Bacteriuria and primary biliary cirrhosis.

Burroughs, A K; Rosenstein, I J; Epstein, O; Hamilton-Miller, J M; Brumfitt, W; Sherlock, S

doi:10.1136/gut.25.2.133

Cited by 214Liver Diseases and ImmunityUrinary Tract Infections ManagementUrinary Bladder and Prostate Research

Bacteriuria and primary biliary cirrhosis.

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Burroughs, A K, Rosenstein, I J, Epstein, O, Hamilton-Miller, J M, Brumfitt, W, Sherlock, S·1984·Gut

DOI 10.1136/gut.25.2.133PMC PMC1432247

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Abstract

Significant bacteriuria was found in 19% of 87 women with primary biliary cirrhosis, whereas in 89 women with other types of chronic liver disease bacteriuria was present in only 7%. In 74 women with rheumatoid arthritis 8% were bacteriuric. Midstream urine specimens obtained from 144 consecutive women with primary biliary cirrhosis attending hospital over a two year period showed that 50 (35%) developed bacteriuria during 12 months of follow up. Bacteriuria was unrelated to age, raised serum bilirubin, drug therapy or urinary pH but was more common in patients with late stage (fibrotic) disease as judged by histological criteria. Fifty seven per cent of bacteriuric primary biliary cirrhosis patients suffered more than one urinary infection. Fifty nine per cent of the 156 bacteriuric episodes were asymptomatic. The types of organism isolated, the antibiotic sensitivity patterns and cure rate were similar to those reported in bacteriuric women without other underlying disease. The reinfection rate (34%), however, was double that reported for bacteriuric episodes in 'problem' women with recurrent bacteriuria, indicating a special susceptibility to urinary infection. The most common isolates were E coli (70%), which did not show abnormal adhesiveness to uroepithelial or buccal cells of normal women, or to those of primary biliary cirrhosis patients. Patients with primary biliary cirrhosis have not been reported to be more susceptible to infection in general. Bacteriuria, however, was common throughout all clinical stages of primary biliary cirrhosis. Thus there may be a unique association between bacteriuria and primary biliary cirrhosis.

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Recurrent UTIs have been associated with PBC in several epidemiological studies.
“Recurrent UTIs have been associated with PBC in several epidemiological studies.62 114”
From The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines (2018) · cites this paper as [62]

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Authors: Burroughs, A. K., Rosenstein, I. J., Epstein, O., Hamilton-Miller, J. M., Brumfitt, W., & Sherlock, S.
ORCID: Burroughs, A K
Epstein, O
Venue: Gut
Publisher: BMJ
Published: 1984-02
Volume: 25
Issue: 2
Pages: 133-137
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.25.2.133
PMC: PMC1432247
OpenAlex: W2036233591
Cited by: 214
References: 23
Citations by year: 2025: 2 · 2024: 1 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 6 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 7 · 2013: 7 · 2012: 8
FWCI: 5.00
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Gut (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
Keywords: bacteriuria, primary biliary cirrhosis, urinary tract infection, Escherichia coli, asymptomatic bacteriuria, reinfection, fibrosis, chronic liver disease, women, infection susceptibility
MeSH terms: Adult, Aged, Arthritis, Rheumatoid, Bacteriuria, Escherichia coli, Female, Humans, Liver Cirrhosis, Biliary, Liver Diseases, Middle Aged

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Bacteriuria and primary biliary cirrhosis.

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