Increased fracture frequency in adult patients with hypopituitarism and GH deficiency
Abstract
Fracture frequency was studied in 107 hypopituitary patients with GH deficiency (GHD) (69 men, mean age 53 years, range 18-74 and 38 women, mean age 54 years, range 31-73). Routine hormonal replacement therapy was given, except GH. Five male patients and 15 female patients with untreated hypogonadism were allocated to a separate group. The mean duration of hypopituitarism was 13.4 years. The prevalence of a history of fractures was assessed using questionnaires. A subsample of the Goteborg WHO MONICA Project was used as a reference population (n = 323). The total fracture frequency was threefold higher (P < 0.001) in patients (24.1%) compared with controls (8.7%) (odds ratio 3.49) (1.85-6.56; 95% confidence intervals). In men (n = 64) the fracture frequency was 25.0%, compared with 7.8% among the controls (P < 0.001). In women (n = 23) the fracture frequency was 21.7%, compared with 9.5% among the controls (P = 0.08). The odds ratios for fracture frequency were 3.97 (1.81-8.40; 95% confidence intervals) and 2.64 (0.89-7.81; 95% confidence intervals) in men and women respectively. In conclusion, adult hypopituitary patients with GHD had a threefold increased fracture frequency compared with controls. Further studies are needed to ascertain whether long-term recombinant human GH treatment can reduce the fracture rate in hypopituitary patients with GHD.
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GHD and hypopituitarism are associated with increased fracture risk.
“It has been reported that GHD and hypopituitarism are associated with increased fracture risk [17, 44, 51, 55].”
From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [55]
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Pituitary Disorders and Osteoporosis
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- Authors
- Rosen, T., Wilhelmsen, L., Landin-Wilhelmsen, K., Lappas, G., & Bengtsson, B.
- Affiliations
- Sahlgrenska University Hospital (SE)
- Venue
- European Journal of Endocrinology
- Publisher
- Oxford University Press (OUP)
- Published
- 1997-09-01
- Volume
- 137
- Issue
- 3
- Pages
- 240-245
- ISSN
- 0804-4643 (ISSN-L)
- 1479-683X
- OpenAlex
- W2142503581
- Cited by
- 277
- References
- 1
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 8 · 2019: 3 · 2018: 9 · 2017: 6 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 6 · 2012: 9
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- hypopituitarism, growth hormone deficiency, fracture incidence, osteoporosis, bone fragility, sex differences, recombinant human growth hormone therapy, hypogonadism
- MeSH terms
- Adolescent, Adult, Aged, Female, Humans, Hypopituitarism, Insulin-Like Growth Factor I, Male, Middle Aged, Sex Characteristics, Thyroxine, Odds Ratio, Human Growth Hormone, Fractures, Bone
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