Cited by 72Schizophrenia research and treatmentPsychiatric care and mental health servicesHealth Systems, Economic Evaluations, Quality of Life

Economic impact of early intervention in psychosis services: results from a longitudinal retrospective controlled study in England

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Tsiachristas, Apostolos, Thomas, Tony, Leal, Jose, Lennox, Belinda R·2016·BMJ Open

Abstract

Objectives: To demonstrate the costs, outcomes and economic impact of early intervention in psychosis (EIP) services. Design: Longitudinal retrospective observational study of service usage and outcome data from mental health and acute care services for all those with a diagnosis of psychosis in contact with mental health services over a 3-year period (April 2010–March 2013). Setting: Thames Valley and South Midlands region in England (region covered by Oxford Academic Health Science Network). Participants: 3674 people with psychosis, aged 16–35 years. Interventions: EIP team or other community mental health teams. Main outcome measures: Change in housing status, change in employment status and improvement on each of the four domains of the Health of the Nation Outcome Scale (HONOS) questionnaire. Costs of mental and acute health inpatient, outpatient and community service use were also included in the study. Results: Patients in EIP services were 116% more likely (95% CI 1.263 to 3.708) to gain employment, 52% more likely to become accommodated in a mainstream house (95% CI 0.988 to 2.326) and 17% more likely to have an improvement in the emotional well-being domain of the HONOS questionnaire (95% CI 1.067 to 1.285), as compared to those in non-EIP services. Annual National Health Service (NHS) costs were also significantly lower for patients using EIP services compared to non-users. The mean annual NHS cost savings associated with EIP were £4031 (95% CI £1281 to £6780). These mostly came from lower mental health inpatient costs (£4075, 95% CI £1164 to £6986), lower acute hospital outpatient costs (£59, 95% CI £9 to £109), lower accident and emergency costs (£31, 95% CI £12 to £51), and higher mental health community costs (£648, 95% CI £122 to £1175). If all people with a first-episode psychosis across England were to be treated by EIP services, the savings in societal costs would be an estimated £63.3 million per year, of which £33.5 million would be in NHS costs. Conclusions: Treatment within an EIP service is associated with better health and social outcomes, and reduced costs.

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  • In the UK, models and individual patient data analyses have reported cost savings and increased benefits (such as improvements on clinical outcome scales) associated with early intervention in psychosis services.

    “In the UK, models and individual patient data analyses have reported cost savings and increased benefits (such as improvements on clinical outcome scales) associated with early intervention in psychosis services.”

    From The Lancet Psychiatry Commission on youth mental health (2024) · cites this paper as [425]

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Authors
Tsiachristas, A., Thomas, T., Leal, J., & Lennox, B. R.
Affiliations
  • University of Oxford (GB)
  • Janssen (United Kingdom) (GB)
  • Warneford Hospital (GB)
Corresponding author
Lennox, Belinda R
Venue
BMJ Open
Publisher
BMJ
Published
2016-10
Volume
6
Issue
10
Pages
e012611
ISSN
2044-6055 (ISSN-L)
OpenAlex
W2539412591
Cited by
72
References
0
Citations by year
2026: 5 · 2025: 9 · 2024: 9 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 7 · 2019: 12 · 2018: 8 · 2017: 8
FWCI
8.29
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • BMJ Open (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
National Institute for Health Research (CLAHRC Oxford)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
  • Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Keywords
early intervention in psychosis, first-episode psychosis, economic impact, cost reduction, employment effects, housing stability, mental health service utilization, acute hospitalization, community mental health services, young people with psychosis, NHS costs, social costs, mental health policy evaluation, England, Health of the Nation Outcome Scales
MeSH terms
Adolescent, Adult, Community Health Services, Cost-Benefit Analysis, Delivery of Health Care, Employment, England, Female, Health Status, Housing, Humans, Longitudinal Studies, Male, Mental Health Services, Psychotic Disorders, Surveys and Questionnaires, Retrospective Studies, State Medicine, Health Care Costs, Young Adult

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