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Analgesic Effect of Morphine Glucuronides
Open accessAbstract
Pharmacological properties of morphine-3-glucuronide and morphine-6-glucuronide were studied in mice and compared with those of morphine. 1) The analgesic effect of morphine-6-glucuronide was 3 to 4 times as potent and approximately 2 times as long in duration as that of morphine when injected subcutaneously. Morphine-3-glucuronide, however, showed no analgesic effect even in a dose of 27.6mg/kg. 2) The analgesic effect of morphine-6-glucuronide was about 45 times as potent as that of morphine, when injected intracerebrally in mice, but morphine-3-glucuronide had no effect. 3) After intraperitoneal injection of morphine-6-glucuronide in rats, only conjugated morphine was detected in the brain by chromatographic examination but not free morphine. 4) Morphine-6-glucuronide was also antagonized by nalorphine though to slightly lesser degree than morphine. 5) Development of tolerance to morphine-6-glucuronide in analgesic effect was almost the same in degree as that to morphine. Cross tolerance between morphine-6-glucuronide and morphine was observed as well.
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Cited by
Morphine intoxication in renal failure: the role of morphine-6-glucuronide.
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Iyanagi, T. (2007) · International Review of Cytology · doi:10.1016/s0074-7696(06)60002-8 · Cited by 290
Opioid Guidelines in the Management of Chronic Non-Cancer Pain
Manchikanti, L. (2006) · Pain Physician · doi:10.36076/ppj.2006/9/2 · Cited by 277
The impact of opioid-induced hyperalgesia for postoperative pain
Koppert, W., & Schmelz, M. (2007) · Best Practice & Research Clinical Anaesthesiology · doi:10.1016/j.bpa.2006.12.004 · Cited by 154
Metadata
- Authors
- SHIMOMURA, K., KAMATA, O., UEKI, S., IDA, S., OGURI, K., YOSHIMURA, H., & TSUKAMOTO, H.
- Venue
- The Tohoku Journal of Experimental Medicine
- Publisher
- Tohoku University Medical Press
- Published
- 1971
- Volume
- 105
- Issue
- 1
- Pages
- 45-52
- ISSN
- 0040-8727 (ISSN-L)
- 1349-3329
- OpenAlex
- W1980844443
- Cited by
- 368
- References
- 0
- FWCI
- 3.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- SHIMOMURA, K., KAMATA, O., UEKI, S., IDA, S., OGURI, K., YOSHIMURA, H., & TSUKAMOTO, H. (1971). Analgesic Effect of Morphine Glucuronides. The Tohoku Journal of Experimental Medicine. https://doi.org/10.1620/tjem.105.45
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