The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Early rehabilitation to prevent postintensive care syndrome in patients with critical illness: a systematic review and meta-analysis
Open accessAbstract
Introduction: We examined the effectiveness of early rehabilitation for the prevention of postintensive care syndrome (PICS), characterised by an impaired physical, cognitive or mental health status, among survivors of critical illness. Methods: We performed a systematic literature search of several databases (Medline, Embase and Cochrane Central Register of Controlled Trials) and a manual search to identify randomised controlled trials (RCTs) comparing the effectiveness of early rehabilitation versus no early rehabilitation or standard care for the prevention of PICS. The primary outcomes were short-term physical-related, cognitive-related and mental health-related outcomes assessed during hospitalisation. The secondary outcomes were the standardised, long-term health-related quality of life scores (EuroQol 5 Dimension (EQ5D) and the Medical Outcomes Study 36-Item Short Form Health Survey Physical Function Scale (SF-36 PF)). We used the Grading of Recommendations Assessment, Development and Evaluation approach to rate the quality of evidence (QoE). Results: Six RCTs selected from 5105 screened abstracts were included. Early rehabilitation significantly improved short-term physical-related outcomes, as indicated by an increased Medical Research Council scale score (standardised mean difference (SMD): 0.38, 95% CI 0.10 to 0.66, p=0.009) (QoE: low) and a decreased incidence of intensive care unit-acquired weakness (OR 0.42, 95% CI 0.22 to 0.82, p=0.01, QoE: low), compared with standard care or no early rehabilitation. However, the two groups did not differ in terms of cognitive-related delirium-free days (SMD: −0.02, 95% CI −0.23 to 0.20, QoE: low) and the mental health-related Hospital Anxiety and Depression Scale score (OR: 0.79, 95% CI 0.29 to 2.12, QoE: low). Early rehabilitation did not improve the long-term outcomes of PICS as characterised by EQ5D and SF-36 PF. Conclusions: Early rehabilitation improved only short-term physical-related outcomes in patients with critical illness. Additional large RCTs are needed.
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Long-term cognitive impairment after critical illness
Pandharipande, P. P., Girard, T. D., Jackson, J. C., Morandi, A., Thompson, J. L., Pun, B. T., Brummel, N. E., Hughes, C. G., Vasilevskis, E. E., Shintani, A. K., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301372 · Cited by 2,842
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“3 Postintensive care syndrome (PICS) was established as a new syndrome encompassing new or worsening impairments in physical, cognitive or mental health status that arise after critical illness and persist beyond acute care hospitalisation, with the aim initiating improvements for ICU survivors and their families acro…”
BackgroundLong-term cognitive impairment and functional disability among survivors of severe sepsis.
Iwashyna, T. J., Ely, E. W., Smith, D. M., & Langa, K. M. (2010) · JAMA · doi:10.1001/jama.2010.1553 · Cited by 2,582
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One-Year Outcomes in Caregivers of Critically Ill Patients
Cameron, J. I., Chu, L. M., Matte, A., Tomlinson, G., Chan, L., Thomas, C., Friedrich, J. O., Mehta, S., Lamontagne, F., Levasseur, M., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1511160 · Cited by 429
Brummel, N. E., Girard, T. D., Ely, E. W., Pandharipande, P. P., Morandi, A., Hughes, C. G., Graves, A. J., Shintani, A., Murphy, E., Work, B., et al. (2014) · Intensive Care Medicine · doi:10.1007/s00134-013-3136-0 · Cited by 256
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How to reduce unnecessary duplication: use PROSPERO
Moher, D., Booth, A., & Stewart, L. (2014) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12657 · Cited by 113
Cited by
Vanhorebeek, I., Latronico, N., & Van den Berghe, G. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-05944-4 · Cited by 717
Sepsis therapies: learning from 30 years of failure of translational research to propose new leads
Cavaillon, J., Singer, M., & Skirecki, T. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201810128 · Cited by 319
Metadata
- Authors
- Fuke, R., Hifumi, T., Kondo, Y., Hatakeyama, J., Takei, T., Yamakawa, K., Inoue, S., & Nishida, O.
- Venue
- BMJ Open
- Publisher
- BMJ
- Published
- 2018-05
- Volume
- 8
- Issue
- 5
- Pages
- e019998
- ISSN
- 2044-6055 (ISSN-L)
- OpenAlex
- W2800935289
- Cited by
- 262
- References
- 10
- FWCI
- 4.27
- Type
- journal article
- Language
- en
- Open access
- gold
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- Fuke, R., Hifumi, T., Kondo, Y., Hatakeyama, J., Takei, T., Yamakawa, K., Inoue, S., & Nishida, O. (2018). Early rehabilitation to prevent postintensive care syndrome in patients with critical illness: a systematic review and meta-analysis. BMJ Open. https://doi.org/10.1136/bmjopen-2017-019998
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