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Fetal nuchal translucency: ultrasound screening for chromosomal defects in first trimester of pregnancy.
Open accessAbstract
OBJECTIVE: To examine the significance of fetal nuchal translucency at 10-14 weeks' gestation in the prediction of abnormal fetal karyotype. DESIGN: Prospective screening study. SETTING: The Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London. SUBJECTS: 827 fetuses undergoing first trimester karyotyping by amniocentesis or chorionic villus sampling. MAIN OUTCOME MEASURE: Incidence of chromosomal defects. RESULTS: The incidence of chromosomal defects was 3% (28 of 827 cases). In the 51 (6%) fetuses with nuchal translucency 3-8 mm thick the incidence of chromosomal defects was 35% (18 cases). In contrast, only 10 of the remaining 776 (1%) fetuses were chromosomally abnormal. CONCLUSION: Fetal nuchal translucency > or = 3 mm is a useful first trimester marker for fetal chromosomal abnormalities.
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Citations
Cited by
Snijders, R., Noble, P., Sebire, N., Souka, A., & Nicolaides, K. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11280-6 · Cited by 1,572
Donofrio, M. T., Moon-Grady, A. J., Hornberger, L. K., Copel, J. A., Sklansky, M. S., Abuhamad, A., Cuneo, B. F., Huhta, J. C., Jonas, R. A., Krishnan, A., et al. (2014) · Circulation · doi:10.1161/01.cir.0000437597.44550.5d · Cited by 1,275
Nuchal translucency and other first-trimester sonographic markers of chromosomal abnormalities
Nicolaides, K. H. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.03.090 · Cited by 626
Self-citationISUOG Practice Guidelines: performance of first‐trimester fetal ultrasound scan
(2013) · Ultrasound in Obstetrics & Gynecology · doi:10.1002/uog.12342 · Cited by 621
Souka, A. P., Krampl, E., Bakalis, S., Heath, V., & Nicolaides, K. H. (2001) · Ultrasound in Obstetrics & Gynecology · doi:10.1046/j.1469-0705.2001.00454.x · Cited by 369
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Metadata
- Authors
- Nicolaides, K. H., Azar, G., Byrne, D., Mansur, C., & Marks, K.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1992-04-04
- Volume
- 304
- Issue
- 6831
- Pages
- 867-869
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W1964591473
- Cited by
- 1,056
- References
- 0
- FWCI
- 21.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nicolaides, K. H., Azar, G., Byrne, D., Mansur, C., & Marks, K. (1992). Fetal nuchal translucency: ultrasound screening for chromosomal defects in first trimester of pregnancy. BMJ. https://doi.org/10.1136/bmj.304.6831.867
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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