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Oestrogen Replacement Therapy for Prevention of Osteoporosis after Oophorectomy
Open accessAbstract
The value of oestrogen therapy in the prevention of osteoporosis after oophorectomy was assessed in 114 middle-aged women who participated in a double-blind controlled trial of mestranol in an average daily dose of 23 μg. The skeletal response to treatment was measured by a photon absorption technique. Where treatment was started within two months of operation subsequent bone mineral loss was prevented. Treatment started three years after oophorectomy caused a highly significant increase in bone mineral content. When treatment was delayed for six years mestranol failed to prevent subsequent bone mineral loss with age. These effects occurred independently of the associated humoral changes in calcium and phosphorus homoeostasis. Mestranol in this dosage appeared to be relatively safe, but it is too early to evaluate the long-term hazards of such therapy.
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Citations
Cited by
Hormone therapy for preventing cardiovascular disease in post-menopausal women
Boardman, H. M., Hartley, L., Eisinga, A., Main, C., Roqué i Figuls, M., Bonfill Cosp, X., Gabriel Sanchez, R., & Knight, B. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002229.pub4 · Cited by 612
HUTCHINSON, T. (1979) · The Lancet · doi:10.1016/s0140-6736(79)90640-8 · Cited by 452
Bone mineral density after resumption of menses in amenorrheic athletes
Drinkwater, B. L. (1986) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1986.03380030082032 · Cited by 386
BONE RESPONSE TO TERMINATION OF ŒSTROGEN TREATMENT
Lindsay, R., Maclean, A., Kraszewski, A., Hart, D. M., Clark, A. C., & Garwood, J. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92402-9 · Cited by 324
Self-citationIncreased fracture frequency in adult patients with hypopituitarism and GH deficiency
Rosen, T., Wilhelmsen, L., Landin-Wilhelmsen, K., Lappas, G., & Bengtsson, B. (1997) · European Journal of Endocrinology · doi:10.1530/eje.0.1370240 · Cited by 277
Metadata
- Authors
- Aitken, J. M., Hart, D. M., & Lindsay, R.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1973-09-08
- Volume
- 3
- Issue
- 5879
- Pages
- 515-518
- ISSN
- 0007-1447 (ISSN-L)
- 1468-5833
- OpenAlex
- W2074581657
- Cited by
- 259
- References
- 0
- FWCI
- 15.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Aitken, J. M., Hart, D. M., & Lindsay, R. (1973). Oestrogen Replacement Therapy for Prevention of Osteoporosis after Oophorectomy. BMJ. https://doi.org/10.1136/bmj.3.5879.515
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
