Cited by 499Gastrointestinal motility and disordersGut microbiota and healthMicroscopic Colitis

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Small intestinal bacterial overgrowth in patients with irritable bowel syndrome

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Posserud, Iris, Stotzer, Per-Ove, Björnsson, Einar S, Abrahamsson, Hasse, Simrén, Magnus·2007·Gut

DOI 10.1136/gut.2006.108712PMC PMC1954873

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Abstract

Background: Small intestinal bacterial overgrowth (SIBO) has been proposed to be common in irritable bowel syndrome (IBS), with altered small-bowel motility as a possible predisposing factor. Aim: To assess the prevalence of SIBO, by culture of small-bowel aspirate, and its correlation to symptoms and motility in IBS. Methods: 162 patients with IBS who underwent small-bowel manometry and culture of jejunal aspirate were included. Cultures from 26 healthy subjects served as controls. Two definitions of altered flora were used: the standard definition of SIBO (⩾10 5 colonic bacteria/ml), and mildly increased counts of small-bowel bacteria (⩾95th centile in controls). Results: SIBO (as per standard definition) was found in 4% of both patients and controls. Signs of enteric dysmotility were seen in 86% of patients with SIBO and in 39% of patients without SIBO (p = 0.02). Patients with SIBO had fewer phase III activities (activity fronts) than patients without SIBO (p = 0.08), but otherwise no differences in motility parameters were seen. Mildly increased bacterial counts (⩾5×10 3 /ml) were more common in patients with IBS than in controls (43% vs 12%; p = 0.002), but this was unrelated to small intestinal motility. No correlation between bacterial alterations and symptom pattern was observed. Conclusions: The data do not support an important role for SIBO according to commonly used clinical definitions, in IBS. However, mildly increased counts of small-bowel bacteria seem to be more common in IBS, and needs further investigation. Motility alterations could not reliably predict altered small-bowel bacterial flora.

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“Prolonged malabsorption can result in nutrient deficiencies, further exacerbating gastrointestinal and systemic health issues (Posserud et al. 2007).”
Síndrome de intestino irritable y sobrecrecimiento bacteriano de intestino delgado
Villar-Chávez, A. S., & Ruiz-Romero, D. (2025) · Clínicas de gastroenterología de México · doi:10.24875/cgm.m25000008
Nahrungsmittelallergien und -unverträglichkeiten inkl. Zöliakie
Raithel, M. (2025) · Elsevier eBooks · doi:10.1016/b978-3-437-21164-5.00002-7
Biofilm Disruption Enhances Antimicrobial Therapy for Small Intestinal Bacterial Overgrowth and Intestinal Methanogen Overgrowth
Ruscio, M., Guard, G., O'Dwyer, D. D., Darville, R. L., Klopf, H., Abbott, R., & Spiridigliozzi, S. (2025) · Cureus · doi:10.7759/cureus.99116
“Clinically, SIBO/IMO may lead to maldigestion, malabsorption, and altered motility [4-6], and may be implicated in the pathogenesis of both functional and organic gastrointestinal disorders.”
Physiopathologie du syndrome de l’intestin irritable (SII)
Jouet, P. (2013) · Côlon & Rectum · doi:10.1007/s11725-013-0456-8
Role du fructose dans la physiopathologie du syndrome de l'intestin irritable
Melchior, C. (2018) · theses.fr (ABES) · doi:10.70675/b07649edz908dz4d73za666z0112bc94cdf8
Les protéases et leurs inhibiteurs sécrétés par la cellule épithéliale : acteurs de l'inflammation et de la douleur
Rolland-Fourcade, C. (2017) · theses.fr (ABES) · doi:10.70675/c9123f96z8850z4ac8z9b3fz4bf68951b981
Saudi consensus statements on the management of irritable bowel syndrome
Alzahrani, M. A., Alzubide, S. R., Abufarhaneh, E. H., Alqaraawi, A., Al-Amro, R., Alhalafi, M., Alamr, A., Alsulaimi, M. S., Alshumrani, W., Alotaibi, S., et al. (2026) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_472_25
Is MASLD Not Just a Liver Disease? Bidirectional Gut–Liver Crosstalk as a Driver of Chronic Liver Disease
Mărginean, I. C., Cazacu, S. M., Mărginean, C. M., Popescu, M., Iacob, G. A., Popescu, M. S., & Vere, C. C. (2026) · Life · doi:10.3390/life16071076
Do Multi-Omics Approaches Improve the Diagnosis of Microbial Overgrowth Syndromes?
Germano, J. D. F., Leite, G., & Pimentel, M. (2026) · Current Gastroenterology Reports · doi:10.1007/s11894-026-01057-y
“Some causes of IBS have already been supported by data such as bile acid diarrhea [19], mast cell activation [20], and even SIBO itself [21, 22 ].”
15 205Nahrungsmittelallergien
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“88 • • • • • • plus discuté, elle ne serait présente que chez 5 à 10 % des patients (24, 25).”

Authors: Posserud, I., Stotzer, P.-O., Björnsson, E. S., Abrahamsson, H., & Simrén, M.
Affiliations: Sahlgrenska University Hospital (SE)
ORCID: Simrén, Magnus
Venue: Gut
Publisher: BMJ
Published: 2006-12-05
Volume: 56
Issue: 6
Pages: 802-808
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.2006.108712
PMC: PMC1954873
OpenAlex: W2120896017
Cited by: 499
References: 53
Citations by year: 2026: 8 · 2025: 13 · 2024: 7 · 2023: 15 · 2022: 10 · 2021: 18 · 2020: 22 · 2019: 17 · 2018: 22 · 2017: 29 · 2016: 26 · 2015: 34 · 2014: 35 · 2013: 31 · 2012: 31
FWCI: 28.64
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Medical Research Council
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
Keywords: small intestinal bacterial overgrowth, irritable bowel syndrome, small intestine motility, SIBO prevalence
MeSH terms: Adult, Aged, Anti-Bacterial Agents, Bacteria, Bacterial Infections, Breath Tests, Constipation, Diarrhea, Female, Gastrointestinal Motility, Humans, Intestine, Small, Jejunum, Male, Manometry, Middle Aged, Treatment Outcome, Irritable Bowel Syndrome

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Small intestinal bacterial overgrowth in patients with irritable bowel syndrome

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