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Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain
Open accessAbstract
OBJECTIVE: The capsaicin receptor TRPV1 (transient receptor potential vanilloid type-1) may play an important role in visceral pain and hypersensitivity states. In irritable bowel syndrome (IBS), abdominal pain is a common and distressing symptom where the pathophysiology is still not clearly defined. TRPV1-immunoreactive nerve fibres were investigated in colonic biopsies from patients with IBS, and this was related to abdominal pain. METHODS: Rectosigmoid biopsies were collected from 23 IBS patients fulfilling Rome II criteria, and from 22 controls. Abdominal pain scores were recorded using a validated questionnaire. TRPV1-, substance P- and neuronal marker protein gene product (PGP) 9.5-expressing nerve fibres, mast cells (c-kit) and lymphocytes (CD3 and CD4) were quantified, following immunohistochemistry with specific antibodies. The biopsy findings were related to the abdominal pain scores. RESULTS: A significant 3.5-fold increase in median numbers of TRPV1-immunoreactive fibres was found in biopsies from IBS patients compared with controls (p<0.0001). Substance P-immunoreactive fibres (p = 0.01), total nerve fibres (PGP9.5) (p = 0.002), mast cells (c-kit) (p = 0.02) and lymphocytes (CD3) (p = 0.03) were also significantly increased in the IBS group. In multivariate regression analysis, only TRPV1-immuno-reactive fibres (p = 0.005) and mast cells (p = 0.008) were significantly related to the abdominal pain score. CONCLUSIONS: Increased TRPV1 nerve fibres are observed in IBS, together with a low-grade inflammatory response. The increased TRPV1 nerve fibres may contribute to visceral hypersensitivity and pain in IBS, and provide a novel therapeutic target.
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“The abundance of mast cells in patients with IBS may correlate with some symptoms of IBS, including bloating and abdominal pain (2, 46).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [2]
In the citing paper
“At the peripheral level, the close interaction between the immune system and the ENS in IBS is demonstrated by the increased infiltration of mast cells in the colonic mucosa in close proximity to enteric nerve fibers and by the increased number of sensory nerve fibers surrounding the mast cells (2, 11, 13).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [2]
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“In addition, human and animal studies have shown anatomical changes in the enteric nervous system (ENS) around inflammatory infiltrates in the gut wall (2, 11, 13).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [2]
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Postinfectious Irritable Bowel Syndrome
Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024
Anand, P., & Bley, K. R. (2011) · British Journal of Anaesthesia · doi:10.1093/bja/aer260 · Cited by 708
Self-citationPathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions
Öhman, L., & Simrén, M. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.4 · Cited by 617
Nilius, B., & SZALLASI, A. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008268 · Cited by 510
Fattori, V., Hohmann, M. S., Rossaneis, A. C., Pinho-Ribeiro, F. A., & Verri, W. A., Jr. (2016) · Molecules · doi:10.3390/molecules21070844 · Cited by 512
Metadata
- Authors
- Akbar, A., Yiangou, Y., Facer, P., Walters, J. R. F., Anand, P., & Ghosh, S.
- Affiliations
- Imperial College London (GB)
- Hammersmith Hospital (GB)
- Corresponding author
- Ghosh, S
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2008-02-27
- Volume
- 57
- Issue
- 7
- Pages
- 923-929
- ISSN
- 0017-5749 (ISSN-L)
- PMC
- PMC2564830
- OpenAlex
- W2165979101
- Cited by
- 526
- References
- 49
- Citations by year
- 2026: 19 · 2025: 16 · 2024: 34 · 2023: 25 · 2022: 21 · 2021: 36 · 2020: 28 · 2019: 27 · 2018: 30 · 2017: 30 · 2016: 41 · 2015: 25 · 2014: 36 · 2013: 39 · 2012: 26
- FWCI
- 29.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Spiral (Imperial College London) (submittedVersion)
- Funders
- GlaxoSmithKline
- London School of Hygiene and Tropical Medicine
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- irritable bowel syndrome, TRPV1, capsaicin receptor, visceral pain, visceral hypersensitivity, abdominal pain, sensory nerve fibers, substance P, mast cells, lymphocytes, colonic mucosa, low-grade inflammation
- MeSH terms
- Adult, Aged, Anxiety, Depression, Female, Humans, Immunoenzyme Techniques, Intestinal Mucosa, Male, Middle Aged, Nerve Fibers, Neurons, Afferent, Pain Measurement, Abdominal Pain, Inflammation Mediators, Irritable Bowel Syndrome, TRPV Cation Channels
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