The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Measurement of gastrointestinal pH profiles in normal ambulant human subjects
Open accessAbstract
Gastrointestinal (GI) pH has been measured in 66 normal subjects using a pH sensitive radiotelemetry capsule passing freely through the gastrointestinal tract. Signals were recorded with a portable solid state receiver and recording system, enabling unconstrained measurements with normal ambulatory activities for up to 48 h during normal GI transit. Capsule position in the gut was monitored by surface location using a directional detector. Gastric pH was highly acidic (range 1.0-2.5) in all subjects. The mean pH in the proximal small intestine was 6.6 (0.5) for the first hour of intestinal recording. By comparison the mean pH in the terminal ileum was 7.5 (0.4) (p less than 0.001). In all subjects there was a sharp fall in pH to a mean of 6.4 (0.4) (p less than 0.001) as the capsule passed into the caecum. Values are means (SD). pH then rose progressively from the right to the left colon with a final mean value of 7.0 (0.7) (p less than 0.001).
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“This suggests that aNFC/AP cryogels can generally protect acid-sensitive drugs in the gastric environment while achieving rapid release in the healthy small intestine, typically at a pH of 6.5–7.5 [52].”
From Amidated Pectin/Nanocellulose Hybrid Cryogel System with a pH-Responsive Release Profile for Small Intestinal Delivery (2025) · cites this paper as [52]
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Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers
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Ferretti, P., Pasolli, E., Tett, A., Asnicar, F., Gorfer, V., Fedi, S., Armanini, F., Truong, D. T., Manara, S., Zolfo, M., et al. (2018) · Cell Host & Microbe · doi:10.1016/j.chom.2018.06.005 · Cited by 1,292
Coeliac disease: dissecting a complex inflammatory disorder
Sollid, L. M. (2002) · Nature reviews. Immunology · doi:10.1038/nri885 · Cited by 967
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Metadata
- Authors
- Evans, D. F., Pye, G., Bramley, R., Clark, A. G., Dyson, T. J., & Hardcastle, J. D.
- Affiliations
- Queen's Medical Centre (GB)
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1988-08
- Volume
- 29
- Issue
- 8
- Pages
- 1035-1041
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1433896
- OpenAlex
- W2089407496
- Cited by
- 1,240
- References
- 23
- Citations by year
- 2026: 38 · 2025: 74 · 2024: 52 · 2023: 67 · 2022: 70 · 2021: 84 · 2020: 67 · 2019: 58 · 2018: 47 · 2017: 55 · 2016: 49 · 2015: 59 · 2014: 67 · 2013: 43 · 2012: 56
- FWCI
- 7.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical Chemistry and Sensors
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Keywords
- gastrointestinal pH, gastric pH, terminal ileum, cecum, colon, ambulatory pH monitoring, gastrointestinal transit, normal subjects
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Gastrointestinal Contents, Humans, Hydrogen-Ion Concentration, Male, Middle Aged, Reference Values
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