CoChat
Sign Up
Cited by 265Bacterial Infections and VaccinesBacterial Identification and Susceptibility TestingStreptococcal Infections and Treatments

The DOI matches its Crossref record, with a small difference in title or year; 39 of the 40 references it cites were found in a registry or an index.

Early treatment with parenteral penicillin in meningococcal disease.

Open access
Cartwright, K., Reilly, S., White, D., Stuart, J.·1992·BMJ
DOI 10.1136/bmj.305.6846.143PMC PMC1883180
Open this paper in CoChat — free accountOpen PDF

Abstract

OBJECTIVE: To measure the effect of parenteral antibiotics given before admission to hospital on mortality and on bacteriological investigations in meningococcal disease. DESIGN: Retrospective review of hospital notes and laboratory and public health medicine department records. SETTING: Three health districts in south west England. SUBJECTS: Patients with meningococcal disease in Gloucester district presenting between 1 January 1982 and 31 December 1991 (n = 190); patients with meningococcal disease in Plymouth (n = 118) and Bath (n = 73) districts presenting between 1 January 1988 and 31 December 1991 (total = 381). MAIN OUTCOME MEASURE: Number of deaths from meningococcal disease. RESULTS: Parenteral antibiotic given by general practitioners was associated with a substantial reduction in mortality (from 9% to 5%; relative risk 0.6, 95% confidence interval 0.2 to 1.5); patients with a rash were more likely to be given parenteral antibiotics, and mortality was further reduced (from 12% to 5%; 0.5, 0.2 to 1.4). In a district where such treatment was regularly encouraged its use increased from 5% to 40% of cases over 10 years (p = 0.00001). Treatment with parenteral antibiotics before admission made isolation of meningococci from blood and cerebrospinal fluid less likely but did not affect nasopharyngeal cultures. CONCLUSIONS: General practitioners should carry benzylpenicillin in their emergency bags at all times and should administer it promptly, preferably intravenously, whenever meningococcal disease is suspected, unless the patient has had an anaphylactic reaction to penicillin. Specimens for culture should include a nasopharyngeal swab.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1136/bmj.305.6846.143

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 4

  1. Harvey IM, Palmer SR, Peters TJ. Meningitis: can we trust the statistics? Health Trends 1989;21:73-6.
  2. Hyg (Camb) 1984;93:167-80.
  3. Banks HS. Meningococosis. A protean disease. Lancet 1948;ii:635-40, 677-81.
  4. Department of Health and Social Security. Meningococcal infection: meningitis and septicaemia. London: DHSS, 1988. (PL/CMO(88)2.) 19 Drugs for the doctor's bag 1989. Drug Ther Bull 1989;27:17-9.

Cited by

Sorted by citations

See all 265

Related

See all

Metadata

Authors
Cartwright, K., Reilly, S., White, D., & Stuart, J.
Affiliations
Gloucestershire Royal Hospital (GB)
ORCID
Reilly, S.
Venue
BMJ
Publisher
BMJ
Published
1992-07-18
Volume
305
Issue
6846
Pages
143-147
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
DOI
10.1136/bmj.305.6846.143
PMC
PMC1883180
OpenAlex
W2049273725
Cited by
265
References
40
Citations by year
2026: 1 · 2025: 1 · 2023: 2 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 6 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 5
FWCI
9.12
Type
journal article
Language
en
Open access
Locations
  • BMJ (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Health Sciences › Medicine › Microbiology (medical) › Bacterial Identification and Susceptibility Testing
  • Health Sciences › Medicine › Infectious Diseases › Streptococcal Infections and Treatments
Keywords
meningococcal disease, penicillin G, mortality, general practitioners, nasopharyngeal culture, cerebrospinal fluid culture, rash
MeSH terms
Humans, Infusions, Parenteral, Meningitis, Meningococcal, Meningococcal Infections, Nasopharynx, Neisseria meningitidis, Patient Admission, Penicillin G, Prognosis, Time Factors, Treatment Outcome, Sepsis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review