The DOI matches its Crossref record.
Mechanism of action of antipruritic drugs.
Open accessAbstract
Astemizole and terfenadine, two potent non-sedative H1 antihistamines, had no effect on itch measured objectively as nocturnal scratching and subjectively on a 10 cm line. Trimeprazine, however, a more sedative but less potent H1 antihistamine, was antipruritic, as was nitrazepam, a sedative benzodiazepine. We concluded (a) that antipruritic drugs act centrally by a property related to sedation; (b) H1 receptor antagonists have a peripheral antipruritic action only when itch is due to histamine release, as in the wealing disorders. Thus the new nonsedative H1 antihistamines have no place in the treatment of itch from other causes.
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Cited by
Scratching behavior induced by pruritogenic but not algesiogenic agents in mice
Kuraishi, Y., Nagasawa, T., Hayashi, K., & Satoh, M. (1995) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)00780-b · Cited by 398
Yosipovitch, G., Greaves, M. W., & Schmelz, M. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12570-6 · Cited by 388
Greaves, M. W. (2005) · Skin Pharmacology and Physiology · doi:10.1159/000086667 · Cited by 63
Metadata
- Authors
- Krause, L., & Shuster, S.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1983-10-22
- Volume
- 287
- Issue
- 6400
- Pages
- 1199-1200
- ISSN
- 0007-1447 (ISSN-L)
- 1468-5833
- OpenAlex
- W2090596590
- Cited by
- 173
- References
- 0
- FWCI
- 5.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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