The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Skin test reactivity and number of siblings
Open accessAbstract
Objective : To investigate the relation between skin test reactivity in children and number of siblings. Design : Cross sectional survey among school-children aged 9-11 years. Skin prick tests in the children and self completion of written questionnaire by their parents. Subjects : 5030 children in Munich and 2623 children in Leipzig and Halle, Germany. Main outcome measures : Atopic status assessed by skin prick tests. Results : After possible confounders were controlled for, the prevalence of atopic sensitisation decreased linearly with increasing number of siblings (odds ratio=0.96 for one sibling, 0.67 for five or more siblings; P=0.005). In atopic children the severity of the skin test reaction as assessed by the weal size was not associated with the number of siblings. Conclusions : Factors directly or indirectly related to the number of siblings may decrease the susceptibility of children to become atopic. Thus, declining family size may in part contribute to the increased prevalence of atopic diseases reported in Western countries over the past few decades.
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Citations
Cites
Hay fever, hygiene, and household size.
Strachan, D. P. (1989) · BMJ · doi:10.1136/bmj.299.6710.1259 · Cited by 5,054
Cited by
The Inverse Association Between Tuberculin Responses and Atopic Disorder
Shirakawa, T., Enomoto, T., Shimazu, S.-I., & Hopkin, J. M. (1997) · Science · doi:10.1126/science.275.5296.77 · Cited by 1,287
Allergy development and the intestinal microflora during the first year of life
Björkstén, B., Sepp, E., Julge, K., Voor, T., & Mikelsaar, M. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.118130 · Cited by 1,203
Family size, infection and atopy: the first decade of the 'hygiene hypothesis'
Strachan, D. (2000) · Thorax · doi:10.1136/thorax.55.suppl_1.s2 · Cited by 1,183
Reduced risk of hay fever and asthma among children of farmers
Ehrenstein, V., Mutius, V., Illi, Baumann, Böhm, & Kries, V. (2000) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2000.00801.x · Cited by 718
Gender differences in airway behaviour over the human life span
Becklake, M. R., & Kauffmann, F. (1999) · Thorax · doi:10.1136/thx.54.12.1119 · Cited by 698
Metadata
- Authors
- von Mutius, E., Martinez, F. D., Fritzsch, C., Nicolai, T., Reitmeir, P., & Thiemann, H.-H.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1994-03-12
- Volume
- 308
- Issue
- 6930
- Pages
- 692-695
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W2051812762
- Cited by
- 482
- References
- 1
- FWCI
- 8.86
- Type
- journal article
- Language
- en
- Open access
- green
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- von Mutius, E., Martinez, F. D., Fritzsch, C., Nicolai, T., Reitmeir, P., & Thiemann, H.-H. (1994). Skin test reactivity and number of siblings. BMJ. https://doi.org/10.1136/bmj.308.6930.692
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
