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Cited by 205Rheumatoid Arthritis Research and TherapiesInflammatory mediators and NSAID effectsNatural Compounds in Disease Treatment

Clinical measurement of the anti-inflammatory effects of salicylates in rheumatoid arthritis.

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Boardman, P L, Hart, F D·1967·BMJ
DOI 10.1136/bmj.4.5574.264PMC PMC1748911
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Abstract

Salicylates in relatively low dosage modify certain components of the inflammatory reaction in animal experiments (Adams and Cobb, 1963).Theoretically they may be used in rheumatoid arthritis to promote the relief of pain or for their anti- inflammatory effect.It is important to determine whether there is a different dose-response relationship for each of these characteristics.The cardinal signs of inflammation-pain, heat, redness, and swelling-are the indices available for the direct clinical assess- ment of inflammatory activity in rheumatoid arthritis.Pain is subjective and difficult to quantitate.Joint heat was studied by Smyth and Clark (1957) and by Vaughn, Howell, and Kiem (1959); it was found to be of little value.The latter authors also found redness an unsatisfactory index for assessment.Hart and Clark (1951) introduced the method of standard jewellers' rings for the measurement of joint size, by which accurate serial recordings could be made.Fremont-Smith and Bayles (1965) investigated the effect of high dosage of salicylate in 11 patients in hospital with rheumatoid arthritis.Aspirin was given orally in increasing quantity over a five-day period until the largest tolerated dose was reached-on average, 5.2 g./24 hours.In most cases dosage increase was stopped because of tinnitus or deafness.Potent analgesics without anti-inflammatory action were then abruptly substituted.An increase in joint size, measured by standard jewellers' rings, and deterioration of grip strength, symptoms, and other indices followed rapidly the withdrawal of aspirin.They concluded that all patients with active rheumatoid arthritis, whether it was mild or severe, should receive salicylates regularly in the largest tolerated dosage in the absence of obvious contraindications.Because of side- effects "blind" techniques and quantitation of the changes were not attempted.* Westminster, Hospital London S.W.1.

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  1. [5]5. Adams, S. S., and Cobb, R. (1963). In Salicylates, An International Symposium, edited by A. St. J. Dixon, B. K. Martin, M. J. H. Smith, and P. H. N. Wood, p. 127. London. American Rheumatism Association (1959). Ann rheum. Dis., 18, 49.
  2. [6]6. Bywaters, E. G. L. (1963). In Salicylates, An International Symposium, edited by A. St. J. Dixon, B. K. Martin, M. J. H. Smith, and P. H. N. Wood, p. 154. London.
  3. [13]13. Wright, V. (1959). Clin. Sci., 18, 17. Glyceryl Trinitrate in Angina Pectoris: Tablet or Aerosol ? G SANDLER,* M.D., M.R.C.P.; G. A. CLAYTONt M.B., CH.B. Brit. med.JI., 1967, 4, 268-270

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Authors
Boardman, P. L., & Hart, F. D.
ORCID
Hart, F D
Venue
BMJ
Publisher
BMJ
Published
1967-11-04
Volume
4
Issue
5574
Pages
264-268
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
DOI
10.1136/bmj.4.5574.264
PMC
PMC1748911
OpenAlex
W1992653585
Cited by
205
References
6
Citations by year
2026: 1 · 2024: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2013: 2 · 2012: 2
FWCI
13.15
Type
journal article
Language
en
Open access
Locations
  • BMJ (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
  • Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords
salicylates, aspirin, rheumatoid arthritis, anti-inflammatory activity, dose-response relationship, joint swelling, grip strength, pain
MeSH terms
Acetaminophen, Anthropometry, Arthritis, Rheumatoid, Clinical Trials as Topic, Humans, Placebos, Prednisone, Salicylates

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