The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) Study
Open accessAbstract
OBJECTIVES: To estimate life expectancy for people with HIV undergoing treatment compared with life expectancy in the general population and to assess the impact on life expectancy of late treatment, defined as CD4 count <200 cells/mm(3) at start of antiretroviral therapy. DESIGN: Cohort study. SETTING: Outpatient HIV clinics throughout the United Kingdom. Population Adult patients from the UK Collaborative HIV Cohort (UK CHIC) Study with CD4 count ≤ 350 cells/mm(3) at start of antiretroviral therapy in 1996-2008. MAIN OUTCOME MEASURES: Life expectancy at the exact age of 20 (the average additional years that will be lived by a person after age 20), according to the cross sectional age specific mortality rates during the study period. RESULTS: 1248 of 17,661 eligible patients died during 91,203 person years' follow-up. Life expectancy (standard error) at exact age 20 increased from 30.0 (1.2) to 45.8 (1.7) years from 1996-9 to 2006-8. Life expectancy was 39.5 (0.45) for male patients and 50.2 (0.45) years for female patients compared with 57.8 and 61.6 years for men and women in the general population (1996-2006). Starting antiretroviral therapy later than guidelines suggest resulted in up to 15 years' loss of life: at age 20, life expectancy was 37.9 (1.3), 41.0 (2.2), and 53.4 (1.2) years in those starting antiretroviral therapy with CD4 count <100, 100-199, and 200-350 cells/mm(3), respectively. CONCLUSIONS: Life expectancy in people treated for HIV infection has increased by over 15 years during 1996-2008, but is still about 13 years less than that of the UK population. The higher life expectancy in women is magnified in those with HIV. Earlier diagnosis and subsequent timely treatment with antiretroviral therapy might increase life expectancy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Changing patterns of mortality across Europe in patients infected with HIV-1
Mocroft, A., Vella, S., Benfield, T., Chiesi, A., Miller, V., Gargalianos, P., Monforte, A. D., Yust, I., Bruun, J., Phillips, A. N., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)03201-2 · Cited by 1,269
Self-citationBraitstein, P. K. A. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68337-2 · Cited by 1,106
Gazzard, B., & on behalf of the BHIVA Treatment Guidelines Writing Group (2008) · HIV Medicine · doi:10.1111/j.1468-1293.2008.00636.x · Cited by 1,090
Self-citation. Survival of persons with and without HIV infection in Denmark, 1995-2005.
Lohse, N., Hansen, A.-B. E., Pedersen, G., Kronborg, G., Gerstoft, J., Sørensen, H. T., Væth, M., & Obel, N. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-146-2-200701160-00003 · Cited by 748
Egger, M., Hirschel, B. J., Francioli, P. B., Sudre, P., Wirz, M., Flepp, M., Rickenbach, M., Malinverni, R., Vernazza, P., & Battegay, M. (1997) · BMJ · doi:10.1136/bmj.315.7117.1194 · Cited by 615
Bhaskaran, K. (2008) · JAMA · doi:10.1001/jama.300.1.51 · Cited by 495
Years of Potential Life Lost (YPLL)—What Does it Measure?
Gardner, J. W., & Sanborn, J. S. (1990) · Epidemiology · doi:10.1097/00001648-199007000-00012 · Cited by 407
van Sighem, A., Gras, L. A., Reiss, P., Brinkman, K., & de Wolf, F. (2010) · AIDS · doi:10.1097/qad.0b013e32833a3946 · Cited by 397
The Antiretroviral Therapy (ART) Cohort Collaboration (2007) · AIDS · doi:10.1097/qad.0b013e328133f285 · Cited by 292
Flagged first, then by citations
1 of the 40 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Association of cardiometabolic multimorbidity with mortality
Di Angelantonio, E., Kaptoge, S., Wormser, D., Willeit, P., Butterworth, A. S., Bansal, N., O’Keeffe, L. M., Gao, P., Wood, A. M., Burgess, S., et al. (2015) · JAMA · doi:10.1001/jama.2015.7008 · Cited by 1,155
Trickey, A., May, M., Vehreschild, J. J., Obel, N., Gill, M. J., Crane, H. M., Boesecke, C., Patterson, S., Grabar, S., Cazanave, C., et al. (2017) · The Lancet HIV · doi:10.1016/s2352-3018(17)30066-8 · Cited by 1,089
Self-citationMay, M., Gompels, M. M., Delpech, V., Porter, K., Orkin, C. M., Kegg, S., Hay, P., Johnson, M. A., Palfreeman, A., Gilson, R. J. C., et al. (2014) · AIDS · doi:10.1097/qad.0000000000000243 · Cited by 621
Self-citationTrickey, A., Sabin, C. A., Burkholder, G., Crane, H. M., Monforte, A. D., Egger, M., Gill, M. J., Grabar, S., Guest, J. L., Jarrín, I., et al. (2023) · The Lancet HIV · doi:10.1016/s2352-3018(23)00028-0 · Cited by 540
Self-citationHelleberg, M., Afzal, S., Kronborg, G., Larsen, C. S., Pedersen, G., Pedersen, C., Gerstoft, J., Nordestgaard, B. G., & Obel, N. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cis933 · Cited by 463
Metadata
- Authors
- May, M., Gompels, M., Delpech, V., Porter, K., Post, F., Johnson, M., Dunn, D., Palfreeman, A., Gilson, R., Gazzard, B., Hill, T., Walsh, J., Fisher, M., Orkin, C., Ainsworth, J., Bansi, L., Phillips, A., Leen, C., Nelson, M., Anderson, J., & Sabin, C.
- Affiliations
- University of Bristol (GB)
- North Bristol NHS Trust (GB)
- University College London (GB)
- King's College London (GB)
- The Royal Free Hospital (GB)
- Medical Research Council (GB)
- Leicester Royal Infirmary (GB)
- Mortimer Market Centre (GB)
- Chelsea and Westminster Hospital (GB)
- Imperial College Healthcare NHS Trust (GB)
- Brighton and Sussex University Hospitals NHS Trust (GB)
- Queen Mary University of London (GB)
- North Middlesex Hospital (GB)
- Western General Hospital (GB)
- Homerton University Hospital (GB)
- Corresponding author
- May, M.
- ORCID
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2011-10-11
- Volume
- 343
- Issue
- oct11 2
- Pages
- d6016-d6016
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC3191202
- OpenAlex
- W2008613145
- Cited by
- 363
- References
- 40
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 11 · 2023: 21 · 2022: 21 · 2021: 18 · 2020: 21 · 2019: 22 · 2018: 26 · 2017: 16 · 2016: 42 · 2015: 39 · 2014: 31 · 2013: 34 · 2012: 30
- FWCI
- 22.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- BMJ (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Research Portal (King's College London) (publishedVersion, other-oa)
- Figshare (submittedVersion, cc-by)
- ResearchOnline (submittedVersion)
- Sussex Research Online (University of Sussex) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by-nc)
- Bristol Research (University of Bristol) (submittedVersion)
- ResearchOnline (Glasgow Caledonian University) (submittedVersion, cc-by-nc)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Infectious Diseases › HIV-related health complications and treatments
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Keywords
- HIV-1, life expectancy, delayed diagnosis, late treatment, antiretroviral therapy, CD4 count, mortality, sex differences
- MeSH terms
- Adult, Aged, Cooperative Behavior, Drug Therapy, Combination, Female, United Kingdom, Humans, Life Expectancy, Male, Middle Aged, Time Factors, Cohort Studies, HIV-1, HIV Infections, Practice Guidelines as Topic, CD4 Lymphocyte Count, Anti-HIV Agents, Young Adult, Delayed Diagnosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
