Non-degenerative mild cognitive impairment in elderly people and use of anticholinergic drugs: longitudinal cohort study
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Background: Little information is available in Canada about the prevalence of and outcomes associated with a history of slapping and spanking in childhood. The objectives of this study were to estimate the prevalence of a history of slapping or spanking in a general population sample and to assess the relation between such a history and the lifetime prevalence of psychiatric disorders. Methods: In this general population survey, a probability sample of 9953 residents of Ontario aged 15 years and older who participated in the Ontario Health Supplement was used to examine the prevalence of a history of slapping and spanking. A subgroup of this sample (n = 4888), which comprised people aged 15 to 64 years who did not report a history of physical or sexual abuse during childhood, was used to assess the relation between a history of slapping or spanking and the lifetime prevalence of 4 categories of psychiatric disorder. The measures included a self-administered questionnaire with a question about frequency of slapping and spanking during childhood, as well as an interviewer-administered questionnaire to measure psychiatric disorder. Results: The majority of respondents indicated that they had been slapped or spanked, or both, by an adult during childhood "sometimes" (33.4%) or "rarely" (40.9%); 5.5% reported that this occurred "often." The remainder (20.2%) reported "never" experiencing these behaviours. Among the respondents without a history of physical or sexual abuse during childhood, those who reported being slapped or spanked "often" or "sometimes" had significantly higher lifetime rates of anxiety disorders (adjusted odds ratio [OR] 1.43, 95% confidence interval [CI] 1.04-1.96), alcohol abuse or dependence (adjusted OR 2.02, 95% CI 1.27-3.21) and one or more externalizing problems (adjusted OR 2.08, 95% CI 1.36-3.16), compared with those who reported "never" being slapped or spanked. There was also an association between a history of slapping or spanking and major depression, but it was not statistically significant (adjusted OR 1.64, 95% CI 0.96-2.80). Interpretation: There appears to be a linear association between the frequency of slapping and spanking during childhood and a lifetime prevalence of anxiety disorder, alcohol abuse or dependence and externalizing problems.
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Several investigators have reported that anticholinergic medications may be associated with increased risk for sustained cognitive deficits such as mild cognitive impairment or dementia.
“However, several investigators have reported that anticholinergic medications may be associated with increased risk for sustained cognitive deficits such as mild cognitive impairment or dementia.1,2,14”
From Cumulative Use of Strong Anticholinergics and Incident Dementia: A Prospective Cohort Study (2015) · cites this paper as [2]
The Discussion reports that elderly anticholinergic-drug users were more likely to have mild cognitive impairment. However, the Development of dementia section reports no difference in dementia rates at eight years (16% versus 14%), so the dementia part of the claim is not supported by this paper. (LLM, conf=0.89)
Experimental — accuracy not yet measuredPrevious longitudinal cohort studies indicate that anticholinergic medications negatively affect cognitive performance.
“This association between anticholinergic antidepressants and dementia aligns with previous longitudinal cohort studies indicating that anticholinergic medications negatively affect cognitive performance [15, 31, 32, 43, 44].”
From Long-Term Antidepressant Use and Dementia Risk: A Propensity Score-Matched Study of Swiss Older Adults, with an Anticholinergic-Specific Analysis (2026) · cites this paper as [43]
Observational studies of anticholinergic drugs and dementia risk have generally been relatively small, only assessed short-term exposure, or were subject to recall bias.
“Observational studies of anticholinergic drugs and dementia risk7,8,9,10 have generally been relatively small, only assessed short-term exposure, or were subject to recall bias.”
From Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study (2019) · cites this paper as [8]
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Cumulative Use of Strong Anticholinergics and Incident Dementia: A Prospective Cohort Study
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Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study
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- Authors
- Ancelin, M. L., Artero, S., Portet, F., Dupuy, A.-M., Touchon, J., & Ritchie, K.
- Affiliations
- Inserm (FR)
- Corresponding author
- Ritchie, Karen
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2006-02-01
- Volume
- 332
- Issue
- 7539
- Pages
- 455-459
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC1382539
- OpenAlex
- W2044589919
- Cited by
- 589
- References
- 3
- Citations by year
- 2026: 15 · 2025: 13 · 2024: 25 · 2023: 21 · 2022: 21 · 2021: 33 · 2020: 42 · 2019: 39 · 2018: 27 · 2017: 30 · 2016: 30 · 2015: 40 · 2014: 29 · 2013: 20 · 2012: 25
- FWCI
- 21.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Fondation de France
- Conservatoire National des Arts et Métiers
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Keywords
- older adults, anticholinergic agents, cognitive decline, drug use
- MeSH terms
- Aged, Aged, 80 and over, Attention, Cognition Disorders, Dementia, Epidemiologic Methods, France, Humans, Language Disorders, Memory Disorders, Middle Aged, Neuropsychological Tests, Reaction Time, Space Perception, Thinking, Cholinergic Antagonists
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