The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Risk of progression of advanced adenomas to colorectal cancer by age and sex: estimates based on 840 149 screening colonoscopies
Open accessAbstract
Objectives: To derive age and sex specific estimates of transition rates from advanced adenomas to colorectal cancer by combining data of a nationwide screening colonoscopy registry and national data on colorectal cancer (CRC) incidence. Design: Registry based study. Setting: National screening colonoscopy programme in Germany. Patients: Participants of screening colonoscopy in 2003 and 2004 (n = 840 149). Main outcome measures: Advanced adenoma prevalence, colorectal cancer incidence, annual and 10 year cumulative risk of developing CRC among carriers of advanced adenomas according to sex and age (range 55–80+ years) Results: The age gradient is much stronger for CRC incidence than for advanced adenoma prevalence. As a result, projected annual transition rates from advanced adenomas to CRC strongly increase with age (from 2.6% in age group 55–59 years to 5.6% in age group ⩾80 years among women, and from 2.6% in age group 55–59 years to 5.1% in age group ⩾80 years among men). Projections of 10 year cumulative risk increase from 25.4% at age 55 years to 42.9% at age 80 years in women, and from 25.2% at age 55 years to 39.7% at age 80 years in men. Conclusions: Advanced adenoma transition rates are similar in both sexes, but there is a strong age gradient for both sexes. Our estimates of transition rates in older age groups are in line with previous estimates derived from small case series in the pre-colonoscopy era independent of age. However, our projections for younger age groups are considerably lower. These findings may have important implications for the design of CRC screening programmes.
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Protection From Colorectal Cancer After Colonoscopy: A Population-Based, Case–Control Study
Brenner, H., Chang-Claude, J., Seiler, C. M., Rickert, A., & Hoffmeister, M. (2011) · Annals of Internal Medicine · doi:10.7326/0003-4819-154-1-201101040-00004 · Cited by 773
Self-citationSignaling pathways involved in colorectal cancer: pathogenesis and targeted therapy
Li, Q., Geng, S., Luo, H., Wang, W., Mo, Y.-Q., Luo, Q., Wang, L., Song, G.-B., Sheng, J.-P., & Xu, B. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01953-7 · Cited by 546
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Metadata
- Authors
- Brenner, H., Hoffmeister, M., Stegmaier, C., Brenner, G., Altenhofen, L., & Haug, U.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2007-06-25
- Volume
- 56
- Issue
- 11
- Pages
- 1585-1589
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2146430570
- Cited by
- 438
- References
- 22
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Brenner, H., Hoffmeister, M., Stegmaier, C., Brenner, G., Altenhofen, L., & Haug, U. (2007). Risk of progression of advanced adenomas to colorectal cancer by age and sex: estimates based on 840 149 screening colonoscopies. Gut. https://doi.org/10.1136/gut.2007.122739
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