Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis.
Open accessAbstract
The frequency of HLA-A3 and HLA-B14 antigens was significantly higher in a series of 51 patients with idiopathic haemochromatosis than in a control group, being respectively 78-4 versus 27-0% and 25-5 versus 3-4%. This finding strongly supports the suggestion that idiopathic haemochromatosis is a genetic disease and suggests that the gene(s) responsible for the disease may be linked to the histocompatibility genes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Hemochromatosis was one of the first genetic diseases to be linked to a discrete chromosomal position through Simon's finding that hemochromatosis patients were disproportionately likely to have particular HLA haplotypes.
“It was one of the first genetic diseases to be linked to a discrete chromosomal position, through the groundbreaking work of Simon, an astute French physician-scientist who found that hemochromatosis patients were disproportionately likely to have particular HLA haplotypes.120”
From Forging a field: the golden age of iron biology. (2008) · cites this paper as [120]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nonparametric Statistics for the Behavioral Sciences
Guitton, H., & Siegel, S. (1958) · Revue économique · doi:10.2307/3498751 · Cited by 35,281 · see citing works
Nonparametric Statistics : for the Behavioral Sciences
Siegel, S. (1956) · UCLA - Biblioteca de Ciencias y Tecnologia Felix Morales Bueno · Cited by 3,314 · see citing works
NONPARAMETRIC STATISTICS FOR THE BEHAVIORAL SCIENCES
Sidney, S. (1957) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-195707000-00032 · Cited by 2,245 · see citing works
ANKYLOSING SPONDYLITIS AND HL-A 27
Brewerton, D. A., Hart, F. D., Nicholls, A., Caffrey, M., James, D. C. O., & Sturrock, R. D. (1973) · The Lancet · doi:10.1016/s0140-6736(73)91360-3 · Cited by 1,838 · see citing works
High Association of an HL-A Antigen, W27, with Ankylosing Spondylitis
Schlosstein, L. H., Terasaki, P. I., Bluestone, R., et al. (1973) · New England Journal of Medicine · doi:10.1056/nejm197304052881403 · Cited by 1,390 · see citing works
HL‐A and Disease Associations ‐ A Survey
Svejgaard, A., Platz, P., Ryder, L. P., Nielsen, L. S., & Thomsen, M. (1975) · Immunological Reviews · doi:10.1111/j.1600-065x.1975.tb01550.x · Cited by 275 · see citing works
Hemochromatosis and Hemosiderosis
MacDonald, R. A. (1963) · Kanzo · doi:10.2957/kanzo.5.34 · Cited by 121 · see citing works
The association of the HL-A antigens with diseases
Dausset, J. B., Degos, L., & HORS, J. (1974) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(74)90029-4 · Cited by 79 · see citing works
HEMOCHROMATOSE IDIOPATHIQUE. MALADIE ASSOCIEE A L'ANTIGENE TISSULAIRE HL-A3.
Simon, M., Pawlotsky, Y., Bourel, M., Fauchet, R., & GENETET, B. (1975) · La Nouvelle presse médicale · Cited by 67 · see citing works
Self-citation[Letter: Idiopathic hemochromatosis associated with HL-A 3 tissular antigen].
Simon, M., Pawlotsky, Y., Bourel, M., et al. (1975) · PubMed · Cited by 67 · see citing works
Self-citationIdiopathic haemochromatosis: An autosomal recessive disease
Saddi, R., & Feingold, J. (1974) · Clinical Genetics · doi:10.1111/j.1399-0004.1974.tb01688.x · Cited by 56 · see citing works
Data on the HL‐A linkage group
Lamm, L. U., Thorsen, I., PETERSEN, G. B., et al. (1975) · Annals of Human Genetics · doi:10.1111/j.1469-1809.1975.tb00628.x · Cited by 45 · see citing works
Daguillard, F., & Beaudoin, R. (1976) · PubMed · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- Alexandre, J-L. (1975). Etude de l'Heredite dans l'Hemo- chromatose, a Propos de 106 Enquetes Familiales. Thesis: Rennes.
- Colombani, J., D'Amaro, J., Gabb, B., Smith, G., and Svejgaard, A. (1973). Micro-technique of platelet comple- ment fixation. In Manual of Tissue Typing Techniques, pp. 69-74. Edited by J. G. Ray, D. B. Hare, and D. E. Kayhoe. (DHEW Publication No. (NIH) 74-545): Bethesda, Maryland.
- Dausset, J. (1973). Micro-lymphocytotoxicity technique. In Manual of Tissue Typing Techniques, pp. 28-33. Edited by J. G. Ray, D. B. Hare, and D. E. Kayhoe. (DHEW Pub- lication No. (NIH) 74-545): Bethesda: Maryland.
- Sheldon, J. H. (1935). Haemochromatosis. Oxford University Press: London.
- WHO-IUIS Terminology Committee (1975). Nomenclature for factors of the HLA system. In Proceedings of the Sixth International Histocompatibility Workshop Con- ference. Munksgaard: Copenhagen. (in press). on September 9, 2023 by guest. Protected by copyright. http://gut.bmj.com/ Gut: first published as 10.1136/gut.17.5.332 on 1 May 1976. Downloaded from
Cited by
Sorted by citations
A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
Feder, J. N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D. A., Basava, A., Dormishian, F., Domingo, R., Ellis, M. C., Fullan, A., et al. (1996) · Nature Genetics · doi:10.1038/ng0896-399 · Cited by 3,664 · see citing works
Forging a field: the golden age of iron biology.
Andrews, N. C. (2008) · Blood · doi:10.1182/blood-2007-12-077388 · Cited by 623 · see citing works
Rubio, J. P., Tubridy, N., Bahlo, M., Stankovich, J., Burfoot, R., Butzkueven, H., Chapman, C., Johnson, L., Marriott, M., Mraz, G., et al. (2004) · Human Genetics · doi:10.1007/s00439-004-1095-9 · Cited by 43 · see citing works
Evidence for heterogeneity in hereditary hemochromatosis
Muir, W. A., Mclaren, G. D., Braun, W., & Askari, A. (1984) · The American Journal of Medicine · doi:10.1016/0002-9343(84)90991-4 · Cited by 42 · see citing works
Spontaneous Yersinia enterocolitica peritonitis in idiopathic hemochromatosis
Capron, J.-P., Capron-Chivrac, D., Tossou, H., Delamarre, J., & Eb, F. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90207-5 · Cited by 33 · see citing works
- Authors
- Simon, M., Bourel, M., Fauchet, R., & Genetet, B.
- Affiliations
- Inserm (FR)
- ORCID
- Simon, M
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1976-05
- Volume
- 17
- Issue
- 5
- Pages
- 332-334
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1411133
- OpenAlex
- W2170463264
- Cited by
- 389
- References
- 13
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2021: 2 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 5 · 2016: 6 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 5
- FWCI
- 13.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Keywords
- idiopathic hemochromatosis, HLA-A3, HLA-B14, HLA antigens, genetic susceptibility, histocompatibility genes, genetic linkage, disease association
- MeSH terms
- Adult, Alleles, Female, Hemochromatosis, Histocompatibility Antigens, HLA Antigens, Humans, Male, Middle Aged
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
