The DOI matches its Crossref record.
Aluminium accumulation and immunosuppressive effect in recipients of kidney transplants.
Open accessAbstract
Aluminium that has accumulated in the body is thought to have a generalised cytotoxic effect. A prospective study of aluminium accumulation in bone-that is, subclinical aluminium toxicity--was carried out in 94 recipients of kidney allografts, who were followed up for three years. Subclinical aluminium toxicity was found in 66 patients. A significantly smaller proportion of patients with aluminium accumulation experienced a rejection episode: 30 (58%) nu 12 (86%) who received grafts from cadavers and 4 (29%) nu 10 (71%) who received grafts from living donors. On multivariate analysis only the source of the kidney and aluminium accumulation were found to influence the rejection rate. These findings suggest that aluminium accumulation has an immunosuppressive effect.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Toxic exposure to Al causes immunotoxicity leading to inhibition of lymphocyte and macrophage functions (Nordal et al., 1988; Zhu et al., 2014a).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Nordal et al., 1988
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 17
- Alfrey AC, Le Gendre GR, Kaehnv WD. The dialysis encephalopathy syndrome: possible aluminum intoxication. N Englj Med 1976;294:184-8. · DOI
- Parkinson I, Ward M, Kerr D. Dialysis encephalopathy, bone disease and anaemia: the aluminium intoxication syndrome during regular haemodialysis. J Clin Pathol 1981;34:1285-94. · DOI
- Boyce BF, Fell GS, Elder HY, et al. Hypercalcaemic osteomalacia due to aluminium toxicity. Lancet 1982;ii: 1009-13. · DOI
- Wills MR, Savory J. Aluminium poisoning: dialysis encephalopathy, osteomalacia, and anaemia. Lancet 1983;ii:29-34. · DOI
- Alfrey AC. The toxicity of the aluminium burden. Semin Nephrol 1983;3: 329-34.
- Maloney NA, Ott SM, Alfrey AC, Miller NL, Coburn JW, Sherrard DJ. Histological quantitation of aluminum in iliac bone from patients with renal failure. J Lab Clin,ed 1982;99:206-16.
- Dunstan CR, Evanis RA. Aluminum and renal bone disease in Australia. Kidnev IntfSuppl] 1986;18:65-9.
- Payne CD, ed. The GLIMf system manual. Release 3.77. Oxford: Numerical Algorithms Group, 1987.
- Ott SM, Maloney NA, Coburn JW, Alfrev AC, Sherrard DJ. The prevalence of bone aluminum deposition in renal osteodystrophy and its relation to the response to calcitriol therapy. L' Englj Med 1982;307:709-13. · DOI
- Smith AJ, Faugbre MC, Abreo K, Fanti P, Julian B, Malluche HH. Aluminium-related bone disease in mild and advanced renal failure: evidence for high prevalence and morbidity and studies on etiology and diagnosis.,AmJ Nephrol 1986;6:275-83.
- Opelz G, Dharmendra PS, Sengar DPS, Mickey MR, Terasaki PI. Effect of blood transfusions on subsequent kidney transplant. Transplant Proc 1973;5:253-9.
- Solheim BG. The role of pretransplant blood transfusions. Transplant Proc 1979;11: 138-44.
- Cats S, Terasaki III, Perdue S, Mickey MR. Effect of HLA typing and transfusions of cyclosporine-treated renal allograft recipients. N Englj Med 1984;311:675-6. · DOI
- Opelz G (for the Collaborative Transplant Study). Improved kidney graft survival in nontransfused recipients. Transplant Proc 1987;19:149-52.
- Platts MM, Owen G, Smith S. Water purification and the incidence of fractures in patients receiving home dialysis supervised by a single centre: evidence for "safe" upper limit of aluminium in water. Br Med J 1984;288:969-72. · DOI
- Hercz G, Andress DL, Nebecker HG, Shinaberger JH, Sherrard DJ, Coburn JW. Reversal of aluminum-related bone disease after substituting calcium carbonate for aluminum hydroxide. Amj Kidney Dis 1985;6:342-7.
- Hodsman AB, Sherrard DJ, Alfrey AC, et al. Bone aluminum and histomorphometric features of renal osteodystrophy. J Clin Endocrinol Metab 1982;54:539-46. · DOI
Cited by
Sorted by citations
Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
Krewski, D., Yokel, R. A., Nieboer, E., Borchelt, D., Cohen, J., Harry, J., Kacew, S., Lindsay, J., Mahfouz, A. M., & Rondeau, V. (2007) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701597766 · Cited by 998
Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395
“Toxic exposure to Al causes immunotoxicity leading to inhibition of lymphocyte and macrophage functions (Nordal et al., 1988; Zhu et al., 2014a).”
Background
Metadata
- Authors
- Nordal, K. P., Dahl, E., Albrechtsen, D., Halse, J., Leivestad, T., Tretli, S., & Flatmark, A.
- Affiliations
- Oslo University Hospital (NO)
- ORCID
- Tretli, S.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1988-12-17
- Volume
- 297
- Issue
- 6663
- Pages
- 1581-1582
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC1835306
- OpenAlex
- W2046423168
- Cited by
- 21
- References
- 0
- Citations by year
- 2019: 1 · 2014: 1
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
- Locations
- BMJ (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- aluminum accumulation, kidney transplantation, graft rejection, immunosuppression, deceased donor, living donor, cytotoxicity
- MeSH terms
- Adult, Aluminum, Bone and Bones, Cadaver, Graft Survival, Humans, Immunosuppression Therapy, Prospective Studies, Tissue Donors, Kidney Transplantation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
