Cited by 170Pediatric Pain Management TechniquesPain Mechanisms and TreatmentsInfant Health and Development

“Sucrose analgesia”: absorptive mechanism or taste perception?

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Ramenghi, Luca A, Evans, David J, Levene, Malcolm I·1999·Archives of Disease in Childhood - Fetal and Neonatal Edition

Abstract

It remains unclear whether “sucrose analgesia” is related to a pre- or postabsorptive mechanism. In a double blind cross over study sucrose reduced the pain response of preterm infants exposed to heel prick blood samples only when it was administered into the mouth. It was ineffective when administered intragastrically.

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Crossref · 10.1136/fn.80.2.f146

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  • The pain-relieving effect of sweet taste may depend on afferent signals from the mouth rather than on gastric or metabolic changes.

    “Given that the administration of sucrose by direct stomach loading was ineffective (37), it may be that afferent signals from the mouth, rather than gastric or metabolic changes, are responsible for the analgesic properties of sweet tastes.”

    From Sweetness and Food Preference (2012) · cites this paper as [37]

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Research works printed but not linked: 2

  1. [4]4. Gunning RR, Graber AJ. Biocativity of instant glucose:fail- ure of absorption through oral mucosa. JAMA 1978;240:1611-12.
  2. [5]5. Breslin PA, Kemp S, Beauchamp GK. Single sweetness sig- nal. Nature 1994;369:447-8.

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Authors
Ramenghi, L. A., Evans, D. J., & Levene, M. I.
Affiliations
Leeds General Infirmary (GB)
Corresponding author
Ramenghi, Luca A
Venue
Archives of Disease in Childhood - Fetal and Neonatal Edition
Publisher
BMJ
Published
1999-03-01
Volume
80
Issue
2
Pages
F146-F147
ISSN
  • 1359-2998 (ISSN-L)
  • 1468-2052
OpenAlex
W1976257536
Cited by
170
References
7
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 7 · 2014: 4 · 2013: 9 · 2012: 11
FWCI
8.60
Type
journal article
Language
en
Open access
Locations
  • Archives of Disease in Childhood Fetal & Neonatal (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Health Professions › Pharmacy › Infant Health and Development
Keywords
sucrose analgesia, preterm infants, heel prick blood sampling, pain response, taste perception, neonatal pain
MeSH terms
Administration, Oral, Analgesics, Blood Specimen Collection, Double-Blind Method, Humans, Infant, Newborn, Intubation, Gastrointestinal, Sucrose, Taste, Cross-Over Studies, Statistics, Nonparametric

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