The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
When to stop a clinical trial.
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When to
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“However, these decisions are rarely straightforward, and there is a different threshold for stopping a trial in the case of potential harm than in the case of benefit [17].”
From The recording of adverse events from psychological treatments in clinical trials: evidence from a review of NIHR-funded trials (2014) · cites this paper as [17]
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Citations
Cites
A Multiple Testing Procedure for Clinical Trials
O'Brien, P. C., & Fleming, T. R. (1979) · Biometrics · doi:10.2307/2530245 · Cited by 3,311
Equipoise and the Ethics of Clinical Research
Freedman, B. (1987) · New England Journal of Medicine · doi:10.1056/nejm198707163170304 · Cited by 2,339
Discrete sequential boundaries for clinical trials
GORDON LAN, K. K., & DEMETS, D. L. (1983) · Biometrika · doi:10.1093/biomet/70.3.659 · Cited by 2,310
Peto, R., Pike, M. C., Armitage, P., Breslow, N. E., Cox, D. R., Howard, S. V., Mantel, N., McPherson, K., Peto, J., & Smith, P. G. (1976) · British Journal of Cancer · doi:10.1038/bjc.1976.220 · Cited by 2,294
Zidovudine in Asymptomatic Human Immunodeficiency Virus Infection
Volberding, P. A., Lagakos, S. W., Koch, M. A., Pettinelli, C., Myers, M. W., Booth, D. K., Balfour, H. H., Reichman, R. C., Bartlett, J. A., Hirsch, M., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199004053221401 · Cited by 1,285
Dillman, R. O., Seagren, S. L., PROPERT, K. J., Guerra, J., Eaton, W. L., Perry, M. C., Carey, R. W., Frei, E., & Green, M. R. (1990) · New England Journal of Medicine · doi:10.1056/nejm199010043231403 · Cited by 1,151
Yusuf, S., Collins, R., Peto, R., Furberg, C. D., Stampfer, M. J., Goldhaber, S. Z., & Hennekens, C. H. (1985) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a061905 · Cited by 568
Preliminary Report: Findings from the Aspirin Component of the Ongoing Physicians' Health Study
The Steering Committee of the Physicians' Health Study Research Group (1988) · New England Journal of Medicine · doi:10.1056/nejm198801283180431 · Cited by 522
O’Rourke, P. P., Crone, R. K., Vacanti, J. P., Ware, J. H., Lillehei, C. W., Parad, R. B., & Epstein, M. F. (1989) · PEDIATRICS · doi:10.1542/peds.84.6.957 · Cited by 493
Designs for group sequential tests
Fleming, T. R., Harrington, D. P., & O’Brien, P. C. (1984) · Controlled Clinical Trials · doi:10.1016/s0197-2456(84)80014-8 · Cited by 354
Research works printed but not linked: 11
- Freedman B. Equilx)ise and the ethics otf clinical rcscarch. N l.ngl J Med 1987;317:141-5.
- Fleming rR, Harrington DP, O'Brien PaC. D)esigns for grouLp scqtuential tests. Controlled Clin 7rials 1984;5:348-61.
- West of Scotland Coronary Plrevention Study (iroup. A coronary primary prevention stuvtvof 6000 Scottish men aged 45-64 ycars: studydcesign.7Clin Epidemiol (in press).
- Souhami RL, Spiro SG, CLillen M. Chcmrothcrapv antd radiatioii thcralpy as compared with radiation therapy in stage III noni-snmall cc1l luIg calnccr. N Enmg1.ied 1991;324:1136.
- Ilropert KI, D)illman RO, Seagrcen SL. Chemotherapy anid radiation therapy as comparcd with radiation therapy in stage IIIll ioi-sntall ccll luilg calnccr. NlEniV/M,cd 1991;324:1 136-7. 19 1Pocock Sj, Hughes Nil). P'ractical problems in intcrim analyses, with particuilar regard to estimation. Controlled Clinl lurials 1989;10:2209-15.
- Cardiac Arrhythmia Stippression 'T'rial Investigators. Preliminary report: efiect of encainide atid flccainide oii mortality in a randimized trial of arrhythmia suppressioti after mnocardial infarction. N Etigl J Mted 1989;321:406-12.
- Pocock SJ, Hughes MD. Estimation issues in cliical trials atid overviews. StatAed 1990;9:657-7 1.
- Errington RD, Ashbv D, Gore SM, Abrams KR, Mivint S, Boiinett DE, et al. High energ) neutron treatment for pelvic cancers: study stopped becatise of incrcased mortality. RMJ 1991;302:10145-51.
- Lan KK, Simon R, Halperin M. Stochastically curtailed sampling in longterm clinical trials. Communicatiots In Statistics-Theory and Methods 1984;13:2339-53.
- ISIS Steering Committee. Intrasenous streptokinase given within 0-4 hours of onset of myocardial infarctiots rcduced mortality in ISIS-2. Lancet 1987;i:502.
- Steering Committee of the Physicians' Health Study Research Group. Final report on the aspirin component of the ongoing physicians' health study. N Englj3Med 1989;321:129-35.
Cited by
Sorted by citations
Moher, D., Hopewell, S., Schulz, K. F., Montori, V., Gotzsche, P. C., Devereaux, P. J., Elbourne, D., Egger, M., & Altman, D. G. (2010) · BMJ · doi:10.1136/bmj.c869 · Cited by 8,883
“Several group sequential statistical methods are available to adjust for multiple analyses,[129-131] and their use should be pre-specified in the trial protocol.”
MethodSPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials
Chan, A.-W., Tetzlaff, J. M., Gotzsche, P. C., Altman, D. G., Mann, H., Berlin, J. A., Dickersin, K., Hrobjartsson, A., Schulz, K. F., Parulekar, W. R., et al. (2013) · BMJ · doi:10.1136/bmj.e7586 · Cited by 6,251
The Revised CONSORT Statement for Reporting Randomized Trials: Explanation and Elaboration
Altman, D. G., Schulz, K. F., Moher, D., Egger, M., Davidoff, F., Elbourne, D., Gøtzsche, P. C., Lang, T., & for the CONSORT Group (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-8-200104170-00012 · Cited by 3,835
Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.
Amato, M. B. P., Barbas, C. S. V., Medeiros, D. M., Magaldi, R. B., Schettino, G. P., Lorenzi-Filho, G., Kairalla, R. A., Deheinzelin, D., Munoz, C., Oliveira, R., et al. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802053380602 · Cited by 3,654
Improving the Quality of Reporting of Randomized Controlled Trials: The CONSORT Statement
Begg, C. (1996) · JAMA · doi:10.1001/jama.1996.03540080059030 · Cited by 3,127
Metadata
- Authors
- Pocock, S. J.
- Affiliations
- London School of Hygiene & Tropical Medicine (GB)
- Corresponding author
- Pocock, S. J.
- ORCID
- Pocock, S. J.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1992-07-25
- Volume
- 305
- Issue
- 6847
- Pages
- 235-240
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC1882707
- OpenAlex
- W1968817382
- Cited by
- 255
- References
- 21
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 5 · 2020: 3 · 2019: 10 · 2018: 4 · 2017: 6 · 2016: 12 · 2015: 10 · 2014: 20 · 2013: 8 · 2012: 12
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- DigitalGeorgetown (Georgetown University Library) (submittedVersion)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
- Keywords
- clinical trial termination, stopping rules, trial ethics
- MeSH terms
- Clinical Trials as Topic, Data Interpretation, Statistical, Decision Making, Ethics, Medical, Risk Assessment, Information Dissemination, Editorial Policies, Uncertainty, Therapeutic Human Experimentation
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