The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Morphine intoxication in renal failure: the role of morphine-6-glucuronide.
Open accessAbstract
Patients with impaired renal function may experience severe and prolonged respiratory depression when treated with morphine. This has been attributed to accumulation of the drug during renal failure. Three patients are described who had classical signs of intoxication with morphine in the absence of measurable quantities of morphine in the plasma. The observed clinical effect is attributed to accumulation of the pharmacologically active metabolite morphine-6-glucuronide, which is usually renally excreted. It is concluded that morphine does not accumulate in patients with renal failure but that accumulation of metabolites does occur. The previously reported observations of morphine accumulation during renal failure probably result from the use of radioimmunoassays that cannot distinguish between morphine and morphine-6-glucuronide. Thus the apparent morphine concentration measured with these assays in fact reflects the total quantity of morphine and morphine-6-glucuronide present.
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Cites
Analgesic Effect of Morphine Glucuronides
SHIMOMURA, K., KAMATA, O., UEKI, S., IDA, S., OGURI, K., YOSHIMURA, H., & TSUKAMOTO, H. (1971) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.105.45 · Cited by 368
Säwe, J. (1986) · Clinical Pharmacokinetics · doi:10.2165/00003088-198611020-00001 · Cited by 194
Selecting optimal treatment in clinical trials using covariate information
Byar, D. P., & Corle, D. K. (1977) · Journal of Chronic Diseases · doi:10.1016/0021-9681(77)90037-6 · Cited by 89
Treatment of Prostatic Carcinoma with Various Types of Estrogen Derivatives
Jönsson, G., Olsson, A. M., Luttrop, W., Čekan, Z., Purvis, K., & Diczfalusy, E. R. (1976) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60965-6 · Cited by 70
Morphine toxicity with dilated pupils.
Shelly, M. P., & Park, G. R. (1984) · BMJ · doi:10.1136/bmj.289.6451.1071-c · Cited by 20
Cited by
COMPARISON OF PROPOFOL AND MIDAZOLAM FOR SEDATION IN CRITICALLY ILL PATIENTS
Aitkenhead, A., Willatts, S., Park, G., Collins, C., Ledingham, I., Pepperman, M., David Coates, P., Bodenham, A., Smith, M., & Wallace, P. M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90770-8 · Cited by 213
Metadata
- Authors
- Osborne, R. J., Joel, S. P., & Slevin, M. L.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1986-06-14
- Volume
- 292
- Issue
- 6535
- Pages
- 1548-1549
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W2014219816
- Cited by
- 351
- References
- 5
- FWCI
- 22.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Osborne, R. J., Joel, S. P., & Slevin, M. L. (1986). Morphine intoxication in renal failure: the role of morphine-6-glucuronide. BMJ. https://doi.org/10.1136/bmj.292.6535.1548
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
