The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Role of interleukin 1 in inflammatory bowel disease--enhanced production during active disease.
Open accessAbstract
Interleukin 1 is a polypeptide cytokine produced by various cell types and has been shown to have a major role in inflammatory and immunological responses. In experimental colitis it proved to be a dominant mediator and a reliable marker of inflammation. The aim of the present study was to determine in vitro the extent of production and release of interleukin 1 from colonic mucosa of patients with active untreated inflammatory bowel disease. Colonic mucosal biopsy specimens were obtained during colonoscopy from 17 patients with ulcerative colitis, eight patients with Crohn's disease of the colon, and 16 normal control subjects. Interleukin 1 content was determined in fresh and 24 hour organ cultured mucosa as well as in cultured medium. Interleukin 1 content and release were significantly higher in the inflamed mucosa compared with that of control subjects. Prednisolone inhibited interleukin 1 release in a dose dependent fashion. We conclude that colonic mucosal interleukin 1 content and production is significantly raised in active inflammatory bowel disease and may have a role in the pathogenesis of the inflammatory response. Pharmacological suppression of tissue interleukin 1 production may have a beneficial therapeutic effect.
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Cites
There is more than one interleukin 1
Oppenheim, J. J., Kovacs, E. J., Matsushima, K., & Durum, S. K. (1986) · Immunology Today · doi:10.1016/0167-5699(86)90124-6 · Cited by 1,203
Corticosteroids inhibit murine macrophage Ia expression and interleukin 1 production.
Snyder, D. S., & Unanue, E. R. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.129.5.1803 · Cited by 649
Interleukin 1: An Immunological Perspective
Durum, S. (1985) · Annual Review of Immunology · doi:10.1146/annurev.immunol.3.1.263 · Cited by 580
Sharon, P., Ligumsky, M., Rachmilewitz, D., & Zor, U. (1978) · PubMed · Cited by 451
Self-citationMahida, Y. R., Wu, K., & Jewell, D. P. (1989) · Gut · doi:10.1136/gut.30.6.835 · Cited by 427
Role of Prostaglandins in Ulcerative Colitis
Sharon, P., Ligumsky, M., Rachmilewitz, D., & Zor, U. (1978) · Gastroenterology · doi:10.1016/s0016-5085(19)31672-5 · Cited by 388
Self-citationInflammatory mediators of experimental colitis in rats
Rachmilewitz, D., Simon, P. L., Schwartz, L. W., Griswold, D. E., Fondacaro, J. D., & Wasserman, M. A. (1989) · Gastroenterology · doi:10.1016/0016-5085(89)90068-1 · Cited by 249
Self-citationInterleukin 1 in Crohn's disease.
Satsangi, J., Wolstencroft, R. A., Cason, J., Ainley, C. C., Dumonde, D. C., & Thompson, R. P. H. (1987) · PubMed Central · Cited by 122
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Intestinal immunity and inflammation: Recent progress
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Cited by
Bone, R. C. (1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-6-457 · Cited by 1,368
Cytokine regulation of tight junctions
Capaldo, C. T., & Nusrat, A. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.08.027 · Cited by 718
IL-1β Causes an Increase in Intestinal Epithelial Tight Junction Permeability
Al-Sadi, R. M., & Ma, T. Y. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.7.4641 · Cited by 601
Coccia, M., Harrison, O. J., Schiering, C., Asquith, M. J., Becher, B., Powrie, F., & Maloy, K. J. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20111453 · Cited by 580
Melgar, S., Karlsson, A., & Michaëlsson, E. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00467.2004 · Cited by 578
Metadata
- Authors
- Ligumsky, M., Simon, P. L., Karmeli, F., & Rachmilewitz, D.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1990-06
- Volume
- 31
- Issue
- 6
- Pages
- 686-689
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2011199158
- Cited by
- 400
- References
- 11
- FWCI
- 14.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ligumsky, M., Simon, P. L., Karmeli, F., & Rachmilewitz, D. (1990). Role of interleukin 1 in inflammatory bowel disease--enhanced production during active disease. Gut. https://doi.org/10.1136/gut.31.6.686
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
