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Cited by 14Gut microbiota and healthGastrointestinal motility and disordersInflammatory Bowel Disease

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An ultrastructural study of the effect of neomycin on the colon in the human subject and in the conventional and the germ-free mouse

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Aluwihare, A. P. R.·1971·Gut
DOI 10.1136/gut.12.5.341PMC PMC1411602
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Abstract

An electron microscopic study of the colon of normal mice and human subjects and those treated with neomycin is reported; there is a close resemblance between the mouse and human colons. After rapid disinfection of the colon, there is epithelial cell damage due to a toxic effect of the drug, a reduction in epithelial turnover accompanying the change in flora, and an important reduction in the cellularity of the lamina propria mainly due to a reduction in inflammatory cells. The changes in the lamina propria probably represent changes in the antipathogenetic defences of the host.

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Research works printed but not linked: 27

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Metadata

Authors
Aluwihare, A. P. R.
Affiliations
Royal College of Surgeons of England (GB)
Corresponding author
Aluwihare, A. P. R.
Venue
Gut
Publisher
BMJ
Published
1971-05
Volume
12
Issue
5
Pages
341-349
ISSN
  • 0017-5749 (ISSN-L)
  • 1468-3288
DOI
10.1136/gut.12.5.341
PMC
PMC1411602
OpenAlex
W2052363747
Cited by
14
References
0
Citations by year
2023: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2014: 1 · 2013: 2
FWCI
0.39
Type
journal article
Language
en
Open access
Locations
  • Gut (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Keywords
neomycin, germ-free mice, human colon, epithelial damage, epithelial cell turnover, inflammatory cells, gut microbiota, drug toxicity, host defense against infection
MeSH terms
Animals, Basement Membrane, Cecum, Cell Nucleus, Collagen, Colon, Connective Tissue, Epithelial Cells, Epithelium, Fibroblasts, Germ-Free Life, Humans, Intestinal Mucosa, Microscopy, Electron, Neomycin, Nerve Tissue, Mice

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CoChat. (2026). Citation check: An ultrastructural study of the effect of neomycin on the colon in the human subject and in the conventional and the germ-free mouse. https://app.cochat.ai/papers/10.1136/gut.12.5.341
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Aluwihare, A. P. R. (1971). An ultrastructural study of the effect of neomycin on the colon in the human subject and in the conventional and the germ-free mouse. Gut. https://doi.org/10.1136/gut.12.5.341