The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Protective effect of antibiotics against serious complications of common respiratory tract infections: retrospective cohort study with the UK General Practice Research Database
Open accessAbstract
OBJECTIVE: To determine the extent to which antibiotics reduce the risk of serious complications after common respiratory tract infections. DESIGN: Retrospective cohort study. SETTING: UK primary care practices contributing to the general practice research database. DATA SOURCE: 3.36 million episodes of respiratory tract infection. MAIN OUTCOME MEASURES: Risk of serious complications in treated and untreated patients in the month after diagnosis: mastoiditis after otitis media, quinsy after sore throat, and pneumonia after upper respiratory tract infection and chest infection. Number of patients needed to treat to prevent one complication. RESULTS: Serious complications were rare after upper respiratory tract infections, sore throat, and otitis media, and the number needed to treat was over 4000. The risk of pneumonia after chest infection was high, particularly in elderly people, and was substantially reduced by antibiotic use, with a number needed to treat of 39 for those aged > or =65 and 96-119 in younger age groups. CONCLUSION: Antibiotics are not justified to reduce the risk of serious complications for upper respiratory tract infection, sore throat, or otitis media. Antibiotics substantially reduce the risk of pneumonia after chest infection, particularly in elderly people in whom the risk is highest.
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The Read clinical classification.
Chisholm, J. (1990) · BMJ · doi:10.1136/bmj.300.6732.1092 · Cited by 504
Cited by
Murray, E., Treweek, S., Pope, C., MacFarlane, A., Ballini, L., Dowrick, C., Finch, T., Kennedy, A., Mair, F., O'Donnell, C., et al. (2010) · BMC Medicine · doi:10.1186/1741-7015-8-63 · Cited by 1,478
Little, P., Stuart, B., Francis, N., Douglas, E., Tonkin-Crine, S., Anthierens, S., Cals, J. W., Melbye, H., Santer, M., Moore, M., et al. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60994-0 · Cited by 430
Sabuncu, E., David, J., Bernède-Bauduin, C., Pépin, S., Leroy, M., Boëlle, P.-Y., Watier, L., & Guillemot, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000084 · Cited by 406
Adriaenssens, N., Coenen, S., Tonkin-Crine, S., Verheij, T. J. M., Little, P., & Goossens, H. (2011) · BMJ Quality & Safety · doi:10.1136/bmjqs.2010.049049 · Cited by 309
Principles of Judicious Antibiotic Prescribing for Upper Respiratory Tract Infections in Pediatrics
Hersh, A. L., Jackson, M. A., Hicks, L. A., the COMMITTEE ON INFECTIOUS DISEASES, Brady, M. T., Byington, C. L., Davies, H. D., Edwards, K. M., Maldonado, Y. A., Murray, D. L., et al. (2013) · Pediatrics · doi:10.1542/peds.2013-3260 · Cited by 266
Metadata
- Authors
- Petersen, I., Johnson, A. M., Islam, A., Duckworth, G., Livermore, D. M., & Hayward, A. C.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2007-10-18
- Volume
- 335
- Issue
- 7627
- Pages
- 982
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W2049529849
- Cited by
- 304
- References
- 1
- FWCI
- 19.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Petersen, I., Johnson, A. M., Islam, A., Duckworth, G., Livermore, D. M., & Hayward, A. C. (2007). Protective effect of antibiotics against serious complications of common respiratory tract infections: retrospective cohort study with the UK General Practice Research Database. BMJ. https://doi.org/10.1136/bmj.39345.405243.be
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