The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
The evolution of cancer of the colon and rectum
Abstract
The malignant potential of adenomas of the colon and rectum varies with size, histological type and grade of epithelial atypia. The adenomatous polyp is usually small and has a low malignant potential, whereas tumors with a villous structure are usually larger and have a much higher cancer rate. Severe atypia is more common in villous adenomas than in adenomatous polyps. Evidence is presented which suggests that most cancers of the colon and rectum have evolved through the polyp‐cancer sequence although the majority of adenomas do not become cancerous during a normal adult life span. The slow evolution of the polyp‐cancer sequence is stressed. The implications of the polyp‐cancer sequence for the design of cancer prevention programmes and the study of the aetiology of large bowel cancer are discussed.
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Cites
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Predisposing causes of intestinal cancer
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Cited by
Edwards, B. K., Ward, E., Kohler, B. A., Eheman, C., Zauber, A. G., Anderson, R. N., Jemal, A., Schymura, M. J., Lansdorp‐Vogelaar, I., Seeff, L. C., et al. (2010) · Cancer · doi:10.1002/cncr.24760 · Cited by 2,002
Natural history of untreated colonic polyps
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The colorectal adenoma–carcinoma sequence
Leslie, A., Carey, F. A., Pratt, N. R., & Steele, R. J. C. (2002) · British Journal of Surgery · doi:10.1046/j.1365-2168.2002.02120.x · Cited by 734
Brenner, H., Hoffmeister, M., Stegmaier, C., Brenner, G., Altenhofen, L., & Haug, U. (2007) · Gut · doi:10.1136/gut.2007.122739 · Cited by 438
Rutter, M. D., East, J., Rees, C. J., Cripps, N., Docherty, J., Dolwani, S., Kaye, P. V., Monahan, K. J., Novelli, M. R., Plumb, A., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-319858 · Cited by 380
Metadata
- Authors
- Muto, T., Bussey, H. J. R., & Morson, B. C.
- Venue
- Cancer
- Publisher
- Wiley
- Published
- 1975-12
- Volume
- 36
- Issue
- 6
- Pages
- 2251-2270
- ISSN
- 0008-543X (ISSN-L)
- 1097-0142
- OpenAlex
- W2043539979
- Cited by
- 2,118
- References
- 13
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Muto, T., Bussey, H. J. R., & Morson, B. C. (1975). The evolution of cancer of the colon and rectum. Cancer. https://doi.org/10.1002/cncr.2820360944
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
