Psychological interventions to improve glycemic control in adults with type 2 diabetes: a systematic review and meta-analysis
Open accessAbstract
The quality of evidence that psychological interventions are effective in improving glycemic control in adults with type 2 diabetes (T2D) is weak. We conducted a systematic review and meta-analysis of psychological interventions in T2D to assess whether their effectiveness in improving glycemic levels has improved over the past 30 years. We applied the protocol of a systematic review and aggregate meta-analysis conducted to January 2003. We added network meta-analysis (NMA) to compare intervention and control group type against usual care. MEDLINE, Cumulative Index to Nursing and Allied Health Literature, PsycINFO, EMBASE, Cochrane Controlled Trials Database, Web of Science, and Dissertation Abstracts International were searched from January 2003 to July 2018. Only randomized controlled trials (RCT) of psychological interventions for adults with T2D reported in any language were included. The primary outcome was change in glycemic control (glycated hemoglobin (HbA1c) in mmol/mol). Data were extracted from study reports and authors were contacted for missing data. 94 RCTs were eligible for inclusion in the systematic review since the last review. In 70 RCTs (n=14 796 participants) the pooled mean difference in HbA1c in those randomized to psychological intervention compared with control group was −0.19 (95% CI −0.25 to −0.12), equivalent to a reduction in HbA1c of 3.7 mmol/mol, with moderate heterogeneity across studies (I 2=64.7%, p<0.001). NMA suggested the probability of intervention effectiveness is highest for self-help materials, cognitive–behavioral therapy, and counseling, compared with usual care. Limitations of this study include that there is a possibility that some studies may have been missed if diabetes did not appear in the title or abstract. The effectiveness of psychological interventions for adults with T2D have minimal clinical benefit in improving glycemic control. PROSPERO registration number: CRD42016033619.
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Interventions' effects on glycemic control and self-care behaviors were inconsistent.
“However, interventions' effects on glycemic control and self-care behaviors were inconsistent (Winkley et al., 2020).”
From Effectiveness of acceptance and commitment therapy in people with type 2 diabetes mellitus: A systematic review and meta‐analysis. (2024) · cites this paper as Winkley et al., 2020
The Results (Synthesis of results) report substantial heterogeneity in glycemic-control effects across trials, supporting the description of those effects as inconsistent. The Results (Additional analyses, non-protocol) identify studies focused on self-management behaviors, but do not report whether intervention effects on those behaviors were inconsistent. (LLM, conf=0.84)
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“…disminuir la Hemoglobina Glicosilada (HbA1C), sosteniendo su efecto a corto y mediano plazo (González-Burboa et al., 2019; Uchendu & Blake, 2016; Winkley et al., 2020); además, de mejorar la calidad de vida, la AT, el bien-estar psicológico y disminuir síntomas asociados a trastornos del estado…”
Morrissey, E., Dinneen, S., & Doherty, A. (2021) · Mental Health, Diabetes and Endocrinology · doi:10.1017/9781911623625.008
- Authors
- Winkley, K., Upsher, R., Stahl, D., Pollard, D., Brennan, A., Heller, S. R., & Ismail, K.
- Affiliations
- King's College London (GB)
- University of Sheffield (GB)
- Corresponding author
- Winkley, Kirsty
- ORCID
- Venue
- BMJ Open Diabetes Research & Care
- Publisher
- BMJ
- Published
- 2020-04
- Volume
- 8
- Issue
- 1
- Pages
- e001150
- ISSN
- 2052-4897 (ISSN-L)
- PMC
- PMC7254106
- OpenAlex
- W3016181541
- Cited by
- 41
- References
- 38
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 12 · 2023: 5 · 2022: 10 · 2021: 5
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMJ Open Diabetes Research & Care (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Research Portal (King's College London) (submittedVersion, cc-by)
- Greater South Information System
- Funders
- Health Technology Assessment Programme (12/213/10)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- psychological intervention, type 2 diabetes, glycemic control, HbA1c, cognitive behavioral therapy, counseling, self-help materials, usual care
- MeSH terms
- Psychosocial Intervention, Glycemic Control, Adult, Diabetes Mellitus, Type 2, Glycated Hemoglobin, Humans, Cognitive Behavioral Therapy
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