Effects of omeprazole on neutrophil chemotaxis, super oxide production, degranulation, and translocation of cytochrome b-245.
Open accessAbstract
The effects of omeprazole on polymorphonuclear neutrophil (PMN) chemotaxis, superoxide generation, degranulation and translocation of cytochrome b-245 were investigated. Omeprazole (10(-6) - 5 x 10(-3) mol/l) reduced chemotaxis under agarose in a dose dependent manner, and the effect was irreversible. Superoxide anion generation was inhibited 50% at a concentration of 2.5 x 10(-5) mol/l and completely abolished at 5 x 10(-3) mol/l. Acid degraded omeprazole also inhibited O2- generation. Omeprazole did not scavenge O2- generated in a cell free xanthin-xanthine oxidase system. Degranulation by PMNs was inhibited only by omeprazole in concentrations above 10(-4) mol/l. Translocation of cytochrome b-245, essential for generation of O2-, was not affected by omeprazole. In conclusion, the anti-ulcer agent omeprazole in concentrations obtained during intravenous administration may inhibit the function of PMNs in vitro.
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PPIs have unfavorable effects on gastric functions and host defensive mechanisms, causing delayed gastric emptying, decreased gastric mucus viscosity, increased bacterial load and increased bacterial translocation.
“PPIs have unfavorable effects on gastric functions and host defensive mechanisms, causing delayed gastric emptying, decreased gastric mucus viscosity, increased bacterial load and increased bacterial translocation[55-57].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [57]
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- Authors
- Wandall, J. H.
- Affiliations
- Massachusetts General Hospital (US)
- Corresponding author
- Wandall, J H
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1992-05-01
- Volume
- 33
- Issue
- 5
- Pages
- 617-621
- ISSN
- 0017-5749 (ISSN-L)
- PMC
- PMC1379289
- OpenAlex
- W2148583557
- Cited by
- 179
- References
- 27
- Citations by year
- 2024: 7 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 5 · 2015: 7 · 2014: 6 · 2013: 9 · 2012: 9
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
- Keywords
- omeprazole, neutrophil chemotaxis, superoxide production, neutrophil degranulation, H2 receptor antagonists, antiulcer drugs, drug immunotoxicity
- MeSH terms
- Chemotaxis, Leukocyte, Cytochrome b Group, Dose-Response Relationship, Drug, Humans, Neutrophils, Omeprazole, Superoxides, Cell Degranulation, In Vitro Techniques
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