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Science, medicine, and the future: Pharmacogenetics
Open accessAbstract
Individual variation in response to drugs is a substantial clinical problem. Such variation ranges from failure to respond to a drug to adverse drug reactions and drug-drug interactions when several drugs are taken concomitantly. The clinical consequences range from patient discomfort through serious clinical illness to the occasional fatality. One UK study has suggested that about 1 in 15 hospital admissions are due to adverse drug reactions,1 and a recent US study estimated that 106 000 patients die and 2.2 million are injured each year by adverse reactions to prescribed drugs.2
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Citations
Cited by
Moffitt, T. E. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.4.533 · Cited by 787
Molecular genetics of CYP2D6: Clinical relevance with focus on psychotropic drugs
Bertilsson, L., Dahl, M., Dalén, P., & Al‐Shurbaji, A. (2002) · British Journal of Clinical Pharmacology · doi:10.1046/j.0306-5251.2001.01548.x · Cited by 579
Gene-Environment Interplay in Relation to Emotional and Behavioral Disturbance
Rutter, M., & Silberg, J. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135223 · Cited by 459
Pharmacogenetics, Drug-Metabolizing Enzymes, and Clinical Practice
Gardiner, S. J., & Begg, E. J. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.6 · Cited by 406
Nature, nurture, and development: from evangelism through science toward policy and practice
Rutter, M. (2002) · Child Development · doi:10.1111/1467-8624.00388 · Cited by 309
Metadata
- Authors
- Wolf, C. R.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2000-04-08
- Volume
- 320
- Issue
- 7240
- Pages
- 987-990
- ISSN
- 0959-8138 (ISSN-L)
- OpenAlex
- W2096599198
- Cited by
- 288
- References
- 0
- FWCI
- 21.48
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.