Neonatal sepsis in South Asia: huge burden and spiralling antimicrobial resistance
Open accessAbstract
M Jeeva Sankar and colleagues call for urgent action to improve quality of care at birth and implement antimicrobial stewardship in health facilities in South Asia to reduce neonatal deaths from sepsis
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Various commercially available antimicrobial drugs exhibit prominent defects, including nonspecific targeting and low concentrations in the lesion, leading to low efficiency, high toxicity, various side effects and multidrug resistance.
“At present, various commercially available antimicrobial drugs exhibit some prominent defects, including nonspecific targeting and low concentrations in the lesion, which leads to low efficiency, high toxicity, various side effects15 and multidrug resistance.16,17”
From Identification of heptapeptides targeting a lethal bacterial strain in septic mice through an integrative approach (2022) · cites this paper as [16]
The ‘Spiralling antimicrobial resistance’ section (Table 2; page unavailable) reports substantial multidrug resistance among pathogens isolated from babies with neonatal sepsis in South Asian hospitals. It does not attribute that resistance to nonspecific drug targeting or low concentrations at lesions, nor does it establish those defects for commercially available antimicrobials generally. The adjacent side-effects claim is cited separately in the citing sentence. (LLM, conf=0.86)
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Cites
Naghavi, M., Abajobir, A. A., Abbafati, C., Abbas, K. M., Abd-Allah, F., Abera, S. F., Aboyans, V., Adetokunboh, O., Afshin, A., Agrawal, A., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(17)32152-9 · Cited by 4,821 · see citing works
Llor, C., & Bjerrum, L. (2014) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098614554919 · Cited by 2,079 · see citing works
Bhutta, Z. A., Das, J. K., Bahl, R., Lawn, J. E., Salam, R. A., Paul, V. K., Sankar, M. J., Blencowe, H., Rizvi, A., Chou, V. B., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60792-3 · Cited by 1,367 · see citing works
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- [2]Liu L Oza S Hogan D Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet 2015; 385: 430- 40. 10.1016/S0140-6736(14)61698-6. 25280870 · DOI · Paper page
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Cited by
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Carvalho, M. J., Sands, K., Thomson, K., Portal, E., Mathias, J., Milton, R., Gillespie, D., Dyer, C., Akpulu, C., Boostrom, I., et al. (2022) · Nature Microbiology · doi:10.1038/s41564-022-01184-y · Cited by 95 · see citing works
Zhang, X., Li, S., Luo, H., He, S., Yang, H., Li, L., Tian, T., Han, Q., Ye, J., Huang, C., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01035-6 · Cited by 14 · see citing works
“At present, various commercially available antimicrobial drugs exhibit some prominent defects, including nonspecific targeting and low concentrations in the lesion, which leads to low efficiency, high toxicity, various side effects(15) and multidrug resistance.(16,17) In the era of precision medicine, targeted drug de…”
Background
- Authors
- Chaurasia, S., Sivanandan, S., Agarwal, R., Ellis, S., Sharland, M., & Sankar, M. J.
- Affiliations
- All India Institute of Medical Sciences (IN)
- Drugs for Neglected Diseases Initiative (CH)
- St George's, University of London (GB)
- Corresponding author
- Sankar, M Jeeva
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2019-01-22
- Volume
- 364
- Pages
- k5314
- ISSN
- 1756-1833 (ISSN-L)
- 0959-8138
- PMC
- PMC6340339
- OpenAlex
- W2912065765
- Cited by
- 258
- References
- 3
- Citations by year
- 2026: 19 · 2025: 33 · 2024: 44 · 2023: 34 · 2022: 46 · 2021: 49 · 2020: 24 · 2019: 9
- FWCI
- 29.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- BMJ (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- St George's Online Research Archive (St George's University of London) (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
- Keywords
- neonatal sepsis, antimicrobial resistance, antimicrobial stewardship, neonatal mortality, South Asia
- MeSH terms
- Neonatal Sepsis, Antimicrobial Stewardship, Anti-Bacterial Agents, Asia, Humans, Infant, Newborn, Quality of Health Care, Incidence, Drug Resistance, Bacterial
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