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Making inferences on treatment effects from real world data: propensity scores, confounding by indication, and other perils for the unwary in observational research
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Propensity score based methods are used increasingly to evaluate the effectiveness of treatments when evidence from randomised trials is not available. However, users need to be aware of their strengths and limitations
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“Hence, the prognosis of those receiving the (drug) treatment may be better or worse than those who are not, but information on prognosis and/or severity of the underlying illness may not be available in the data [72].”
From The Reporting of Studies Conducted Using Observational Routinely-Collected Health Data (RECORD) statement. (2015) · cites this paper as [72]
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“A particular type of unmeasured confounding is confounding by indication; this is often an issue when examining effectiveness and safety of (drug) treatments using routinely collected data.”
From The Reporting of Studies Conducted Using Observational Routinely-Collected Health Data (RECORD) statement. (2015) · cites this paper as [72]
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Reducing the Harm of Medication - Recent Trends in Pharmacovigilance, Volume II
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Self-citationSafety of sodium-glucose cotransporter-2 inhibitors for heart failure
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Metadata
- Authors
- Freemantle, N., Marston, L., Walters, K., Wood, J., Reynolds, M. R., & Petersen, I.
- Affiliations
- The Royal Free Hospital (GB)
- Lahey Hospital and Medical Center (US)
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2013-11-11
- Volume
- 347
- Issue
- nov11 3
- Pages
- f6409-f6409
- ISSN
- 1756-1833 (ISSN-L)
- OpenAlex
- W1989803330
- Cited by
- 211
- References
- 20
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 7 · 2023: 18 · 2022: 23 · 2021: 14 · 2020: 26 · 2019: 15 · 2018: 28 · 2017: 22 · 2016: 23 · 2015: 15 · 2014: 5
- FWCI
- 12.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Epidemiology
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Keywords
- propensity score, confounding by indication, real-world data, observational studies, treatment effect estimation, causal inference, effectiveness evaluation
- MeSH terms
- Humans, Research, Research Design, Reproducibility of Results, Bias, Confounding Factors, Epidemiologic, Randomized Controlled Trials as Topic, Treatment Outcome, Propensity Score, Observational Studies as Topic
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