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Transit of pharmaceutical dosage forms through the small intestine.
Open accessAbstract
The gastrointestinal transit of pharmaceutical dosage forms has been measured in 201 studies in normal subjects using gamma scintigraphy. Solutions, small pellets, and single units (matrix tablets and osmotic pumps) were administered with different amounts of food in the stomach, ranging from fasted state to heavy breakfast. Gastric emptying was affected by the nature of the dosage form and the presence of food in the stomach. Solutions and pellets were emptied even when the stomach was in the digestive mode, while single units were retained for long periods of time, depending on the size of the meal. In contrast, measured intestinal transit times were independent of the dosage form and fed state. The small intestinal transit time of about three hours (mean +/- 1 h SEM) has implications for the design of dosage forms for the sustained release of drugs in specific positions in the gastrointestinal tract.
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Citations
Cited by
Amidon, G. L., Lennernäs, H., Shah, V. P., & Crison, J. R. (1995) · Pharmaceutical Research · doi:10.1023/a:1016212804288 · Cited by 5,430
Dissolution Testing as a Prognostic Tool for Oral Drug Absorption: Immediate Release Dosage Forms
Dressman, J. B., Amidon, G. L., Reppas, C., & Shah, V. P. (1998) · Pharmaceutical Research · doi:10.1023/a:1011984216775 · Cited by 1,097
Charman, W. N., Porter, C. J. H., Mithani, S., & Dressman, J. B. (1997) · Journal of Pharmaceutical Sciences · doi:10.1021/js960085v · Cited by 617
Formulation, stabilisation and encapsulation of bacteriophage for phage therapy
Malik, D. J., Sokolov, I. J., Vinner, G. K., Mancuso, F., Cinquerrui, S., Vladisavljevic, G. T., Clokie, M. R. J., Garton, N. J., Stapley, A. G. F., & Kirpichnikova, A. (2017) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2017.05.014 · Cited by 594
Population-Based Mechanistic Prediction of Oral Drug Absorption
Jamei, M., Turner, D., Yang, J., Neuhoff, S., Polak, S., Rostami-Hodjegan, A., & Tucker, G. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9099-y · Cited by 452
Metadata
- Authors
- Davis, S. S., Hardy, J. G., & Fara, J. W.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1986-08
- Volume
- 27
- Issue
- 8
- Pages
- 886-892
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2085444179
- Cited by
- 853
- References
- 0
- FWCI
- 21.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Davis, S. S., Hardy, J. G., & Fara, J. W. (1986). Transit of pharmaceutical dosage forms through the small intestine. Gut. https://doi.org/10.1136/gut.27.8.886
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
