Probiotics, prematurity and neurodevelopment: follow-up of a randomised trial
Open accessAbstract
OBJECTIVE: To determine the impact of one probiotics combination on the neurodevelopment of very preterm children at 2-5 years corrected gestational age (CA). DESIGN: Follow-up study of survivors of a double-blinded, placebo-controlled, randomised trial of probiotic effects on late-onset sepsis in very preterm infants that found reduced necrotising enterocolitis. SETTING: 10 tertiary perinatal centres in Australia and New Zealand. PATIENTS: 1099 very preterm infants born <32 weeks' gestation and weighing <1500 g. INTERVENTION: ) or placebo administered from birth until discharge home or term CA, whichever came sooner. MAIN OUTCOME MEASURES: 2SD if >42 months' CA), blindness or deafness. RESULTS: Outcome data were available for 735 (67%) participants, with 71 deaths and 664/1028 survivors assessed at a mean age of 30 months. Survival free of major neurodevelopmental impairment was comparable between groups (probiotics 281 (75.3%) vs placebo 271 (74.9%); relative risk 1.01 (95% CI 0.93 to 1.09)). Rates of deafness were lower in probiotic-treated children (0.6% vs 3.4%). CONCLUSION: to very preterm babies from soon after birth until discharge home or term CA did not adversely affect neurodevelopment or behaviour in early childhood. TRIAL REGISTRATION NUMBER: Australia and New Zealand Clinical Trials Register (ANZCTR): ACTRN012607000144415.
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In one follow-up study of 1,099 very preterm infants, there was no difference in major neurodevelopment outcomes at 3-5 years of age in surviving infants who had received compared to those who had not received probiotics.
“In one follow-up study of 1,099 very preterm infants, there was no difference in major neurodevelopment outcomes at 3–5 years of age in surviving infants who had received compared to those who had not received probiotics.”
From Emerging issues in probiotic safety: 2023 perspectives (2023) · cites this paper as [130]
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Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510004319 · Cited by 1,324 · see citing works
Steenbergen, L., Sellaro, R., van Hemert, S., Bosch, J. A., & Colzato, L. S. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.04.003 · Cited by 671 · see citing works
Davari, S., Talaei, S. A., Alaei, H., & salami, M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.055 · Cited by 290 · see citing works
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Emerging issues in probiotic safety: 2023 perspectives
Merenstein, D., Pot, B., Leyer, G., Ouwehand, A. C., Preidis, G. A., Elkins, C. A., Hill, C., Lewis, Z. T., Shane, A. L., Zmora, N., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2185034 · Cited by 481 · see citing works
Use of Probiotics in Preterm Infants
Poindexter, B., COMMITTEE ON FETUS AND NEWBORN, Cummings, J., Hand, I., Adams-Chapman, I., Aucott, S. W., Puopolo, K. M., Goldsmith, J. P., Kaufman, D., Martin, C., et al. (2021) · Pediatrics · doi:10.1542/peds.2021-051485 · Cited by 171 · see citing works
- Authors
- Jacobs, S. E., Hickey, L., Donath, S., Opie, G. F., Anderson, P. J., Garland, S. M., & Cheong, J. L. Y.
- Affiliations
- Royal Women's Hospital (AU)
- Royal Children's Hospital (AU)
- The University of Melbourne (AU)
- Corresponding author
- Jacobs, Susan E
- Venue
- BMJ Paediatrics Open
- Publisher
- BMJ
- Published
- 2017-11
- Volume
- 1
- Issue
- 1
- Pages
- e000176
- ISSN
- 2399-9772 (ISSN-L)
- PMC
- PMC5862156
- OpenAlex
- W2770323313
- Cited by
- 61
- References
- 3
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 8 · 2023: 10 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 2
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- BMJ Paediatrics Open (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- ResearchOnline at James Cook University (James Cook University) (submittedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc)
- Deakin Research Online (Deakin University) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc)
- Figshare (submittedVersion, cc-by-nc)
- Funders
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- probiotics, very preterm infants, brain development, neurodevelopmental impairment, hearing loss, blindness, late-onset sepsis, necrotizing enterocolitis
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