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Association of ideal cardiovascular health at age 50 with incidence of dementia: 25 year follow-up of Whitehall II cohort study
Open accessAbstract
Objectives: To examine the association between the Life Simple 7 cardiovascular health score at age 50 and incidence of dementia. Design: Prospective cohort study. Setting: Civil service departments in London (Whitehall II study; study inception 1985-88). Participants: 7899 participants with data on the cardiovascular health score at age 50. Exposures: The cardiovascular health score included four behavioural (smoking, diet, physical activity, body mass index) and three biological (fasting glucose, blood cholesterol, blood pressure) metrics, coded on a three point scale (0, 1, 2). The cardiovascular health score was the sum of seven metrics (score range 0-14) and was categorised into poor (scores 0-6), intermediate (7-11), and optimal (12-14) cardiovascular health. Main outcome measure: Incident dementia, identified through linkage to hospital, mental health services, and mortality registers until 2017. Results: 347 incident cases of dementia were recorded over a median follow-up of 24.7 years. Compared with an incidence rate of dementia of 3.2 (95% confidence interval 2.5 to 4.0) per 1000 person years among the group with poor cardiovascular health, the absolute rate differences per 1000 person years were −1.5 (95% confidence interval −2.3 to −0.7) for the group with intermediate cardiovascular health and −1.9 (−2.8 to −1.1) for the group with optimal cardiovascular health. Higher cardiovascular health score was associated with a lower risk of dementia (hazard ratio 0.89 (0.85 to 0.95) per 1 point increment in the cardiovascular health score). Similar associations with dementia were observed for the behavioural and biological subscales (hazard ratios per 1 point increment in the subscores 0.87 (0.81 to 0.93) and 0.91 (0.83 to 1.00), respectively). The association between cardiovascular health at age 50 and dementia was also seen in people who remained free of cardiovascular disease over the follow-up (hazard ratio 0.89 (0.84 to 0.95) per 1 point increment in the cardiovascular health score). Conclusion: Adherence to the Life Simple 7 ideal cardiovascular health recommendations in midlife was associated with a lower risk of dementia later in life.
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“better scores on this index are associated with lower dementia risk.”
From Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission (2024) · cites this paper as [149]
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ApoE in Lipidomic Signature of Alzheimer’s Disease
Wartchow, K. M., Souza, D. O., & McIntire, L. B. (2026) · Springer eBooks · doi:10.1007/978-3-031-52641-1_65-1
ApoE in Lipidomic Signature of Alzheimer’s Disease
Wartchow, K. M., Souza, D. O., & McIntire, L. B. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_65
Li, P., Wang, X., Tang, B., Gu, P., Chen, G., Mao, X., Xiao, T., & Li, H. (2026) · Clinical Rheumatology · doi:10.1007/s10067-026-08217-5
Güzel, E. Ç., & GÜZEL, M. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1884887
Metadata
- Authors
- Sabia, S., Fayosse, A., Dumurgier, J., Schnitzler, A., Empana, J.-P., Ebmeier, K. P., Dugravot, A., Kivimäki, M., & Singh-Manoux, A.
- Affiliations
- Inserm (FR)
- University of Oxford (GB)
- ORCID
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2019-08-07
- Volume
- 366
- Pages
- l4414
- ISSN
- 1756-1833 (ISSN-L)
- 0959-8138
- PMC
- PMC6664261
- OpenAlex
- W2966774490
- Cited by
- 205
- References
- 37
- Citations by year
- 2026: 7 · 2025: 20 · 2024: 39 · 2023: 31 · 2022: 50 · 2021: 34 · 2020: 16 · 2019: 7
- FWCI
- 21.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- BMJ (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Työväentutkimus Vuosikirja (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- British Heart Foundation (RG/16/11/32334, PG/11/63/29011, RG/13/2/30098)
- NordForsk (75021)
- Medical Research Council (MR/K013351/1, MR/S011676/1, MR/R024227/1)
- Economic and Social Research Council (ES/J023299/1)
- National Institute on Aging (R01AG034454, RF1AG062553, R01AG056477)
- National Heart, Lung, and Blood Institute (R01HL036310)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- dementia incidence, cardiovascular health score, smoking, diet, physical activity, body mass index, fasting blood glucose, serum cholesterol, blood pressure, dementia risk
- MeSH terms
- Healthy Lifestyle, Adult, Aged, Cardiovascular Diseases, Dementia, Female, Follow-Up Studies, Health Status, Humans, Longitudinal Studies, Male, Middle Aged, Prospective Studies, Risk Factors, Incidence
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