Is it true that coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa: Figure 1
Open accessAbstract
Prolyl-endopeptidase supplementation has been proposed to favour gliadin degradation as an alternative treatment for coeliac disease (CD), although the real usefulness of this therapy in vivo is still under discussion. 1 However, our data point to alternative treatments aiming to modify the intestinal microbiota in patients with CD by the use of probiotics and/or prebiotics. We propose that the induction of gliadin proteolysis in the human gut might not be the solution but the origin of CD.
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An increase in proteolytic activity towards gluten proteins has been observed in the duodenum and feces of celiac disease patients.
“an increase in proteolytic activity towards gluten proteins has been observed in the duodenum and feces of CeD patients.41,42”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [41]
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MEROPS: the peptidase database
Rawlings, N. D., Morton, F. R., Kok, C. Y., Kong, J., & Barrett, A. J. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm954 · Cited by 521 · see citing works
Imbalance in the composition of the duodenal microbiota of children with coeliac disease
Nadal, I., Donant, E., Ribes‐Koninckx, C., Calabuig, M., & Sanz, Y. (2007) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47410-0 · Cited by 396 · see citing works
Self-citationMitea, C., Havenaar, R., Drijfhout, J. W., et al. (2007) · Gut · doi:10.1136/gut.2006.111609 · Cited by 261 · see citing works
Presence of Bacteria and Innate Immunity of Intestinal Epithelium in Childhood Celiac Disease
Forsberg, G., Fahlgren, A., Hörstedt, P., Hammarström, S., Hernell, O., & Hammarström, M. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04157.x · Cited by 187 · see citing works
Tursi, A., Brandimarte, G., & Giorgetti, G. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07379.x · Cited by 187 · see citing works
Daum, S., Bauer, U., Foss, H., et al. (1999) · Gut · doi:10.1136/gut.44.1.17 · Cited by 140 · see citing works
Matrix metalloproteinase pattern in celiac duodenal mucosa
Ciccocioppo, R., Sabatino, A. D., Bauer, M. W., Riccia, D. N. D., Bizzini, F., Biagi, F., Cifone, M. G., Corazza, G. R., & Schuppan, D. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700225 · Cited by 103 · see citing works
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The emerging roles of bacterial proteases in intestinal diseases
Caminero, A., Guzman, M., Libertucci, J., & Lomax, A. E. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2181922 · Cited by 92 · see citing works
Caminero, A., Nistal, E., Herrán, A. R., Pérez-Andrés, J., Ferrero, M. A., Vaquero Ayala, L., Vivas, S., Ruiz de Morales, J. M. G., Albillos, S. M., & Casqueiro, F. J. (2015) · British Journal of Nutrition · doi:10.1017/s0007114515002767 · Cited by 70 · see citing works
Oleaga, C., Ciudad, C. J., Noé, V., & Izquierdo-Pulido, M. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/390385 · Cited by 25 · see citing works
- Authors
- Bernardo, D., Garrote, J. A., Nadal, I., León, A. J., Calvo, C., Fernández-Salazar, L., Blanco-Quirós, A., Sanz, Y., & Arranz, E.
- Affiliations
- Universidad de Valladolid (ES)
- Consejo Superior de Investigaciones Científicas (ES)
- Hospital Clínico Universitario de Valladolid (ES)
- Corresponding author
- Arranz, E
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2009-05-11
- Volume
- 58
- Issue
- 6
- Pages
- 886-887
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2069752121
- Cited by
- 98
- References
- 7
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 11 · 2020: 6 · 2019: 9 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 6 · 2014: 10 · 2013: 12 · 2012: 2
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- green
- uvadoc.uva.es
- Licence
- cc-by-nc-nd
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- University of Valladolid Documentary Repository (University of Valladolid) (acceptedVersion, cc-by-nc-nd)
- Hispana (acceptedVersion, cc-by-nc-nd)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- UVaDOC UVaDOC University of Valladolid Documentary Repository (University of Valladolid) (submittedVersion, cc-by-nc-nd)
- Funders
- Ministerio de Economía y Competitividad
- Generalitat Valenciana
- Universidad de Valladolid
- Topics
- Health Sciences › Medicine › Gastroenterology › Celiac Disease Research and Management
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Wheat and Barley Genetics and Pathology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- celiac disease, gliadin, prolyl endopeptidase, small intestinal mucosa, gut microbiota, probiotics, prebiotics
- MeSH terms
- Bacteria, Celiac Disease, Digestion, Duodenum, Electrophoresis, Polyacrylamide Gel, Gliadin, Humans, Intestinal Mucosa, Peptide Hydrolases, Case-Control Studies
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