The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes
Open accessAbstract
Objective: Invasive cancers arising from intraductal papillary mucinous neoplasm (IPMN) are recognised as a morphologically and biologically heterogeneous group of neoplasms. Less is known about the epithelial subtypes of the precursor IPMN from which these lesions arise. The authors investigate the clinicopathological characteristics and the impact on survival of both the invasive component and its background IPMN. Design and patients: The study cohort comprised 61 patients with invasive IPMN (study group) and 570 patients with pancreatic ductal adenocarcinoma (PDAC, control group) resected at a single institution. Multivariate analyses were performed using a stage-matched Cox proportional hazard model. Results: The histology of invasive components of the IPMN cohort was tubular in 38 (62%), colloid in 16 (26%), and oncocytic in seven (12%). Compared with PDAC, invasive IPMNs were associated with a lower incidence of adverse pathological features and improved mortality by multivariate analysis (HR 0.58; 95% CI 0.39 to 0.86). In subtype analysis, this favourable outcome remained only for colloid and oncocytic carcinomas, while tubular adenocarcinoma was associated with worse overall survival, not significantly different from that of PDAC (HR 0.85; 95% CI 0.53 to 1.36). Colloid and oncocytic carcinomas arose only from intestinal- and oncocytic-type IPMNs, respectively, and were mostly of the main-duct type, whereas tubular adenocarcinomas primarily originated in the gastric background, which was often associated with branch-duct IPMN. Overall survival of patients with invasive adenocarcinomas arising from gastric-type IPMN was significantly worse than that of patients with non-gastric-type IPMN (p=0.016). Conclusions: Tubular, colloid and oncocytic invasive IPMNs have varying prognosis, and arise from different epithelial subtypes. Colloid and oncocytic types have markedly improved biology, whereas the tubular type has a course that resembles PDAC. Analysis of these subtypes indicates that the background epithelium plays an equally, if not more, important role in defining the biology and prognosis of invasive IPMNs.
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Cites
Tanaka, M., Chari, S., Adsay, V., Carlos Castillo, F.-D., Falconi, M., Shimizu, M., Yamaguchi, K., Yamao, K., & Matsuno, S. (2006) · Pancreatology · doi:10.1159/000090023 · Cited by 2,044
Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2
Velcich, A., Yang, W., Heyer, J., Fragale, A., Nicholas, C., Viani, S., Kucherlapati, R., Lipkin, M., Yang, K., & Augenlicht, L. (2002) · Science · doi:10.1126/science.1069094 · Cited by 936
Intraductal Papillary Mucinous Neoplasms of the Pancreas: An Updated Experience
Sohn, T. A., Yeo, C. J., Cameron, J. L., Hruban, R. H., Fukushima, N., Campbell, K. A., & Lillemoe, K. D. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000128306.90650.aa · Cited by 874
Furukawa, T., Klöppel, G., Volkan Adsay, N., Albores-Saavedra, J., Fukushima, N., Horii, A., Hruban, R. H., Kato, Y., Klimstra, D. S., Longnecker, D. S., et al. (2005) · Virchows Archiv · doi:10.1007/s00428-005-0039-7 · Cited by 663
Chari, S. T., Yadav, D., Smyrk, T. C., DiMagno, E. P., Miller, L. J., Raimondo, M., Clain, J. E., Norton, I. A., Pearson, R. K., Petersen, B. T., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.36552 · Cited by 502
Adsay, N. V., Merati, K., Basturk, O., Iacobuzio-Donahue, C., Levi, E., Cheng, J. D., Sarkar, F. H., Hruban, R. H., & Klimstra, D. S. (2004) · The American Journal of Surgical Pathology · doi:10.1097/00000478-200407000-00001 · Cited by 463
Maitra, A., Adsay, N. V., Argani, P., Iacobuzio-Donahue, C., De Marzo, A., Cameron, J. L., Yeo, C. J., & Hruban, R. H. (2003) · Modern Pathology · doi:10.1097/01.mp.0000086072.56290.fb · Cited by 429
Pathology and genetics of tumors of the digestive system
Yajnik, V. (2001) · Gastroenterology · doi:10.1016/s0016-5085(01)70019-4 · Cited by 384
Hruban, R. H., Pitman, M. B., & Klimstra, D. S. (2007) · American Registry of PathologyWashington, DC eBooks · doi:10.55418/9781933477022 · Cited by 370
Self-citationD'Angelica, M., Brennan, M. F., Suriawinata, A. A., Klimstra, D., & Conlon, K. C. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000114132.47816.dd · Cited by 340
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International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas
Tanaka, M., Fernández-del Castillo, C., Adsay, V., Chari, S., Falconi, M., Jang, J.-Y., Kimura, W., Levy, P., Pitman, M. B., Schmidt, C. M., et al. (2012) · Pancreatology · doi:10.1016/j.pan.2012.04.004 · Cited by 2,354
Self-citationRevisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas
Tanaka, M., Fernández-del Castillo, C., Kamisawa, T., Jang, J. Y., Levy, P., Ohtsuka, T., Salvia, R., Shimizu, Y., Tada, M., & Wolfgang, C. L. (2017) · Pancreatology · doi:10.1016/j.pan.2017.07.007 · Cited by 1,797
Scheiman, J. M., Hwang, J. H., & Moayyedi, P. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.01.014 · Cited by 437
von Figura, G., Fukuda, A., Roy, N., Liku, M. E., Morris IV, J. P., Kim, G. E., Russ, H. A., Firpo, M. A., Mulvihill, S. J., Dawson, D. W., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2916 · Cited by 190
Patra, K. C., Kato, Y., Mizukami, Y., Widholz, S., Boukhali, M., Revenco, I., Grossman, E. A., Ji, F., Sadreyev, R. I., Liss, A. S., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0122-3 · Cited by 192
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Metadata
- Authors
- Mino-Kenudson, M., Fernández-del Castillo, C., Baba, Y., Valsangkar, N. P., Liss, A. S., Hsu, M., Correa-Gallego, C., Ingkakul, T., Perez Johnston, R., Turner, B. G., Androutsopoulos, V., Deshpande, V., McGrath, D., Sahani, D. V., Brugge, W. R., Ogino, S., Pitman, M. B., Warshaw, A. L., & Thayer, S. P.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2011-04-20
- Volume
- 60
- Issue
- 12
- Pages
- 1712-1720
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2146037272
- Cited by
- 293
- References
- 41
- FWCI
- 10.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Mino-Kenudson, M., Fernández-del Castillo, C., Baba, Y., Valsangkar, N. P., Liss, A. S., Hsu, M., Correa-Gallego, C., Ingkakul, T., Perez Johnston, R., Turner, B. G., Androutsopoulos, V., Deshpande, V., McGrath, D., Sahani, D. V., Brugge, W. R., Ogino, S., Pitman, M. B., Warshaw, A. L., & Thayer, S. P. (2011). Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes. Gut. https://doi.org/10.1136/gut.2010.232272
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