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Rationale and design of TransplantLines: a prospective cohort study and biobank of solid organ transplant recipients
Open accessAbstract
INTRODUCTION: In the past decades, short-term results after solid organ transplantation have markedly improved. Disappointingly, this has not been accompanied by parallel improvements in long-term outcomes after transplantation. To improve graft and recipient outcomes, identification of potentially modifiable risk factors and development of biomarkers are required. We provide the rationale and design of a large prospective cohort study of solid organ transplant recipients (TransplantLines). METHODS AND ANALYSIS: TransplantLines is designed as a single-centre, prospective cohort study and biobank including all different types of solid organ transplant recipients as well as living organ donors. Data will be collected from transplant candidates before transplantation, during transplantation, at 3 months, 6 months, 1 year, 2 years and 5 years, and subsequently every 5 years after transplantation. Data from living organ donors will be collected before donation, during donation, at 3 months, 1 year and 5 years after donation, and subsequently every 5 years. The primary outcomes are mortality and graft failure. The secondary outcomes will be cause-specific mortality, cause-specific graft failure and rejection. The tertiary outcomes will be other health problems, including diabetes, obesity, hypertension, hypercholesterolaemia and cardiovascular disease, and disturbances that relate to quality of life, that is, physical and psychological functioning, including quality of sleep, and neurological problems such as tremor and polyneuropathy. ETHICS AND DISSEMINATION: Ethical approval has been obtained from the relevant local ethics committee. The TransplantLines cohort study is designed to deliver pioneering insights into transplantation and donation outcomes. The study design allows comprehensive data collection on perioperative care, nutrition, social and psychological functioning, and biochemical parameters. This may provide a rationale for future intervention strategies to more individualised, patient-centred transplant care and individualisation of treatment. TRIAL REGISTRATION NUMBER: NCT03272841.
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“was approved by the Institutional Review Board of the University Medical Center Groningen (UMCG; decision METc 2014/077 on 25 August 2014), adhered to the UMCG Biobank Regulation, the Declaration of Helsinki, and the Declaration of Istanbul, and collected informed consent from all the participants.”
From Pharmacometabolomics Study of Sulfamethoxazole and Trimethoprim in Kidney Transplant Recipients: Real-World Metabolism and Urinary Excretion (2025) · cites this paper as [25]
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Characteristics and Dysbiosis of the Gut Microbiome in Renal Transplant Recipients
Swarte, J. C., Douwes, R. M., Hu, S., Vila, A. V., Eisenga, M. F., van Londen, M., Neto, A. W. G., Weersma, R. K., Harmsen, H. J. M., & Bakker, S. J. L. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9020386 · Cited by 110
Gut microbiome dysbiosis is associated with increased mortality after solid organ transplantation
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ter Braake, A. D., Eelderink, C., Zeper, L. W., Pasch, A., Bakker, S. J. L., de Borst, M. H., Hoenderop, J. G. J., & de Baaij, J. H. F. (2019) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfz190 · Cited by 89
Stam, S. P., Eisenga, M. F., Neto, A. W. G., van Londen, M., de Meijer, V. E., van Beek, A. P., Gansevoort, R. T., & Bakker, S. J. L. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12399 · Cited by 48
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Metadata
- Authors
- Eisenga, M. F., Gomes-Neto, A. W., van Londen, M., Ziengs, A. L., Douwes, R. M., Stam, S. P., Osté, M. C. J., Knobbe, T. J., Hessels, N. R., Buunk, A. M., Annema, C., Siebelink, M. J., Racz, E., Spikman, J. M., Bodewes, F. A. J. A., Pol, R. A., Berger, S. P., Drost, G., Porte, R. J., Leuvenink, H. G. D., Damman, K., Verschuuren, E. A. M., de Meijer, V. E., Blokzijl, H., & Bakker, S. J. L.
- Affiliations
- University Medical Center Groningen (NL)
- Corresponding author
- Eisenga, Michele F
- ORCID
- Eisenga, Michele F
- Douwes, Rianne M
- Stam, Suzanne P
- Osté, Maryse C J
- Knobbe, Tim J
- Hessels, Niek R
- Buunk, Anne M
- Annema, Coby
- Siebelink, Marion J
- Spikman, Jacoba M
- Bodewes, Frank A J A
- Pol, Robert A
- Berger, Stefan P
- Drost, Gea
- Porte, Robert J
- Leuvenink, Henri G D
- Damman, Kevin
- Verschuuren, Erik A M
- Blokzijl, Hans
- Bakker, Stephan J L
- Venue
- BMJ Open
- Publisher
- BMJ
- Published
- 2018-12
- Volume
- 8
- Issue
- 12
- Pages
- e024502
- ISSN
- 2044-6055 (ISSN-L)
- PMC
- PMC6318532
- OpenAlex
- W2908082263
- Cited by
- 141
- References
- 77
- Citations by year
- 2026: 20 · 2025: 23 · 2024: 30 · 2023: 17 · 2022: 18 · 2021: 17 · 2020: 11 · 2019: 5
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- BMJ Open (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by-nc)
- HighWire Press Open Archive (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by-nc)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- Astellas BV
- Topics
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Organ Donation and Transplantation
- Keywords
- solid organ transplantation, living donor, transplant recipients, biobanks, graft failure, mortality, graft rejection, long-term outcomes, risk factors, biomarkers, post-transplant complications, diabetes mellitus, cardiovascular disease, quality of life, sleep disorders, neurological complications
- MeSH terms
- Graft Survival, Humans, Netherlands, Tissue and Organ Procurement, Prospective Studies, Research Design, Time Factors, Tissue Banks, Organ Transplantation, Living Donors, Observational Studies as Topic, Transplant Recipients
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