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Cited by 454

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Natural history of compensated viral cirrhosis: a prospective study on the incidence and hierarchy of major complications

Open access
Benvegnù, L, Gios, M, Boccato, S, Alberti, A·2004·Gut
DOI 10.1136/gut.2003.020263
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Abstract

Background and aims: The natural history of initially compensated cirrhosis due to hepatitis B (HBV) or hepatitis C (HCV) virus is only partially defined. We have investigated morbidity and mortality rates and the hierarchy of complications in compensated viral cirrhosis over a long follow up period. Patients and Methods: A cohort of Italian patients with initially compensated cirrhosis of viral aetiology were followed up at six monthly intervals with laboratory tests to identify major complications (ascites, gastrointestinal bleeding, portal-systemic encephalopathy, hepatocellular carcinoma) and to assess the progression of Child’s stage and mortality rate due to liver related causes. Results: Between 1986 and 1996, 312 patients (43 HBV positive, 254 HCV positive, and 15 HBV and HCV coinfected) were included. During a median follow up of 93 (range 14–194) months, 102 (32.6%) patients developed at least one complication (HCV positive 31.1%; HBV positive 34.8%; HBV and HCV coinfected 53.3%). Overall, the most frequent complication was hepatocellular carcinoma which occurred in 65 (20.8%) cases, followed by ascites (61 cases, 19.5%), gastrointestinal bleeding (14 cases, 4.5%), and portal-systemic encephalopathy (six cases, 1.9%). Progression of Child’s stage was observed in 62 patients (19.8%). Death from liver disease occurred in 58 (18.6%) cases and in 70.7% this was due to hepatocellular carcinoma. Hepatocellular carcinoma was the first complication to develop in 59 cases and represented the most frequent first complication in both HCV and HBV/ HCV related cirrhosis. Conclusions: These results indicate significant morbidity and mortality during the first decade after diagnosis of compensated cirrhosis due to HBV and/or HCV, and identify hepatocellular carcinoma as the most frequent and life threatening complication, particularly in HCV positive cases.

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Metadata

Authors
Benvegnù, L., Gios, M., Boccato, S., & Alberti, A.
Venue
Gut
Publisher
BMJ
Published
2004-04-13
Volume
53
Issue
5
Pages
744-749
ISSN
  • 0017-5749 (ISSN-L)
  • 1468-3288
DOI
10.1136/gut.2003.020263
OpenAlex
W2137230959
Cited by
454
References
37
FWCI
19.98
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Natural history of compensated viral cirrhosis: a prospective study on the incidence and hierarchy of major complications. https://app.cochat.ai/papers/10.1136/gut.2003.020263
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Benvegnù, L., Gios, M., Boccato, S., & Alberti, A. (2004). Natural history of compensated viral cirrhosis: a prospective study on the incidence and hierarchy of major complications. Gut. https://doi.org/10.1136/gut.2003.020263

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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