Impact of weight loss on waist circumference and the components of the metabolic syndrome
Open accessAbstract
Objective: Central adiposity is a component of the metabolic syndrome (MetS). Little is known about the impact of medical weight loss and decreased waist circumference (WC) on the MetS. Our objective was to assess the impact of changes in WC on blood pressure, lipids and glycemia. Research design and methods: We studied 430 obese patients enrolled in a 2-year, intensive, behavioral, weight management program. We report results for participants who completed 6-month and 2-year follow-up. Results: Participants were 49±9 years of age (mean±SD), 56% were women and 85% were white. Baseline body mass index (BMI) was 41±6 kg/m 2 and baseline WC was 120±14 cm. At 6 months, BMI decreased by 6±3 kg/m 2 and WC by 14±9 cm. Relative change in WC was defined as the 6-month or 2-year WC minus the baseline WC divided by the baseline WC. Systolic blood pressure decreased by 8 mm Hg for the tertile of participants with the largest relative decrease in WC and by 2 mm Hg for those with the smallest relative decrease in WC (p=0.025). Similar patterns of improvement were observed in total cholesterol (−29 vs −12 mg/dL, p=0.017), low-density lipoprotein-cholesterol (−19 vs −4 mg/dL, p=0.033), and glycated hemoglobin (−1.2 vs −0.3%, p=0.006). At 2 years, BMI decreased by 5±4 kg/m 2 and WC by 11±11 cm and similar patterns of improvements were seen in components of the MetS. At both 6 months and 2 years, larger relative decreases in WC were associated with greater improvements in lipids and glycemia independent of sex. Conclusions: In obese people, greater relative decreases in WC with medical weight loss are associated with greater improvements in components of the MetS independent of sex.
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Serially-obtained CT-measured waist circumference may also provide prognostic information in obese patients, although further validation is required.
“serially-obtained CT-measured WC may also provide prognostic information in obese patients, although further validation is required.”
From Fully automated waist circumference measurement on abdominal CT: Comparison with manual measurements and potential value for identifying overweight and obesity as an adjunct output of CT scan (2021) · cites this paper as [21]
The Conclusions (page unavailable) say that monitoring changes in waist circumference during weight-loss interventions may provide prognostic information about metabolic risk in obese patients. However, the Research design and methods section (page unavailable) says waist circumference was measured with a nylon tape, not CT; the paper does not validate the claim for CT-measured waist circumference. (LLM, conf=0.90)
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References 13 · Cited by 92
Research works printed but not linked: 12
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- Authors
- Rothberg, A. E., McEwen, L. N., Kraftson, A. T., Ajluni, N., Fowler, C. E., Nay, C. K., Miller, N. M., Burant, C. F., & Herman, W. H.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Rothberg, Amy E
- ORCID
- Venue
- BMJ Open Diabetes Research & Care
- Publisher
- BMJ
- Published
- 2017-02
- Volume
- 5
- Issue
- 1
- Pages
- e000341
- ISSN
- 2052-4897 (ISSN-L)
- PMC
- PMC5337678
- OpenAlex
- W2591268974
- Cited by
- 92
- References
- 13
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 13 · 2023: 10 · 2022: 11 · 2021: 14 · 2020: 10 · 2019: 7 · 2018: 7 · 2017: 3
- FWCI
- 5.84
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- BMJ Open Diabetes Research & Care (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (DK081943, DK089503, P30DK092926)
- Dr. Robert C. and Veronica Atkins Foundation
- A. Alfred Taubman Medical Research Institute
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- weight loss, waist circumference, metabolic syndrome, abdominal obesity, obesity, behavioral weight management, blood pressure, lipids, LDL cholesterol, HbA1c, glycemia
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