What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapies in real-world depressed patients? A reanalysis of the STAR*D study’s patient-level data with fidelity to the original research protocol

Pigott, H Edmund; Kim, Thomas; Xu, Colin; Kirsch, Irving; Amsterdam, Jay

doi:10.1136/bmjopen-2022-063095

What are the treatment remission, response and extent of improvement rates after up to four trials of antidepressant therapies in real-world depressed patients? A reanalysis of the STAR*D study’s patient-level data with fidelity to the original research protocol

Objective Reanalyse the patient-level data set of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study with fidelity to the original research protocol and related publications. Design The study was open label and semirandomised examining the effectiveness of up to four optimi…