“Sucrose analgesia”: absorptive mechanism or taste perception?
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It remains unclear whether “sucrose analgesia” is related to a pre- or postabsorptive mechanism. In a double blind cross over study sucrose reduced the pain response of preterm infants exposed to heel prick blood samples only when it was administered into the mouth. It was ineffective when administered intragastrically.
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The pain-relieving effect of sweet taste may depend on afferent signals from the mouth rather than on gastric or metabolic changes.
“Given that the administration of sucrose by direct stomach loading was ineffective (37), it may be that afferent signals from the mouth, rather than gastric or metabolic changes, are responsible for the analgesic properties of sweet tastes.”
From Sweetness and Food Preference (2012) · cites this paper as [37]
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Hospitalized Infants Who Hurt: A Sweet Solution With Oral Sucrose
Pasek, T. A., & Huber, J. M. (2012) · Critical Care Nurse · doi:10.4037/ccn2012912 · Cited by 15 · see citing works
A eficácia da sacarose no alívio de dor em neonatos: revisão sistemática da literatura
Gaspardo, C. M., Linhares, M. B. M., & Martinez, F. E. (2005) · Jornal de Pediatria · doi:10.1590/s0021-75572005000800005 · Cited by 15 · see citing works
Gender differences in pain modulation by a sweet stimulus in adults: A randomized study
Kakeda, T., & Ishikawa, T. (2011) · Nursing and Health Sciences · doi:10.1111/j.1442-2018.2010.00573.x · Cited by 14 · see citing works
Dor em neonatos e crianças: avaliação e intervenções não farmacológicas
Linhares, M. B. M., & Doca, F. N. P. (2010) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 14 · see citing works
- Authors
- Ramenghi, L. A., Evans, D. J., & Levene, M. I.
- Affiliations
- Leeds General Infirmary (GB)
- Corresponding author
- Ramenghi, Luca A
- ORCID
- Ramenghi, Luca A
- Venue
- Archives of Disease in Childhood - Fetal and Neonatal Edition
- Publisher
- BMJ
- Published
- 1999-03-01
- Volume
- 80
- Issue
- 2
- Pages
- F146-F147
- ISSN
- 1359-2998 (ISSN-L)
- 1468-2052
- PMC
- PMC1720910
- OpenAlex
- W1976257536
- Cited by
- 170
- References
- 7
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 7 · 2014: 4 · 2013: 9 · 2012: 11
- FWCI
- 8.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Disease in Childhood Fetal & Neonatal (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Keywords
- sucrose analgesia, preterm infants, heel prick blood sampling, pain response, taste perception, neonatal pain
- MeSH terms
- Administration, Oral, Analgesics, Blood Specimen Collection, Double-Blind Method, Humans, Infant, Newborn, Intubation, Gastrointestinal, Sucrose, Taste, Cross-Over Studies, Statistics, Nonparametric
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