The DOI matches its Crossref record, with a small difference in title or year; 39 of the 40 references it cites were found in a registry or an index.
Early treatment with parenteral penicillin in meningococcal disease.
Open accessAbstract
OBJECTIVE: To measure the effect of parenteral antibiotics given before admission to hospital on mortality and on bacteriological investigations in meningococcal disease. DESIGN: Retrospective review of hospital notes and laboratory and public health medicine department records. SETTING: Three health districts in south west England. SUBJECTS: Patients with meningococcal disease in Gloucester district presenting between 1 January 1982 and 31 December 1991 (n = 190); patients with meningococcal disease in Plymouth (n = 118) and Bath (n = 73) districts presenting between 1 January 1988 and 31 December 1991 (total = 381). MAIN OUTCOME MEASURE: Number of deaths from meningococcal disease. RESULTS: Parenteral antibiotic given by general practitioners was associated with a substantial reduction in mortality (from 9% to 5%; relative risk 0.6, 95% confidence interval 0.2 to 1.5); patients with a rash were more likely to be given parenteral antibiotics, and mortality was further reduced (from 12% to 5%; 0.5, 0.2 to 1.4). In a district where such treatment was regularly encouraged its use increased from 5% to 40% of cases over 10 years (p = 0.00001). Treatment with parenteral antibiotics before admission made isolation of meningococci from blood and cerebrospinal fluid less likely but did not affect nasopharyngeal cultures. CONCLUSIONS: General practitioners should carry benzylpenicillin in their emergency bags at all times and should administer it promptly, preferably intravenously, whenever meningococcal disease is suspected, unless the patient has had an anaphylactic reaction to penicillin. Specimens for culture should include a nasopharyngeal swab.
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“This leads to delays, which can have significant clinical consequences if therapy is delayed or incorrectly administered (9–11).”
From Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens (2016) · cites this paper as [11]
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Epidemic meningitis, meningococcaemia, and Neisseria meningitidis
Stephens, D. S., Greenwood, B., & Brandtzaeg, P. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61016-2 · Cited by 978
Leber, A. L., Everhart, K., Balada-Llasat, J.-M., Cullison, J., Daly, J., Holt, S., Lephart, P., Salimnia, H., Schreckenberger, P. C., DesJarlais, S., et al. (2016) · Journal of Clinical Microbiology · doi:10.1128/jcm.00730-16 · Cited by 609
Update on Meningococcal Disease with Emphasis on Pathogenesis and Clinical Management
van Deuren, M., Brandtzaeg, P., & van der Meer, J. W. M. (2000) · Clinical Microbiology Reviews · doi:10.1128/cmr.13.1.144-166.2000 · Cited by 592
Proulx, N., Frechette, D., Toye, B., Chan, J., & Kravcik, S. (2005) · QJM · doi:10.1093/qjmed/hci047 · Cited by 454
Nguyen, H. B., Rivers, E. P., Abrahamian, F. M., Moran, G. J., Abraham, E. H., Trzeciak, S. W., Huang, D. T., Osborn, T. M., Stevens, D. L., & Talan, D. A. (2006) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2006.02.015 · Cited by 359
Metadata
- Authors
- Cartwright, K., Reilly, S., White, D., & Stuart, J.
- Affiliations
- Gloucestershire Royal Hospital (GB)
- ORCID
- Reilly, S.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1992-07-18
- Volume
- 305
- Issue
- 6846
- Pages
- 143-147
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC1883180
- OpenAlex
- W2049273725
- Cited by
- 265
- References
- 40
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 6 · 2015: 2 · 2014: 5 · 2013: 2 · 2012: 5
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Health Sciences › Medicine › Microbiology (medical) › Bacterial Identification and Susceptibility Testing
- Health Sciences › Medicine › Infectious Diseases › Streptococcal Infections and Treatments
- Keywords
- meningococcal disease, penicillin G, mortality, general practitioners, nasopharyngeal culture, cerebrospinal fluid culture, rash
- MeSH terms
- Humans, Infusions, Parenteral, Meningitis, Meningococcal, Meningococcal Infections, Nasopharynx, Neisseria meningitidis, Patient Admission, Penicillin G, Prognosis, Time Factors, Treatment Outcome, Sepsis
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