
- Pages
- eaba1983-eaba1983
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC7439502
- OpenAlex
- W3041062936
- Cited by
- 1,420
- References
- 46
- Citations by year
- 2026: 253 · 2025: 251 · 2024: 256 · 2023: 229 · 2022: 208 · 2021: 156 · 2020: 61 · 2019: 5
- FWCI
- 94.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (R01HL127349, U01HL145567, U01HL122626, U54HG008540)
- National Heart, Lung, and Blood Institute (P01 HL114501)
- Deutsche Forschungsgemeinschaft (SCHU 3147/1)
- Pulmonary Fibrosis Fund
- Three Lake Partners (Unrestricted Gift)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Keywords
- idiopathic pulmonary fibrosis, single-cell transcriptomics, myofibroblasts, vascular endothelial cells, macrophages, chronic obstructive pulmonary disease, interstitial lung disease, cellular heterogeneity
- MeSH terms
- RNA-Seq, Humans, Lung, Pulmonary Disease, Chronic Obstructive, Endothelial Cells, Idiopathic Pulmonary Fibrosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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