Relationship between disease activity indices and colonoscopic findings in patients with colonic inflammatory bowel disease.
Open accessAbstract
The Crohn's disease activity index, a similar index devised for patients with ulcerative colitis, and other commonly used laboratory indicators of disease activity have been studied in 50 patients with colonic inflammatory bowel disease undergoing routine colonoscopic assessment and compared with the histological extent and activity of disease. There was only poor correlation between the colonoscopic or histological findings and the indices of disease activity studied, showing that these are not reliable measures of disease activity or extent at the tissue level.
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An objective measure of inflammation is not necessarily reflective of a patient's symptoms.
“Similarly in ulcerative colitis, macroscopic changes at colonoscopy have correlated poorly with the PT clinical index, so an objective measure of inflammation is not necessarily reflective of a patient's symptoms 30 .”
From The Manitoba IBD Index: Evidence for a New and Simple Indicator of IBD Activity (2009) · cites this paper as [30]
In ulcerative colitis, macroscopic changes at colonoscopy have correlated poorly with the PT clinical index.
“Similarly in ulcerative colitis, macroscopic changes at colonoscopy have correlated poorly with the PT clinical index, so an objective measure of inflammation is not necessarily reflective of a patient's symptoms 30 .”
From The Manitoba IBD Index: Evidence for a New and Simple Indicator of IBD Activity (2009) · cites this paper as [30]
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- Authors
- Gomes, P., du Boulay, C., Smith, C. L., & Holdstock, G.
- Affiliations
- Southampton General Hospital (GB)
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1986-01
- Volume
- 27
- Issue
- 1
- Pages
- 92-95
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1433178
- OpenAlex
- W2091387052
- Cited by
- 339
- References
- 18
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 9 · 2018: 14 · 2017: 16 · 2016: 5 · 2015: 10 · 2014: 19 · 2013: 12 · 2012: 9
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- CDAI, ulcerative colitis, disease activity index, colonoscopy findings
- MeSH terms
- Blood Sedimentation, C-Reactive Protein, Colitis, Ulcerative, Colon, Colonoscopy, Crohn Disease, Humans, Leukocyte Count, Platelet Count, Serum Albumin
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