Cited by 1,075Workplace Health and Well-beingCardiac Health and Mental HealthStress Responses and Cortisol

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Chronic stress at work and the metabolic syndrome: prospective study

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Chandola, Tarani, Brunner, Eric, Marmot, Michael·2006·BMJ

DOI 10.1136/bmj.38693.435301.80PMC PMC1388129

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Abstract

OBJECTIVES: To investigate the association between stress at work and the metabolic syndrome. [table: see text]. DESIGN: Prospective cohort study investigating the association between work stress and the metabolic syndrome. PARTICIPANTS: 10 308 men and women, aged 35-55, employed in 20 London civil service departments at baseline (the Whitehall II study); follow-up was an average of 14 years. MAIN OUTCOME MEASURES: Work stress based on the iso-strain model, measured on four occasions (1985-99). Biological measures of the metabolic syndrome, based on the National Cholesterol Education Program definition, measured in 1997-9. RESULTS: A dose-response relation was found between exposure to work stressors over 14 years and risk of the metabolic syndrome, independent of other relevant risk factors. Employees with chronic work stress (three or more exposures) were more than twice as likely to have the syndrome than those without work stress (odds ratio adjusted for age and employment grade 2.25, 95% confidence interval 1.31 to 3.85). CONCLUSIONS: Stress at work is an important risk factor for the metabolic syndrome. The study provides evidence for the biological plausibility of the link between psychosocial stressors from everyday life and heart disease.

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Authors: Chandola, T., Brunner, E., & Marmot, M.
Affiliations: University College London (GB)
Corresponding author: Chandola, Tarani
ORCID: Chandola, Tarani
Brunner, Eric
Marmot, Michael
Venue: BMJ
Publisher: BMJ
Published: 2006-01-20
Volume: 332
Issue: 7540
Pages: 521-525
ISSN: 0007-1447 (ISSN-L)
0959-8138
1468-5833
DOI: 10.1136/bmj.38693.435301.80
PMC: PMC1388129
OpenAlex: W2140275529
Cited by: 1,075
References: 26
Citations by year: 2026: 32 · 2025: 26 · 2024: 33 · 2023: 36 · 2022: 54 · 2021: 38 · 2020: 63 · 2019: 63 · 2018: 68 · 2017: 59 · 2016: 63 · 2015: 55 · 2014: 78 · 2013: 69 · 2012: 53
FWCI: 110.80
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.bmj.org/licenses/tdm/1.0/terms-and-conditions.html (tdm)
Locations: BMJ (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Funders: John D. and Catherine T. MacArthur Foundation (HS06516)
British Heart Foundation (HS06516)
Health and Safety Executive
National Institutes of Health
Agency for Healthcare Research and Quality (HS06516)
Medical Research Council (HS06516)
Economic and Social Research Council
National Institute on Aging (AG 13196)
National Heart, Lung, and Blood Institute (HL36310, R01HL036310)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Workplace Health and Well-being
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: chronic occupational stress, metabolic syndrome, psychosocial stressors, dose-response relationship, cardiovascular risk factors, heart disease, civil service employees, Whitehall II study
MeSH terms: Adult, Chronic Disease, Female, Follow-Up Studies, Heart Diseases, Humans, Male, Middle Aged, Occupational Diseases, Prospective Studies, Stress, Psychological, Cohort Studies, Metabolic Syndrome

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Chronic stress at work and the metabolic syndrome: prospective study

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